四川大学化学学院余孝其

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余孝其，四川大学教授。中国化学会化学生物学专业委员会委员、中国监控化学品协会技术专家库成员。是50余种国际国内重要刊物的论文评审专家，包括Angew. Chem Int. Ed.、J. Am. Chem. Soc.、J. Org. Chem.、Org. Lett.、Chem. Commun.、Tetrahedron、Tetrahedron Lett.等国际化学领域主流期刊。主要研究方向为：有机化学专业（生物有机化学）、化学生物学专业（生物材料化学） 、绿色化学专业（绿色合成方法学）。2000年四川省做出突出贡献的博士学位获得者，2003年入选四川省杰出青年学科带头人培养计划，2003年入选教育部新世纪优秀人才资助计划，2006年四川省学术和技术带头人，2006年享受国务院政府特殊津贴专家，2007年国家杰出青年基金获得者 ， 2009年入选国家七部委新世纪百千万人才工程国家级人选，2009年教育部**学者特聘教授。2000年12月 货校级优秀教学成果二等奖，2001年7月获四川省科技进步三等奖， 2006年7月四川省科技进步二等奖，2010年11月获教育部高等学校科学研究优秀成果奖自然科学一等奖， 2012年8月四川省科技进步二等奖，2012年9月四川大学教学成果奖一等奖。共发表论文260余篇，其中SCI收录210余篇。


余孝其
职称与职务  教授、博士生导师
专      业  有机化学
电      话
E-Mail
学习及工作经历
余孝其，男， 1965 年 7 生于四川资中。
一、学习经历
1983.09-1987.07, 四川大学化学系读本科
1987.09-1993.03, 四川大学化学系有机专业攻读硕士、博士学位。
二、工作经历
1993.04-1994.09: 四川大学化学系任讲师
1994.10-1999.06: 四川大学化学系任副教授
1998.04-2001.03: 香港大学化学系支志明院士研究室 Research Associate
1999.07- 至今： 四川大学化学学院教授
2001.07- 至今： 四川大学化学一级学科点博士生导师
2003.12- 至今： 绿色化学与技术教育部重点实验室副主任
2008- 至今：四川大学二级教授
三、社会兼职
中国化学会化学生物学专业委员会委员
中国监控化学品协会技术专家库成员
四川省禁化武技术专家


主要研究方向
招收博、硕士研究生方向：
1 、化学生物学（生物催化）
2 、有机化学（生物有机化学）
3 、绿色化学（绿色合成方法学）
主要工作业绩
2000 年：四川省做出突出贡献的博士学位获得者
2003 年：入选 四川省杰出青年学科带头人培养计划
2003 年：入选教育部新世纪优秀人才资助计划
2006 年：四川省学术和技术带头人
2006 年：享受国务院政府特殊津贴专家
2007 年：国家杰出青年基金获得者
2009 年： 入选国家七部委新世纪百千万人才工程国家级人选
2009 年：教育部长江学者特聘教授
奖励
1. 四川省科技进步三等奖，生物功能体系的分子模拟，谢如刚，余孝其，游劲松，鄢家明，罗美明，苏晓渝，向清祥， 2001 年 7 月。
2. 2000 年校级优秀教学成果二等奖，理科大学生实践能力培养研究 ------ 基础有机化学实验的课程体系改革研究，汪庆华，孙滨，杨祖幸，蒋小双，刘国凤，王玉良，余孝其， 2000 年 12 月
3. 四川省科技进步二等奖，金属胶束模拟水解金属酶的研究，曾宪诚，余孝其，孟祥光，寇兴明，杜娟，胡常伟， 2006 年 7 月


代表性成果 （获奖成果、专著、论文、专利）
共发表论文 200 余篇，其中 SCI 收录 140 余篇。近五年发表的部分论文：
(1). Chen, X., Huang, Z., Chen, S.-Y., Li, K., Yu, X.-Q.* , Pu, L.*, Enantioselective Gel Collapsing: A New Means of Visual Chiral Sensing, J. Am. Chem. Soc. , 2010 , 132 , 7297–7299.
(2). Wen, J., Qin, S., Ma, L.-F., Dong, L., Zhang, J., Liu, S.-S., Duan, Y.-S., Chen, S.-Y., Hu, C.-W.*, Yu, X.-Q.* , Iron-Mediated Direct Suzuki - Miyaura Reaction: A New Method for the ortho -Arylation of Pyrrole and Pyridine, Org. Lett. , 2010 , 12 , 2694 - 2697.
(3). Xiang, Y.-Z., Feng, Z.-H., Zhang, J.*, Liao, Y.-L., Yu, C.-J., Yi, W.-J., Zhu, W.*, Yu, X.-Q.* , Linear cyclen-based polyamine as a novel and efficient reagent in gene delivery, Org. Biomol. Chem. , 2010 , 8 , 640–647.
(4). Chen, X., Chen, W., Wang, L., Yu, X.-Q. * , Huang, D.-S., Pu, L. *, Synthesis of a C 1 symmetric BINOL–terpyridine ligand and highly enantioselective methyl propiolate addition to aromatic aldehydes, Tetrahedron , 2010 , 66 , 1990–1993.
(5). Chen, X., Liu, Q., Sun, H.-B., Yu, X.-Q. * , Pu, L. *, A BINOL–terpyridine-based multi-task catalyst for a sequential oxidation and asymmetric alkylation of alcohols, Tetrahedron Lett. , 2010 , 51 , 2345–2347 .
(6). Huang, Y., Liu, J.-L., Zhang, J., Liu, Q., Hou, J.-T., Zhang, Y., Zhang, D.-W., Lu, Q.-S., Chen, S.-Y., Lin, H.-H.*, Yu, X.-Q.* , Interaction of bis-aryl functionalized molecules with nucleosides and nucleic acids , Sci. China Chem. , 2010 , 53 , 103–112.
(7). Zhou, L.-H., Yu, X.-Q. * , Pu, L. * , Reactivity of a propiolate dimer with nucleophiles and an efficient synthesis of dimethyl a-aminoadipate, Tetrahedron Lett. , 2010 , 51 , 425–427.
(8). Zhou, L.-H., Yu, X.-Q. * , Pu, L. * , Na-promoted aerobic oxidation of alcohols to ketones, Tetrahedron Lett. , 2010 , 51 , 475–477.
(9). Meng, X.-W., Qin, J., Liu, Y., Fan, M.-M., Li, B.-J.* , Zhang, S.* , Yu, X.-Q. , Degradable hollow spheres based on self-assembly inclusion, Chem. Commun. , 2010 , 46 , 643–645.
(10). Liu, P.-Y. , Li, K.* , Zhang, J. , Zhang, D.-W. , Lin, H.-H.* , Yu, X.-Q.* , Who Is the King? The a -Hydroxy- b -oxo- a , b -enone Moiety or the Catechol B Ring: Relationship between the Structure of Quercetin Derivatives and Their Pro-Oxidative Abilities, Chem. Biodivers. , 2010 , 7 , 236-244.
(11). Zhang, J., Meng, X.-G., Zeng, X.-C., Yu, X.-Q.* , Metallomicellar supramolecular systems and their applications in catalytic reactions, Coord. Chem. Rev. , 2009 , 253, 2166–2177.
(12). Yue, Y., Yu, X.-Q.* , Pu, L.*, Base-Catalyzed Highly Stereoselective Conversion of g -Hydroxy- a,b -acetylenic Esters to g -Acetoxy Dienoates, Chem. Eur. J. , 2009 , 15 , 5104-5107.
(13). Lu, Q.-S., Dong, L., Zhang, J., Li, J., Jiang, L., Huang, Y., Qin, S., Hu, C.-W., Yu, X.-Q.* , Imidazolium-Functionalized BINOL as a Multifunctional Receptor for Chromogenic and Chiral Anion Recognition, Org. Lett. , 2009 , 11 , 669-672.
(14). Li, K., He, T., Li, C., Feng, X.-W., Wang, N., Yu, X.-Q.* , Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity to C-C bond formation in a “one-pot” synthesis, Green Chem. , 2009 , 11 , 777-779.
(15). Zhou, L.-H., Yu, X.-Q.* , Pu, L.*, Reactivity of γ -Hydroxy- α,β -acetylenic Esters with Amines: Facile Synthesis of the Optically Active 4-Amino-2(5 H )-furanones, J. Org. Chem. , 2009 , 74 , 2013–2017.
(16). Huang, Y., Zhang, Y., Zhang, J., Zhang, D.-W., Lu, Q.-S., Liu, J.-L., Chen, S.-Y., Lin, H.-H.*, Yu, X.-Q.* , Synthesis, DNA binding and photocleavage study of novel anthracene-appended macrocyclic polyamines, Org. Biomol. Chem. , 2009 , 7 , 2278-2285.
(17). Wu, B., Wen, J., Zhang, J., Li, J., Xiang, Y.-Z., Yu, X.-Q.* , One-Pot Van Leusen Synthesis of 4,5-Disubstituted Oxazoles in Ionic Liquids, Synlett , 2009 , (3) , 500-504.
(18). Zhou, L.-H., Yang. M., Zhou, H.*, Zhang, J., Li, K., Xiang, Y.-Z., Wang, N., Tian, Y.-F., Yu, X.-Q.* , Novel Reticular Cyclen-Based Polymer as Gene Vector in DNA Transfection, Chem. Biol. Drug Des. , 2009 ; 73 , 216–224.
(19). Wang, H.-Y., Li, C., Wang, N.*, Li, K., Feng, X.-W., He, T., Yu, X.-Q.*, Two-step enzymatic selective synthesis of water-soluble ketoprofen -saccharide conjugates in organic media, Bioorg. Med. Chem. , 2009 , 17 , 1905-1910.
(20). Xiang, Y.-Z., Wang, N., Zhang, J., Li, K., Zhang, Z.-W., Lin, H.-H.*, Yu, X.-Q.* , Novel Cyclen-Based Linear Polymer as a High-Affinity Binding Material for DNA Condensation, SCI China B , 2009 , 52 , 483-488.
(21). Xiang, Y.-Z., Zhou, L.-H., Jiang, N., Lin, H.-H.*, Yu, X.-Q.* , Synthesis of a novel linear polymer of macrocyclic polyamine copper (II) complex and its interaction with plasmid DNA, J. Enzyme Inhibition Med. Chem ., 2009 , 24, 315-319.
(22). Huang, Y., Chen, S.-Y., Zhang, J., Tan, X.-Y., Jiang, N., Zhang, J.-J., Zhang, Y., Lin, H.-H.*, Yu, X.-Q.* , Dinuclear copper (II) complexes of macrocyclic polyamines: Synthesis, characterization and DNA cleavage , Chem. Biodivers. , 2009 , 6 , 475-486.
(23). Li , K. , Wang , N . , Yang , F . , Zhang , Z . -W . , Zhou , L . -H . , Chen , S . -Y . , Lin , H . -H .* , Tian , Y . -F . , Yu , X . -Q . * , Cyclen- b ased side-chain homop olymer self-assembly with plasmid DNA : Protect ion of DNA from enzymatic degradation , Chem. Biodivers., 200 9 , 6 , 754-763 .
(24). Li, K., Zhou, L.-H., Zhang, J., Chen, S.-Y., Zhang, Z.-W., Zhang, J.-J., Lin, H.-H.*, Yu, X.-Q.* , “Self-activating” Chemical Nuclease: Ferrocenyl Cyclen Cu( II ) Complexes Act as Efficient DNA Cleavage Reagents in the Absence of Reductant, Eur. J. Med. Chem. , 2009 , 44 , 1768-1772.
(25). Yang, X.-B., Wang, L., Zhang, J., Zhang, Z.-W., Lin, H.-H.*, Zhou, L.-H., Yu, X.-Q.* , A New Schiff Base Copper (II) Complex Derived from Estrone and D-Glucosamine: Synthesis, Characterization and Its Interaction with DNA, J. Enzyme Inhibition Med. Chem. , 2009 , 23 , 125-130.
(26). Li, K., Zhang, J., Zhang, Z.-W., Xiang, Y.-Z., Lin, H.-H., Yu, X.-Q.* , Immobilization Cyclen Copper (II) on Merrifield Resin: Efficient Oxidative Cleavage of Plasmid DNA , J. Applied Polym. Sci. , 2009 , 111 , 2485-2492.
(27). Xiang, Y.-Z., Liao, Y.-L., Zhang, J.*, Zhang, D.-W., Chen, S.-Y., Lu, Q.-S., Zhang, Y., Lin, H.-H,*, Yu, X.-Q.* , Linear disulfide-containing low polymer as efficient DNA cleavage reagent , Bioorg. Med. Chem. Lett. , 2009 , 19 , 3458–3460.
(28). Wang, L., Zhang, J., Wang, N., Yang, X.-B., Wang, Q., Yu, X.-Q.* , Asymmetric Catalysis of Diels-Alder Cycloaddition of 2-Alkenoyl Pyridine with Cyclopentadiene by Binaphthol-Titanium Complex , Lett. Org. Chem., 2009 , 6, 392-396.
(29). Lu , Q.-S. , Huang, Y. , Li, J. , Zhang, Z.-W. , Lin, H.-H.* , Yu, X.-Q.* , The Effect of an Amino-Acid Bridge on Binding Affinity and Cleavage Efficiency of Pyrenyl-Macrocyclic Polyamine Conjugates toward DNA, Chem. Biodivers., 2009 , 6 , 1273-1282.
(30). Qin, J., Zhang, J., Wu, B., Zheng, Z.-G., Yang, M., Yu, X.-Q.* , Efficient and Mild Protocol for the Synthesis of 4(3)-Substituted 3(4)-Nitro-1 H -pyrroles and 3-Substituted 4-Methyl-2-tosyl-1 H pyrroles from Nitroolefins and Tosylmethyl Isocyanide in Ionic Liquids , Chinese J. Chem. , 2009 , 27 , 1782 - 1788.
(31). Li, J., Zhang, J., Lu, Q.-S., Yue, Y., Huang, Y., Zhang, D.-W., Lin, H.-H., Chen, S.-Y., Yu, X.-Q. * , Hydrolytic cleavage of DNA by urea-bridged macrocyclic polyamines, Eur. J. Med. Chem. , 2009 , 44 , 5090–5093.
(32). Chen, S.-Y., Zhang, J., Li, Y.-H., Wen, J., Bian, S.-Q., Yu, X.-Q. * , Cobalt-catalyzed homo-coupling of aryl and alkenyl bromide using atmospheric oxygen as oxidant, Tetrahedron Lett. , 2009 , 50 , 6795–6797.
(33). Feng, X.-W., Li, C., Wang, N.*, Li, K., Zhang, W.-W., Wang, Z., Yu, X.-Q.* , Lipase-catalysed decarboxylative aldol reaction and decarboxylative Knoevenagel reaction , Green Chem. , 2009 , 11 , 1933-1936.
(34). Yue, Y, Turlington, M., Yu, X.-Q.* , Pu, L.*, 3, 3' -Anisyl-Substituted BINOL, H4BINOL, and H8BINOL Ligands: Asymmetric Synthesis of Diverse Propargylic Alcohols and Their Ring-Closing Metathesis to Chiral Cycloalkenes, J. Org. Chem. , 2009 , 74 , 8681-8689.
(35). Wen, J., Zhang, J., Chen, S.-Y., Li, J., Yu, X.-Q.* , Iron-Mediated Direct Arylation of Unactivated Arenes, Angew. Chem. Int. Ed. , 2008 , 47 , 8897-8900.
(36). Zheng, Z.-G., Wen, J., Wang, N., Wu, B., Yu, X.-Q.* , N-Arylation of amines, amides, imides and sulfonamides with arylboroxines catalyzed by simple copper salt/EtOH system , Beilstein J. Org. Chem., 2008 , 4 , No. 40. doi:10.3762/bjo c.4.40
( 37 ). Li, C., Feng , X . -W . , Wang , N . , Zhou , Y . -J ., Yu , X . -Q . * , Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction, Green Chem. , 2008 , 10 , 616-618 .
(38). Yang, X.-B., Feng, J., Zhang, J., Wang, N., Wang, L., Liu, J.-L., Yu, X.-Q* , Highly Enantioselective Hetero-Diels ?- Alder Reaction of trans-1-Methoxy-2-methyl-3-trimethylsiloxybuta-1,3-diene with Aromatic and Aliphatic Aldehydes Catalyzed by 3-Substituted BINOL - Titanium Complex, Org. Lett. , 2008 , 10 , 1299-1302.
(39). Huang, Y., Lu, Q.-S., Zhang, J., Zhang, Z.-W., Zhang, Y., Chen, S.-Y., Li, K., Tan, X.-Y., Lin, H.-H.* , Yu, X.-Q. * , DNA cleavage by novel copper (II) complex and the role of b -cyclodextrin in promoting cleavage , Bioorg. Med. Chem. , 2008 , 16 , 1103-1110.
(40). Yang, X.-B., Feng, J., Zhang, J., Zhang, Z.-W., Lin, H.-H.* , Zhou, L.-H. , Yu, X.-Q. * , Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine conjugates , Bioorg. Med. Chem. , 2008 , 16 , 3871-3877.
(41). Yang, F., Wang, L., Li, X., Shen, J., Wang, J., Yu, X.-Q.* , Improved Preparation of Nabumetone by Raney Ni Catalytic Hydrogenation , Lett. Org. Chem., 2008 , 5, 191-193.
(42). Huang, Q.-D., Chen, H., Zhou, L.-H., Huang, J., Wu, J., Yu X.-Q.* , A Novel Macrocyclic Polyamine Cationic Lipid Containing an Imidazolium Salt Group: Synthesis, Characterization and Its Transfection Activity as a Gene Delivery Vector, Chem. Biol. Drug. Des. , 2008 ; 71 , 224-229
(43). Tao, L., Yue, Y., Zhang, J., Chen, S.-Y., Yu, X.-Q.* , A Mild and Efficeint Method for N -Arylnucleobase Synthesis via the Cross-Coupling Reactions of Nucleobases with Arylboronic Acids Catalyzed by Simple Copper Salts , Helv. Chim. Acta , 2008 , 91 , 1008-1014.
(44). Wang, G.-Q., Zhang, J., Luo, S.-Z., Wang, N., Wei, H.-Y., Wang, W.-J., Yang, Y.-Q., Liu, G.-P., Yu, X.-Q.* , Synthesis and Primary Biological Evaluation of 188 ReN-NEMPTDD , J. Radioanaly. Nucl. Chem. , 2008 , 277 , 365-369.
(45). Zhao, Y.-C., Zhang, J., Wang, N., Yu, H., Yang, X.-B., Chen, S.-Y., Yu, X.-Q.* , Enantioselective Synthesis of 2, 6-Disubstituted Dihydropyrone Derivatives Catalyzed by TiCl 4 /BINOL/RONa System, Lett. Org. Chem. , 2008 , 5 , 391-395.
(46). Li, J., Yue, Y., Zhang, J., Lu, Q.-S., Li, K., Huang, Y., Zhang, Z.-W., Lin, H.-H.*, Wang, N., Yu, X.-Q. *, “Arm” effects of mononuclear cyclen copper complexes on DNA cleavage , Transit. Metal Chem. , 2008 , 33 , 759-765.
(47). Li, K., Zhang, J., Zhang, J.-J., Zhang, Z.-W., Zhuang, Z.-J., Xiao, D., Lin, H.-H.*, Yu, X.-Q.* , Ferrocene-Bridging Dinuclear Cyclen Copper( II ) Complexes as High Efficient Artificial Nucleases: Design, Synthesis and Interaction with DNA , Applied Organometal. Chem. , 2008 , 22 , 243-248.
(48). Li, C., Wang, H.-Y. Wang, N., * Fang, Y.-G., Chen, X., Yu, X.-Q. * , Highly regioselective enzymatic synthesis of polymerizable derivatives of methyl shikimate, Bioorg. Med. Chem. Lett. , 2007 , 17 , 6687-6690.
(49). Wang, R ., Lu, X. X .*, Yu, X. Q . *, Shi, L ., Sun, Y ., Acid-catalyzed solvent-free synthesis of 2-arylbenzimidazoles under microwave irradiation, J. Mol. Catal. A-Chem . 2007 , 266 (1-2) , 198-201.
(50). Tao, K ., Yu, X. Q .* , Liu, Y ., Shi, G. Y ., Liu, S. G ., Hou, T. P .*, Cloning, expression, and purification of insecticidal protein Pr596 from locust pathogen Serratia marcescens HR-3, Current Microbiology , 2007 , 55 (3) , 228-233.
(51). Huang, J., Huang, Q.-D., Zhang, J., Zhou, L.-H., Li, Q.-L., Li, K., Jiang, N., Lin, H.-H.*, Wu, J., Yu, X.-Q.* , Dinuclear Zinc (II) Complexes of Macrocyclic Polyamine Ligands Containing an Imidazolium Bridge: Synthesis, Characterization, and Their Interaction with Plasmid DNA, Int. J. Mol. Sci. 2007 , 8 , 606-617.
(52). He, L., Yu, J., Zhang, J., Yu, X.-Q.* , a -Amidation of cyclic ethers catalyzed by simple copper salts and a mild and efficient preparation method for a , v -aminoalcohols, Org. Lett. , 2007 , 9 , 2277-2280.
(53). Wang, Q., Chen, X., Tao, L., Wang, L., Xiao, D., Yu, X.-Q.* , Pu, L.*, Enantioselective Fluorescent Recognition of Amino Alcohols by a Chiral Tetrahydroxyl 1, 1' -Binaphthyl Compound, J. Org. Chem. , 2007 , 72, 97-101.
(54). Fang, Y.-G., Zhang, J., Chen, S.-Y., Jiang, N. , Lin, H.-H.*, Zhang, Y., Yu, X.-Q.* , Chiral multinuclear macrocyclic polyamine complexes: Synthesis, characterization and their interaction with plasmid DNA , Bioorg. Med. Chem. , 2007 , 15, 696-701.
(55). Wang, Q., Chen, S.-Y., Yu, X.-Q.* , Pu, L.*, 1, 1' -Binaphthyl ligands with bulky 3, 3' -tertiaryalkyl substitutes for the asymmetric alkyne addition to aromatic aldehydes, Tetrahedron , 2007 , 63, 4422-4428 .
(56). Zhao, Y.-C., Zhang, J., Huang, Y., Wang, G.-Q., Yu, X,-Q.* , DNA cleavage promoted by 2, 9-dimethyl-4, 7-diazadecane-2, 9-dithiol (DMDD) derivatives, Bioorg. Med. Chem. Lett. , 2007 , 17 , 2745-2748.
(57). Tan, X.-Y., Zhang, J., Huang, Y., Zhang, Y., Zhou, L.-H., Jiang, L., Lin, H.-H.*, Wang, N., Xia, C.-Q., Yu, X.-Q.* , Synthesis and DNA cleavage activities of the zinc(II), copper(II) and cobalt(II) complexes of benzocrown ether-fuctionalized 1,4,7,10-tetraazacyclododecane, Chem. Biodivers. , 2007 , 4 (9), 2190-2197.
(58). Liu, P.-Y., Jiang, N., Zhang, J., Wei, X., Lin, H.-H.*, Yu, X.-Q.* , The oxidative damage of plasmid DNA by ascorbic acid derivatives in vitro: The first research on the relationship between the structure of ascorbic acid and the oxidative damage of plasmid DNA, Chem. Biodivers. 2006 , 958-966.
(59). Gao, G., Wang, Q., Yu, X.-Q.* , Xie, R.-G., Pu, L.*, Highly Enantioselective Synthesis of g -Hydroxy- a , b -acetylenic Esters by Asymmetric AlkyneAddition to Aldehydes, Angew. Chem. Int. Ed. 2006 , 45 , 122-125.
(60). Zhao, Y.-C., Xiang, Y.-Z., Pu, L., Yang, M., Yu, X.-Q.* , Highly ? b ? - Selective Epoxidation of the D 5 - and D 4 -Unsaturated Steroids Catalyzed by the Silica-Supported Polyhalogenated Ruthenium Porphyrin , Applied Catal. A: General , 2006 , 301 , 176-181.
(61). Li, Q.-L., Huang, J., Wang, Q., Jiang, N., Xia, C.-Q., Lin, H.-H., Wu, J. ,* Yu, X.-Q. * , Monometallic complexes of 1,4,7,10-tetraazacyclododecane containing an imidazolium side: Synthesis, characterization, and their interaction with plasmid DNA, Bioorg. Med. Chem. , 2006 , 14 , 4151–4157.
(62). Xia, C.-Q., Jiang, N., Zhang, J., Chen, S.-Y., Lin, H.-H.*, Tan, X.-Y., Yue, Y., Yu, X.-Q.* , The Conjugates of Uracil-Cyclen Zn (II) Complexes: Synthesis, Characterization and Their Interaction with Plasmid DNA , Bioorg. Med. Chem. , 2006 , 14 , 5756-5764.
(63). Wang, X.-Y., Zhang, J., Li, K., Jiang, N., Chen, S.-Y., Lin, H.-H.*, Huang, Y., Ma, L.-J., Yu, X.-Q.* , Synthesis and DNA cleavage activities of mononuclear macrocyclic polyamine zinc(II), copper(II), cobalt(II) complexes which linked with uracil , Bioorg. Med. Chem. , 2006 , 14 , 6745-6751.
(64). Zheng, L., Zhang, S., Yu, X. , Zhao, L., Gao, G., Yang, X., Duan, H., Cao, S. , Enhancement of enantioselectivity in lipase-catalyzed resolution of N -(2-ethyl-6-methylphenyl)alanine by additives, J. Mol. Catal. B: Enzym. 2006 , 38 , 17-23.
(65). Yu, Y., Zhou, W.-C., Zhang, J., Zhang, M., Xu, D.-Y., Tang, Y., Li, B.-G., Yu, X.-Q.* , Novel Synthetic Route of a Pivotal Intermediate for the Synthesis of 1 b -Methyl Carbapenem Antibiotics, Org. Process Res. Dev. , 2006 , 10 , 829-832.
(66). Jiang, F.-B., Huang, L.-Y., Meng, X.-G., Du, J., Yu, X.-Q.* , Zhao, Y.-F., Zeng, X.-C.*, Metallomicellar catalysis: Hydrolysis of phosphate monoester and phosphodiester by Cu(II), Zn(II) complexes of pyridyl ligands in CTAB micellar solution, J. Colloid Interface Sci. , 2006 , 303 , 236-242.
(67). Qiao, R.-Z., Zhang, Z., Ju, Y. , Xia, C.-Q., Yu, X.-Q. , Zhao, Y.-F., Electrospray Ionization Mass Spectral Characteristics of Polyamide Containing 1,4,7,10-Tetraazacyclododecane, Chinese J. Chem. , 2006 , 24 , 923-928.
(68). Yue, Y., Zheng, Z.-G., Wu, B., Xia, C.-Q., Yu X.-Q.* , Copper-Catalyzed Cross-Coupling Reactions of Nucleobases with Arylboronic Acids: An Efficient Access to N -Arylnucleobases, Eur. J. Org. Chem., 2005 , 5154–5157.
(69). Peng, W., Liu, P.-Y., Jiang, N., Lin, H.-H., Zhang, G.-L., Liu, Y., Yu, X.-Q.* , Dinuclear macrocyclic polyamine zinc(II) complexes linked with X exible spacers: Synthesis, characterization, and DNA cleavage, Bioorg. Chem. , 2005 , 33, 374–385.
(70). Xiang, Q.-X.; Zhang, J.; Liu, P.-Y.; Xia, C.-Q.; Zhou, Z.-Y.; Xie, R.-G.; Yu, X.-Q.* , Dinuclear macrocyclic polyamine zinc (II) complexes: Syntheses, characterization and their interaction with plasmid DNA, J. Inorg. Biochem. , 2005 , 99(8) , 1661-1669.
(71). Li, Z.-C.; Zhang, J.; Hu, W.-H.; Chen, Z.-Y.; Yu, X.-Q.* , Rhodium Acetate-Mediated Epoxidation from the Reaction of Diazobenzylphosphonates with Aldehydes and Ketones: A Convenient and Highly Steroselective Synthetic Method for cis-1,2-Epoxypropylphosphonates, Synlett , 2005 , (11) , 1711-1715.
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chuxin

除了细胞屏障的基本功能外，细胞膜在许多细胞行为中发挥着非常重要的作用，如细胞迁移、细胞扩散、神经通讯、细胞运输和信号级联等。此外，细胞膜异常对于细胞状态和许多疾病而言是一个重要的标志。因此，开发高选择性、高灵敏度的检测技术以准确对细胞膜进行可视化，尤其是活体可视化监测，对于探索与解决医学早期诊断和研究生物学中的基本问题具有重要意义。

       近日，四川大学余孝其课题组与韩国高丽大学Jong Seung Kim教授课题组合作，设计了一种基于聚集诱导发光特性的荧光探针，用于生物体内细胞膜快速、灵敏的免洗成像。探针以嘌呤骨架作为核心，装配疏水的烷基链与带有正电荷的季铵盐，在水中保持良好溶解性的同时使无发光特性；探针通过疏水相互作用与静电相互作用嵌入到细胞膜中，受到磷脂双分子层的限制激活RIR过程，从而可以被激发出明亮的荧光。
探针可以对多种细胞的细胞膜进行快速的免洗成像，并且在保持高信噪比的情况下较长时间的标记细胞膜；其优良的细胞膜靶向性与生物安全性使其可以快速无损的标记神经元细胞的细胞膜。此外，探针在多细胞肿瘤球中表现出良好的细胞间渗透性与细胞膜特异性，可在免洗的情况下较快地渗透120微米的细胞球，并标记出其蜂窝状的细胞膜结构。
       除了体外染色，探针也可以对活体斑马鱼进行染色。探针可以穿透常规染料无法渗入的斑马鱼表面的粘膜层，对其表皮细胞进行染色。此外，探针也可进入斑马鱼眼组织，对其眼部结构进行部分成像。
       上研究结果以论文形式发表在国际期刊《Angewandte Chemie International Edition》上，论文题目为“An AIE-Based Probe for Rapid and Ultrasensitive Imaging of Plasma Membranes in Biosystems”。论文的第一作者为四川大学化学学院博士生石磊，通讯作者为李坤教授、Jong Seung Kim教授和余孝其教授。近期，该课题组还深入研究了探针中疏水链的长度和电荷对其细胞膜靶向性能的影响（Bio-inspired assembly in a phospholipid bilayer: effective regulation of electrostatic and hydrophobic interactions for plasma membrane specific probes, Chem. Commun., 2020, 10.1039/d0cc00679c）。四川大学为本文的第一作者单位和通讯作者单位。该项研究工作得到了国家自然科学基金的经费支持。
        原文链接：
        https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201909498
        https://pubs.rsc.org/en/content/ ... 00679C#!divAbstract