四川大学化学学院刘小华

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刘小华，四川大学教授，主要从事不对称合成方法学及生理活性化合物的合成研究。目前研究工作集中在新型手性双功能胍-酰胺和胺类配体和催化剂的设计合成，基于双活化策略、胍基的碱性及氢键活化模式，在温和条件下，高效高选择性地实现了多个不对称催化反应。
作为第二完成人获2009年教育部自然科学奖一等奖和2012年国家自然科学二等奖。获国家自然科学基金委优秀青年基金和教育部新世纪优秀人才支持计划资助，获德国Thieme Chemistry Journals Award 2013。
专      业  有机化学
电      话  028-85418249
E-Mail  liuxh@scu.edu.cn
简  历
1996年－2000年于湖北师范学院化学系学习，获理学学士学位。
2000年－2003年于四川大学化学学院分析化学专业学习，获理学硕士学位。
2003年－2006年于四川大学化学学院有机化学专业学习，获理学博士学位。
2006年－2010年，四川大学化学学院副教授，硕士生导师。
2010年－至今，四川大学化学学院教授，2012年担任博士生导师。
主要研究方向
主要从事不对称合成方法学及生理活性化合物的合成研究。

代表性成果 （获奖成果、专著、论文、专利）
1.Shunxi Dong, Xiaohua Liu*, Yin Zhu, Peng He, Lili Lin, Xiaoming Feng*, Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones, J. Am. Chem. Soc. 2013, 135, 10026-10029.
2.Jing Wang, Xiaohua Liu*, Shunxi Dong, Lili Lin, Xiaoming Feng*, Asymmetric Organocatalytic Cyclopropanation of Cinnamone Derivatives with Stabilized Sulfonium Ylides, J. Org. Chem. 2013, 78, 6322-6327.
3.Zhenling Chen, Lili Lin, Min Wang, Xiaohua Liu*, Xiaoming Feng*, Asymmetric Synthesis of trans-β-Lactams by a Kinugasa Reaction on Water, Chem. Eur. J. 2013, 19, 7561–7567.
4.Min Wang, Xiaohua Liu*, Peng He, Lili Lin, Xiaoming Feng*, Enantioselective Synthesis of 1,2,4-Triazolines by Chiral Iron(II)-Complex Catalyzed Cyclization of α-Isocyano Esters and Azodicarboxylates, Chem. Commun. 2013, 49, 2572–2574.
5.Yang Yang, Shunxi Dong, Xiaohua Liu*, Lili Lin, Xiaoming Feng*, Chiral Guanidine-Catalyzed Asymmetric Direct Vinylogous Michael Reaction of α,β-Unsaturated γ-Butyrolactams with Alkylidene Malonates, Chem. Commun. 2012, 48, 5040–5042.
6.Yangbin Liu, Xiaohua Liu*, Min Wang, Peng He, Lili Lin, Xiaoming Feng*, Enantioselective Synthesis of 3,4-Dihydropyran Derivatives via Organocatalytic Michael Reaction of α,β-Unsaturated Enones, J. Org. Chem. 2012, 77, 4136–4142.
7.Xiao Xiao, Xiaohua Liu*, Shunxi Dong, Yunfei Cai, Lili Lin, Xiaoming Feng*, Asymmetric Synthesis of 2,3-Dihydroquinolin-4-one Derivatives Catalyzed by Chiral Bisguanidium Salt, Chem. Eur. J. 2012, 18, 15922–15925.  
8.Xiaohua Liu, Lili Lin, Xiaoming Feng*, Chiral N,N'-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions, Acc. Chem. Res. 2011, 44, 574–587.
9.Shunxi Dong, Xiaohua Liu*, Yulong Zhang, Lili Lin, and Xiaoming Feng*, Asymmetric Synthesis of 3,4-Diaminochroman-2-ones Promoted by Guanidine and Bisguanidium Salt, Org. Lett. 2011, 13, 5060–5063.  
10.Jing Wang, Wentao Wang, Xiaohua Liu*, Zongrui Hou, Lili Lin, Xiaoming Feng*, Highly Enantioselective Direct Michael Addition of 1H-Benzotriazole to Chalcones Catalyzed by Sc(OTf)3/N,N-Dioxide Complex, Eur. J. Org. Chem. 2011, 2039–2042.  
11.Xiaohong Chen, Shunxi Dong, Zhen Qiao, Yin Zhu, Mingsheng Xie, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Guanidine Organocatalyst for the Asymmetric Mannich-Type Reaction between α-Isothiocyanato Imide and Sulfonyl Imines, Chem. Eur. J. 2011, 17, 2583–2586.
12.Min Wang, Lili Lin, Jian Shi, Xiaohua Liu*, Yulong Kuang, Xiaoming Feng*, Asymmetric Crossed-Conjugate Addition of Nitroalkenes to Enones by a Chiral Bifunctional Diamine Organocatalyst, Chem. Eur. J. 2011, 17, 2365–2368.
13.Peng He, Xiaohua Liu*, Jian Shi, Lili Lin, Xiaoming Feng*, Organocatalytic Sequential Michael Reactions: Stereoselective Synthesis of Multifunctionalized Tetrahydroindan Derivatives, Org. Lett. 2011, 13, 936-939.
14.Zhenhua Dong, Xiaohua Liu*, Juhua Feng, Min Wang, Lili Lin, Xiaoming Feng*, Efficient Asymmetric Synthesis of 4H-Chromene Derivatives through a Tandem Michael Addition– Cyclization Reaction Catalyzed by a Salen–Cobalt(II) Complex, Eur. J. Org. Chem. 2011, 137–142.
15.Xuan Fu, Juhua Feng, Zhenhua Dong, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Enantioselective Synthesis of 2-Substituted-1,5-Benzodiazepines through Domino Reaction of o-Phenylenediamine and Chalcone Derivatives, Eur. J. Org. Chem. 2011, 5233–5236.
16.Yonghai Hui, Weiliang Chen, Wentao Wang, Jun Jiang, Yunfei Cai, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Highly Enantioselective Zinc-Catalyzed Friedel–Crafts Alkylation of Indoles with Ethyl Trifluoropyruvate, Adv. Synth. Catal. 2010, 352, 3174–3178.
17.Lin Zhou, Lili Lin, Wentao Wang, Jie Ji, Xiaohua Liu*, Xiaoming Feng*, Highly Enantioselective Michael Addition of Malonates to β,γ-Unsaturated α-Ketoesters Catalyzed by Chiral N,N'-dioxide-Yttrium(III) Complexes with Convenient Procedure, Chem. Commun. 2010, 46, 3601–3603.
18.Qi Zhang, Yonghai Hui, Xin Zhou, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Highly Efficient Asymmetric Three-Component Vinylogous Mannich Reaction Catalyzed by a Chiral Scandium(III)-N,N'-Dioxide Complex, Adv. Synth. Catal. 2010, 352, 976–980.
19.Xiaohua Liu, Lili Lin, Xiaoming Feng*, Amide Based Bifunctional Organocatalysts in Asymmetric Reactions (Feature Article), Chem. Commun. 2009, 6145–6158.  
20.Xiaohua Liu, Bo Qin, Bin He, and Xiaoming Feng*, Catalytic Asymmetric Cyanosilylation of Ketones by a Chiral Amino Acid Salt, J. Am. Chem. Soc. 2005, 127, 12224-12225.

shuncha

  4月29日，由全国妇联、中国科协、中国联合国教科文组织全国委员会及欧莱雅中国共同举办的第十五届“中国青年女科学家奖”颁奖典礼在北京举行，10位在医学、生物学、地球科学、航天科学等科研领域中表现卓越的女性获得这一奖项。我院刘小华教授是我省唯一一名上榜人员。
      全国妇联主席沈跃跃，全国妇联副主席、书记处第一书记黄晓薇，中国科协常务副主席、书记处第一书记怀进鹏，全国妇联副主席、书记处书记吴海鹰，北京大学常务副校长、中国科学院院士詹启敏，中国联合国教科文组织全国委员会秘书长秦昌威，欧盟驻华大使郁白，欧莱雅中国首席执行官费博瑞，欧莱雅中国副总裁兰珍珍等出席颁奖典礼并为获奖女科学家颁奖。中国科协书记处书记束为主持颁奖典礼。
      刘小华老师主要从事不对称有机合成方面的研究工作。“有机化学研究，很多时间是必须投在实验室里的，离开了实验室就很难出成果，难免要牺牲很多本该属于家人的时间。”刘小华说，“女科学家若要达到同样的科研高度，要比男性付出和牺牲更多。”
       据悉，本届“中国青年女科学家奖”评审委员会由39位来自全国的院士、专家组成，经过严格的评审，10位青年女科学家获奖者从116个单位提名的224位有效候选人中脱颖而出。迄今为止，中国青年女科学家奖已评选表彰了15届，共有134名优秀女科技工作者获奖，已成为我国发现和举荐高层次女性科技人才的一个重要平台。