南京林业大学化学工程学院黄超伯

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姓名：        黄超伯        系别：        林产化工系
职务：        副院长        职称：        教授 博士生导师
最终学历：                最终学位：        博士
办公电话：                电子邮箱：        Chaobo.HUANG@njfu.edu.cn
　个人简介：
课题组主页：bfm.njfu.edu.cn
黄超伯，药学博士，南京林业大学林产化工系教授，博士生导师，入选第四批江苏省特聘教授，校“杰出青年学者培养计划”入选者，中国林学会青年工作委员会委员。2003年江西师范大学获理学学士学位，2006年江西师范大学获理学硕士学位（导师：侯豪情教授），2011年比利时根特大学（Ghent University, Belgium）获药学博士学位 （导师：Stefaan De Smedt教授, 比利时皇家医学科学院院士和Journal of Controlled Release 欧洲主编），并获得2010年国家优秀自费留学生奖学金，2011-2013年在瑞士联邦理工（洛桑）（EPFL, Switzerland）从事博士后研究工作（合作导师：Martin Gijs教授）。目前主要从事生物基功能型复合材料的制备及其应用研究工作。在Chemical Society Reviews, Advanced Materials, Advanced Functional Materials, Journal of Controlled Release, Biomaterials等期刊发表SCI论文30余篇，被他人引用800余次，单篇最高被引用220余次，1篇文章入选全球Top 1% ESI高被引论文。并于2015年和2018年出版英文专著2部，已申请发明专利23件（已授权2件）。英国科普杂志《New Scientist》、比利时报纸《the latest news》、荷兰杂志《C2W medicine》和《Materials views》等相继撰文报道介绍了相关科研成果。
　主要从事：
1.   新型4D聚合物材料
2.   食品\药品防伪材料
3.   绿色过滤\分离材料
4.   刺激响应（智能）型药物传输和释放材料
5.   林源活性物质功效评价
　主持或参与课题：
1.国家自然科学基金(21774060), 2018.01-2021.12, 项目负责人
2.国家重点研发计划专项子课题（2017YFF0207800），2017.7-2019.12，项目负责人
3.西安交通大学金属材料强度国家重点实验室开放基金（20171914），2017.6-2019.5，项目负责人
4.江苏省生物质能源与材料重点实验室开放基金重点项目（JSBEM2016011），2017-2018，项目负责人
5.国家自然科学基金(21644004),2017.1-2017.12, 项目负责人
6.江苏省高校自然科学研究重大项目（16KJA220006）,2017-2019，项目负责人
7.教育部留学回国人员科研启动基金,2015-2017，项目负责人
8.江苏省生物质绿色燃料与化学品重点实验室开放基金重点项目(JSBGFC14001), 2015-2017，项目负责人
9.江苏省特聘教授科研启动， 2014-2016，项目负责人
　获奖情况：
1. 国家优秀自费留学生奖学金获得者，2010
　发表论文：
2018
38. Wanlin Fu，Yunqian Dai*， Jilan Tian， Chaobo Huang， Zhongche Liu， Ken Liu， Linzhi Yin， Fangfang Huang， Yingwei Lu and Yueming Sun*. In situ growth of hierarchical Al2O3 nanostructures onto TiO2 nanofibers surface: super-hydrophilicity, efficient oil/water separation and dye-removal, Nanotechnology, 2018, 29, 345607-345619
37. Fang Wang*, Jian Yuan, Qian Zhang, Siqian Yang, Shaohua Jiang, Chaobo Huang. PTX-loaded three-layer PLGA/CS/ALG nanoparticle based on layer-by-layer method for cancer therapy, Journal of Biomaterials Science, Polymer Edition, 2018, DOI: 10.1080/09205063.2018.1475941
36. Shan Ye, Lei Jiang, Jimin Wu, Chen Su, Chaobo Huang, Xiufeng Liu*, Wei Shao*. Flexible Amoxicillin-Grafted Bacterial Cellulose Sponges for Wound Dressing: In Vitro and in Vivo Evaluation, ACS Applied Materials & Interfaces, 2018, 10, 5862−5870
35. Miaomiao Zhu, Dawei Hua, Ming Zhong, Lingfeng Zhang, Fang Wang, Buhong Gao, Ranhua Xiong, Chaobo Huang*. Antibacterial and Effective Air Filtration Membranes by “Green” Electrospinning and Citric Acid Crosslinking, Colloid and Interface Science Communications, 2018(23),52-58
34. Xiansong Shi#, Zhi Xu#, Chaobo Huang, Yong Wang*, Zhanfeng Cui. Selective Swelling of Electrospun Block Copolymers: From Perforated Nanofibers to High Flux and Responsive Ultrafiltration Membranes, Macromolecules, 2018, 51,6,2283-2292.
33. Shaohua Jiang*, Donghua Han, Chaobo Huang, Gaigai Duan, Haoqing Hou*. Temperature-induced Molecular Orientation and Mechanical Properties of Single Electrospun Polyimide Nanofiber, Materials Letters, 2018, 216, 81-83.
32. Miaomiao Zhu, Dawei Hua, Hui Pan, Fei Wang, Bella Manshian, Stefaan J. Soenen, Ranhua Xiong*, Chaobo Huang*. Green electrospun and crosslinked poly(vinyl alcohol)/poly(acrylic acid) composite membranes for antibacterial effective air filtration. Journal of Colloid and Interface Science, 2018, 511, 411-423.
31. Zhicheng Jiang, Heyang Zhang, Miaomiao Zhu, Dan Lv, Jianfeng Yao, Ranhua Xiong*,Chaobo Huang*. Electrospun soy-protein-based nanofibrous membranes for effective antimicrobial air filtration, Journal of Applied Polymer Science, 2018, 135(8), 45766-45773.
2017
30. Xiongfei Zhang#, Yi Feng#, Chaobo Huang, Yichang Pan, Jianfeng Yao *. Temperature-induced formation of cellulose nanofiber film with remarkably high gas separation performance, Cellulose, 2017, 24(12), 5649-5656.
29. Buhong Gao, Fengyi Zhao, Yingchun Miao, Huihua Min, Li Xu *, Chaobo Huang*. Boron- and nitrogen-doped photoluminescent polymer carbon nanoparticles as nanosensors for imaging detection of Cu2+ and biothiols in living cells. RSC Adv., 2017, 7, 47654–47661.
28. Jingquan Han#, Yiying Yue#, Qinglin Wu, Chaobo Huang, Hui Pan, Xianxu Zhan, Changtong Mei*, Xinwu Xu*. Effects of nanocellulose on the structure and properties of poly(vinyl alcohol)-borax hybrid foams[J]. Cellulose, 2017, 24(10), 4433-4448.
27. Ping-Ping Xin, Yao-Bing Huang, Chung-Yun Hse, Huai N. Cheng, Chaobo Huang, Hui Pan*. Modification of Cellulose with  Succinic Anhydride in TBAA/DMSO Mixed Solvent under Catalyst-Free Conditions. Materials, 2017, 10(5), 526-538.
26. Wen Gu*, Ting-Ting Miao, Da-Wei Hua, Xiao-Yan Jin, Xu-Bing Tao, Chaobo Huang, Shi-Fa Wang. Synthesis and in vitro cytotoxic evaluation of new 1H-benzo [d] imidazole derivatives of dehydroabietic acid. Bioorganic & Medicinal Chemistry Letters, 2017, 27(5), 1296-1300.
25. Wenjing Ma#, Sangram Keshari Samal#, Zhongche Liu, Ranhua Xiong, Stefaan C. De Smedt, Bharat Bhushan, Qilu Zhang* and Chaobo Huang*. Dual pH- and ammonia-vapor-responsive electrospun nanofibrous membranes for oil–water separations, Journal of Membrane Science, 2017, 537, 128–139.
24. Zhongfu Guo#, Guosheng Tang#, Yonghong Zhou, Liu Shuwu, Haoqing Hou, Zhenyu Chen, Jinhui Chen, Chunhong Hu, Fei Wang, Stefaan C. De Smedt, Ranhua Xiong*, and Chaobo Huang*. ‘Fabrication of Sustained-Release CA-PU Coaxial Electrospun Fiber Membranes for Plant Grafting Application, Carbohydrate Polymers, 2017, 169, 198-205.
23. Miaomiao Zhu#, Jingquan Han#, Fang Wang, Wei Shao, Ranhua Xiong, Qilu Zhang, Hui Pan, Yong Yang, Sangram Keshari Samal, Feng Zhang*, Chaobo Huang*. Electrospun Nanofibers Membranes for Effective Air Filtration, Macromolecular Materials and Engineering, 2017, 302(1), 1600353-1600380.
22. Wenjing Ma, Zhongfu Guo, Juntao Zhao, Qian Yu, Fang Wang, Jingquan Han, Hui Pan, Jianfeng Yao，Qilu Zhang，Sangram Keshari Samal, Stefaan De Smedt* and Chaobo Huang*. Polyimide/Cellulose Acetate Core/Shell Electrospun Fibrous Membranes for Oil-water Separation, Separation and Purification Technology, 2017, 177, 71-85.
21. Yi Feng, Haiqiang Lu, Xiaoli Gu, Jianhao Qiu, Mingmin Jia, Chaobo Huang, Jianfeng Yao*. ZIF-8 derived porous N-doped ZnO with enhanced visible light-driven photocatalytic activity, Journal of Physics and Chemistry of Solids, 2017, 102, 110–114
2016
20. Wenjing Ma#, Qilu Zhang#, Dawei Hua#, Ranhua Xiong, Juntao Zhao, Weidong Rao, shenlin Huang, Xianxu Zhan, Fei Chen, Chaobo Huang*. Electrospun Fibers for Oil-Water Separation, RSC Advances，2016, 6, 12868-12884
19. Shao Wei*, Wang Shuxia, Liu Hui, Wu Jimin, Huang Min, Ma Wenjing, Huang Chaobo.Rheological and Mechanical Study of Regenerated Cellulose/Multi-walled Carbon Nanotubes Composites, Nanotechnology, 2016, 27, 395707-395715
18. Dawei Hua, Zhongche Liu, Fang Wang, Buhong Gao, Fei Chen, Qilu Zhang, Ranhua Xiong, Jingquan Han, Sangram Keshari Sama*, Stefaan C. De Smedt*, Chaobo Huang*, pH Responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for  intravaginal drug delivery, Carbohydrate Polymers, 2016, 151  1240–1244
17. Wenjing Ma#, Qilu Zhang#, Sangram Keshari Sama#, Fang Wang, Buhong Gao, Hui Pan, Haijun Xu, Jianfeng Yao, Xianxu Zhan, Stefaan C. De Smedt*, Chaobo Huang*. Core-sheath structured electrospun nanofibrous membranes for oil–water separation, RSC Advances，2016, 6, 41861-41870
16. Fang Wang*, Siqian Yang, Jian Yuan,Qinwei Gao and Chaobo Huang*. Effective method of chitosan-coated alginate nanoparticles for target drug delivery applications, Journal of Biomaterials Applications, 2016, 31, 3-12
15. Yaobing Huang#, Pingping Xin#, Jiaxin Li, Yueying Shao, Chaobo Huang, and Hui Pan*. Room-Temperature Dissolution and Mechanistic Investigation of Cellulose in a Tetra-Butylammonium Acetate/Dimethyl Sulfoxide System, ACS Sustainable Chemistry & Engineering, 2016, 4, 2286–2294.
2015
14. Wang Fang*, Yang Siqian, Hua Dawei, Yuan Jian, Huang Chaobo* & Gao Qinwei. A novel preparation method of Paclitaxcel loaded Folate-modified Chitosan Microparticles and in vitro Evaluation，Journal of Biomaterials Science, Polymer Edition, 2015, 27(3), 276-289
13. Buhong Gao, Ying Tang, Haijun Sun, Yan Xuan, Li Xu* and Chaobo Huang*. A label-free and turn-on fluorescence sensor for sensitive and selective detection of iodide using carbon nanodots/silver nanocomposites， Analytical Methods , 2015, 7, 4038-4043.
2014
12. Chaobo. Huang#, Q. Ramadan#, J. B. Wacker, H. C. Tekin, C. Ruffert, G. Verg`eres, P. Silacci and M. A. M. Gijs*. Microfluidic chip for monitoring Ca2+ transport through a confluent layer of intestinal cells. RSC Advances, 2014, 4 (95), 52887-52891.
11. Chaobo Huang#, S. J. Soenen#, E. van Gulck, J. Rejman, B. Geers, B. Lucas, G. Vanham, V. Shahin, P. Spanoghe, J. Demeester, S. C. De Smedt*. Electrospun polystyrene fibers for HIV entrapment. Polymers for Advanced Technologies, 2014, 25(8), 827-834.
独立建组前
10. Q. Ramadan, H. Jafarpoorchekab, Chaobo Huang, P. Silacci, S. Carrara, G. Koklü, J. Ghaye, J. Ramsden, C. Ruffert, G. Vergères, M. Gijs, NutriChip: nutrition analysis meets microfluidics, Lab on a chip, 2013, 13, 196-203.
9. T. Saggese, A. A. Young, Chaobo Huang, K. Braeckmans, S. C. De Smedt, S. Read McGlashan, Development of a method for the measurement of primary cilia length in 3D,  Cilia ,2012, 1:11.
8. Chaobo Huang#, S. J. Soenen#, J. Rejman, J. Trekker, C. Liu, L. Lagae, W. Ceelen, C. Wilhelm, J. Demeester, S. C. De Smedt, Magnetic Electrospun Fibers for Cancer Therapy, Advanced Functional Materials, 2012，22, 2479.
7. Chaobo Huang#, S. J. Soenen#, E. van Gulck, G. Vanham, J. Rejman, S. Van Calenbergh, C. Vervaet, T. Coenye, H. Verstraelen, M. Temmerman, J. Demeester, S. C. De Smedt, Electrospun cellulose acetate phthalate fibers for semen induced anti-HIV vaginal drug delivery, Biomaterials, 2012, 33, 962.
6. Chaobo Huang#, S. J. Soenen#, J. Rejman, B. Lucas, K. Braeckmans, J. Demeester, Stefaan C De Smedt*. Stimuli-responsive electrospun fibers and their applications, Chemical Society Reviews, 2011, 40(5), 2417-2434.
5. Chaobo Huang, Lucas, C. Vervaet, K. Braeckmans, S. Van Calenbergh, I. Karalic, M. Vandewoestyne, D. Deforce, J. Demeester, Stefaan C De Smedt *. Unbreakable Codes in Electrospun Fibers: Digitally Encoded Polymers to Stop Medicine Counterfeiting, Advanced Materials, 2010, 22(24), 2657-2662.
4. Chaobo Huang，Bart Lucas，Chris Vervaet，Kevin Braeckmans，Serge Van Calenbergh，Izet Karalic，M. Vandewoestyne，Dieter Deforce，Jo Demeester，Stefaan C. De Smedt*. Unbreakable codes in electrospun fibers to stop medicine counterfeiting，Journal of Controlled Release, 2010, 148(1), e13-e15.
3. Chaobo Huang, S. L. Chen, C. L. Lai, D. H. Reneker, H. Qiu, Y. Ye, H. Q. Hou*. Electrospun polymer nanofibres with small diameters, Nanotechnology, 2006, 17 (6), 1558-1563.
2. Chaobo Huang, S. Q. Wang, H. Zhang, T. T. Li, S. L. Chen, C. L. Lai, H. Q. Hou*. High strength electrospun polymer nanofibers made from BPDA-PDA polyimide, European Polymer Journal, 2006, 42 (5), 1099-1104.
1. Chaobo Huang, S. L. Chen, D. H. Reneker*, C. L. Lai, H. Q. Hou*. High-strength mats from electrospun poly(p-phenylene biphenyltetracarboximide) nanofibers, Advanced Materials, 2006, 18(5), 668-671.
　发明专利：
1. 黄超伯，华大威，马文静，郭中富，王芳，高步红，一种PU/CAP芯鞘结构纤维的制备方法，专利号：ZL201510259065.2 （2017年授权）
2. 黄超伯，马文静，刘中车，郭中富，华大威，陈颖琛，纳米纤维膜的制备方法，专利号：ZL 2015 1 0332247.8 (2017年授权)

biyan

 南京林业大学黄超伯教授团队以生物基生物全降解材料葡甘露聚糖为基底，复合水溶性可生物降解高分子材料聚乙烯醇，以柠檬酸为热交联剂，随后在复合纤维上负载可见光响应金属氧化物纳米氧化锌。整个制备过程都是以水为溶剂，不添加任何有机溶剂，制备的纤维膜绿色环保可生物降解。所得高孔隙率基体具有良好的三维联通孔道结构，透气性好，负载的纳米颗粒有效增加了基体材料的比表面积；纳米纤维和纳米颗粒组成的拦截网络显著提高了纤维材料的过滤性能，对空气中的超细颗粒（直径300nm左右）的过滤效率高于99.99%，几乎不影响膜孔道阻力。此复合纤维对革兰氏阴性菌和革兰氏阳性菌都具有良好的抑制效果，能够实现空气污染物过滤功能的同时对细菌具有良好的防治效果。此外，该复合纤维膜还具有光催化降解有机染料的功能，降解效率高达98%。可生物降解聚合物与活性金属纳米颗粒的结合形成了良好的催化体系，对空气污染、水处理等环境治理领域具有广阔的前景。

  此项工作发表于ACS Applied Materials Interfaces期刊，论文第一作者为南京林业大学硕士生吕丹，比利时根特大学熊燃华博士和南京林业大学黄超伯教授为论文的通讯作者，南京林业大学为第一完成单位。

  近年来，黄超伯教授团队基于生物基绿色多功能纳米纤维过滤膜进行了较为系统且深入的研究，相关文章发表在Carbohydrate Polymers

(https://doi.org/10.1016/j.carbpol.2018.09.075)，Journal of Colloid and Interface Science (https://doi.org/10.1016/j.jcis.2017.09.101)，

Colloid and Interface Science Communications (https://doi.org/10.1016/j.colcom.2018.01.002)等杂志。

  相关链接：https://pubs.acs.org.ccindex.cn/doi/10.1021/acsami.9b01508

  实验室课题组主页：http://bfm.njfu.edu.cn/

gmao800

近日，化学工程学院2020级硕士生张小丽和2018级博士生曲清莉在国际期刊Advances in Colloid and Interface Science（影响因子12.9），在线发表了题为"Core-shell Microparticles: From Rational Engineering to Diverse Applications"的综述论文（DOI: 10.1016/j.cis.2021.102568）。通讯作者为我校黄超伯教授、华大威博士和比利时鲁汶大学Stefaan J. Soenen教授。
        由两种或两种以上不同化学成分组成的微米级芯壳聚合物微粒子，在生物医学应用中，其物理和化学性能往往比单一成分的同类粒子更好。在过去的几十年里，人们在可降解的芯壳微球的制备上做出了巨大的努力，使其具有特定的结构和复合性能。芯壳微球具有一些独特优势: (1)壳能够封装和包装活性分子，如活性药物成分和细胞，从而保护此类物质免受外界的化学和物理变化。（2）壳可提供不同的表面官能团，允许粒子表面进一步的化学修饰和生物偶联。（3）利用先进的材料可以生成具有半透膜性质的壳，使其能够与外界环境进行物质交换和信息传递。
        该工作综述了近些年芯壳微球的先进设计方法，如自组装，微流体，同轴电喷法和气辅法。此外，各种芯壳微球在生物医学领域的应用前景，包括人工细胞、给药、细胞培养和生物传感（图1）。该文还总结了现阶段芯壳微球合理设计的一些挑战：（1）通过将各种合成步骤组装到一个装置中，可以很容易地一步制备出结构复杂的芯壳微球，但大规模生产仍是一个值得探讨的问题。（2）生物医学的进步为改进载体载荷的使用提供了新的方法。然而，用于装载活性材料的材料太少，因此寻找合适的材料制备芯壳微球的需求尚未得到满足。（3）设计不同的芯壳结构，实现不同的功能。例如，在多室芯壳微球中，可以通过级联反应来实现多种酶在某些细胞器或器官中的协同效应。相反，在相同条件下，控制两种不同药物的释放动力学仍然是一个难题。此外，提出了生物相容性芯壳微球的未来发展方向，并提出了以下研究目标:(1)改进现有制备策略，实现芯壳微球的规模化和通用性。(2)促进实验室研究向实际应用的转变。随着人工细胞、药物递送、细胞培养和生物传感技术的发展，芯壳微球将成为现代医学发展的重要工具之一。

图1. 芯壳微球的制备及其应用。

        全文链接：https://doi.org/10.1016/j.cis.2021.102568