武汉大学高等研究院孔望清

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孔望清，武汉大学高等研究院教授，博士生导师。2006年至2011年在浙江大学攻读博士学位，导师是中国科学院院士麻生明教授。2011年至2014年加入瑞士苏黎世大学（UZH），从事博士后研究工作，合作导师是Cristina Nevado。2014年至2017年在瑞士洛桑联邦理工大学（EPFL），从事博士后研究工作，合作导师是Jieping Zhu。他获得的主要奖项包括：宝钢优秀学生奖（2009），浙江省优秀毕业生（2011），苏黎世大学博士后基金（2011），诺华制药博士后奖学金（2012）。2017年加入武汉大学高等研究院，开展独立科学研究工作。

孔望清
教授，博士生导师
邮箱：wqkong@whu.edu.cn
课题组主页：http://wqkong.whu.edu.cn


研究方向
1）金属有机化学：过渡金属不对称催化
2）自由基化学：发展新的策略实现自由基反应的立体选择性控制
3）开展具有生物活性天然产物和药物分子的高效合成研究


教育与研究经历
2017.04-至今 武汉大学高等研究院，教授
2014.10-2017.03   瑞士洛桑联邦理工大学 (EPFL)，博士后，导师： Jieping Zhu
2011.09-2014.09   瑞士苏黎世大学 (UZH)，博士后，导师： Cristina Nevado
2006.09-2011.06   浙江大学，博士，导师：麻生明教授（中国科学院院士）


荣誉与奖励
诺华制药博士后奖学金（2012）
苏黎世大学博士后基金（2011）
浙江省优秀毕业生（2011）
宝钢优秀学生奖（2009）


Publications
22. Kuai Wang, Zhengtian Ding, Zhijun Zhou, and Wangqing Kong*. Ni-Catalyzed Enantioselective Reductive Diarylation of Activated Alkenes by Domino Cyclization/Cross-Coupling. J. Am. Chem. Soc., 2018, 140, 12364-12368.
21. Yuanyuan Ping, Yuxiu Li, Jieping Zhu*, Wangqing Kong*. Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201806088.
20. Yuxiu Li, Kuai Wang, Yuanyuan Ping, Yifan Wang, and Wangqing Kong*. Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles. Org. Lett. 2018, 20, 921−924 (Highlighted by Synfacts, 2018, 14(4), 410)
19. Kuai Wang, Wangqing Kong*. Recent Advances in Transition Metal Catalyzed Asymmetric Radical Reactions. Chin. J. Chem. 2018, 36, 247-256. (Cover Story)
Before independent work:
18. Wangqing Kong, Qian Wang, Jieping Zhu*. Water as hydride source in palladium-catalyzed enantioselective reductive Heck reaction. Angew. Chem. Int. Ed. 2017, 56, 3987-3991. (Chosen by the Editors as a “Hot Paper”) (Highlighted by Synfacts, 2017, 13(5), 495) (Highly Cited Paper)
17. Wangqing Kong, Qian Wang, Jieping Zhu*. Switchable synthesis of diversely functionalized oxindoles enabled by migratory insertion of isocyanide to a transient σ-alkylpalladium(II) complex. Angew. Chem. Int. Ed. 2016, 55, 9714-9718.
16. Wangqing Kong, Qian Wang, Jieping Zhu*. Palladium-catalyzed enantioselective domino heck/intermolecular C-H bond functionalization: Development and application to the synthesis of (+)-esermethole. J. Am. Chem. Soc. 2015, 137, 16028-16031. (Highlighted by Synfacts, 2016, 12(3), 274.)
15. Wangqing Kong, Noelia Fuentes, Andres García-Domínguez, Estíbaliz Merino, Cristina Nevado*. Stereoselective synthesis of highly functionalized indanes and dibenzocycloheptadienes via complex radical cascades. Angew. Chem. Int. Ed. 2015, 54, 2487-2491.
14. Noelia Fuentes, Wangqing Kong, Luis Fernández-Sánchez, Estíbaliz Merino, Cristina Nevado*. Cyclization cascades via N-amidyl radicals toward highly functionalized heterocyclic scaffolds. J. Am. Chem. Soc. 2015, 137, 964-973. (Highly Cited Paper)
13. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Arylphosphonylation and arylazidation of activated alkenes. Angew. Chem. Int. Ed. 2014, 53, 5078-5082. (Chosen by the Editors as a “Hot Paper”) (Highly Cited Paper)
12. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Divergent reaction mechanism in the aminofluorination of alkenes. CHIMIA International Journal for Chemistry, 2014, 68, 430-435.
11. Wangqing Kong, Maria Casimiro, Noelia Fuentes, Estíbaliz Merino, Cristina Nevado*. Metal-free aryltrifluoromethylation of activated alkenes. Angew. Chem. Int. Ed. 2013, 52, 13086-13090. (Highly Cited Paper)
10. Wangqing Kong, Maria Casimiro, Estibaliz Merino, Cristina Nevado*. Copper-catalyzed 1-pot trifluoromethylation/arylmigration/desulfonylation and Csp2-N bond formation of conjugated tosyl amides. J. Am. Chem. Soc. 2013, 135, 14480-14483. (Highly Cited Paper)
9. Wangqing Kong, Pascal Feige, Teresa de Haro, Cristina Nevado*. Regio- and enantioselective aminofluorination of alkenes. Angew. Chem. Int. Ed. 2013, 52, 2469-2473. (Highlighted by Synfacts 2013, 9 (4), 371 and Organic Chemistry Portal 2014, March 17.) (Highly Cited Paper)
8. Wangqing Kong, Youai Qiu, Xue Zhang, Chunling Fu, Shengming Ma*. Exclusive 1,2-aryl shift in Platinum(II) chloride-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols. Adv. Synth. Catal. 2012, 354, 2339-2347.
7. Wangqing Kong, Chunling Fu, Shengming Ma*. Efficient synthesis of carbazoles via PtCl2-catalyzed RT cyclization of 1-(indol-2-yl)-2,3-allenols: scope and mechanism. Org. Biomol. Chem. 2012, 10, 2164-2173.
6. Wangqing Kong, Chunling Fu, Shengming Ma*. General Au-catalyzed benzannulation towards naturally occurring carbazole alkaloids from methoxypropadiene. Chem. Eur. J. 2011, 17, 13134-13137.
5. Wangqing Kong, Binjie Guo, Chunling Fu, Shengming Ma*. An efficient approach to 2-bromoalken-3-ols by regioselective bromohydroxylation reaction of simple allenes with NBS. Eur. J. Org. Chem. 2011, 2278-2285.
4. Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of polysubstituted naphthalene derivatives by gold-catalyzed cyclization of 1-arylalka-2,3-dienyl acetates. Eur. J. Org. Chem. 2010, 6545-6555.(Cover Story)
3. Wangqing Kong, Jie Cui, Yihua Yu, Guofei Chen, Chunling Fu, Shengming Ma*. PtCl4-catalyzed cyclization reaction of β-allenols in the presence of indole. Org. Lett. 2009, 11, 1213-1216.
2. Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of carbazoles from PtCl2-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols. Chem. Commun. 2009, 4572–4574.
1. Wangqing Kong, Chunling Fu, Shengming Ma*. Indium and zinc-mediated Barbier-type addition reaction of 2,3-allenals with allyl bromide: an efficient synthesis of 1,5,6-alkatrien-4-ols. Org. Biomol. Chem. 2008, 6, 4587–4592.


专利
1.一种合成咔唑类化合物的方法，专利号：ZL 200910099482.X
2.一种合成咔唑类生物碱 Siamenol 的方法，专利号：ZL 201110283659.9
3.一种合成天然咔唑类生物碱的制备方法，专利号：ZL 201110283147.2
4.一种合成咔唑类化合物的方法，专利号：ZL 201210516430.X