西安交通大学成一龙

pangzi

成一龙，西安交通大学理学院特聘研究员，校“青年拔尖人才计划”入选者，博导。2008年于中国科学技术大学取得学士学位，2014年在中国科学院长春应用化学研究所取得博士学位，师从陈学思研究员。2014年至2017年在美国华盛顿大学生物工程系从事博士后研究工作，合作导师Suzie Pun教授。研究方向为生物医用高分子的合成及在基因和药物传递、组织工程领域的应用。目前在Angew. Chem. Int. Ed., Biomaterials, Small, J. Control. Release, Biomacromolecules, Polym. Chem.等国际主流学术期刊发表论文30余篇，授权中国专利10项，申请美国和国际专利各一项。

通信地址：西安交通大学理学院应化系  陕西省西安市咸宁西路28号
邮    编： 710049
电子邮箱： yilongcheng@mail.xjtu.edu.cn


Research Fields
1. 生物医用高分子材料的开发
2. 多功能水凝胶在组织工程领域的应用
3. 柔性电子传感器


2017.12-至今         西安交通大学化学学院         特聘研究员  博导
2014.1-2017.12     美国华盛顿大学                    博士后
2008.9-2014.1       中科院长春应化所                 博士
2004.9-2008.7       中国科学技术大学                 学士

发表论文：

2020年

45. Chen, X., Xu, K., Yu, J., Zhao, X., Zhang, Q., Zhang, Q., Zhang, Y., Cheng, Y.*, Peptide modified polycations with pH triggered lytic activity for efficient gene delivery, Biomater. Sci., 2020, DOI: 10.1039/D0BM01231A. (Invited article for 2021 Biomaterials Science Emerging Investigators)

44. Yang, Y., Zhao, X., Yu, J., Chen, X., Chen, X., Cui, C., Zhang, J., Zhang, Q., Zhang, Y., Wang, S.*, Cheng, Y.*, H-Bonding Supramolecular Hydrogels with Promising Mechanical Strength and Shape Memory Properties for Postoperative Antiadhesion Application, ACS Appl. Mater. Interfaces 2020, 12, 30, 34161–34169.

43. Chen, X., Zhong, Q., Cui, C., Ma, L., Liu, S., Zhang, Q., Wu, Y., An, L., Cheng, Y., Ye, S., Chen, X., Dong, Z., Chen, Q., Zhang, Y.*, Extremely Tough, Puncture-Resistant, Transparent, and Photoluminescent Polyurethane Elastomers for Crack Self-Diagnose and Healing Tracking, ACS Appl. Mater. Interfaces 2020, 12, 27, 30847–30855.

42. Zhang, Q., Kunag, G., He, S., Lu, H., Cheng, Y., Zhou, D.*, Huang, Y.*, Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian Cancer, Nano Lett. 2020, 20, 5, 3039–3049.

41. Zhao, X., Lei, H., Cheng, Y.*, Wu, Y., Zhang, M., He, G., Pei, D., Dong, Z., Li, A.*, Zhang, Y.*, A polymeric prodrug for non-invasive, real-time reporting drug release based on “turn-on” fluorescent probes, React. Funct. Polym. 2020, 154, 104649.

40. Yu, J., Chen, X., Yang, Y., Zhao, X., Chen, X., Jing, T., Zhou, Y., Xu, J., Zhang, Y.*, Cheng, Y.*, Construction of supramolecular hydrogels using imidazolidinyl urea as hydrogen bonding reinforced factor, J. Mater. Chem. B, 2020, 8, 3058-3063.

2019年
39. Tan, J., Lei, H., Liaw, D., Chen, X., Ma, L., Cui, C., Zhong, Q., Cheng, Y.*, Zhang. Y.*, Catalyst‐Free One‐Step Preparation of Self‐Crosslinked pH‐Responsive Vesicles. Macromol. Rapid Commun. 2019, 1900149
38. Wang, C., Feng, N., Chang, F., Wang, J., Yuan, B., Cheng, Y.*, Liu, Y.*, Yu, J., Zou, J.*, Ding, J.*, Chen, X., Injectable Cholesterol-Enhanced Stereocomplex Polylactide Thermogel Loading Chondrocytes for Optimized Cartilage Regeneration. Adv. Healthcare Mater. 2019, 1900312
37. Lei, H., Wang, S., Liaw, D., Cheng, Y., Yang, X., Tan, J., Chen, X., Gu, J.*, Zhang, Y.*, Tunable and Processable Shape-Memory Materials Based on Solvent-Free, Catalyst-Free Polycondensation between Formaldehyde and Diamine at Room Temperature. ACS Macro Lett. 2019, 85, 582-587
36. Peeler, D., Thai, S., Cheng, Y., Horner, P., Sellers, D.*, Pun, S. H.*, pH-sensitive polymer micelles provide selective and potentiated lytic capacity to venom peptides for effective intracellular delivery. Biomaterials 2019, 192, 235–244.
35. Ma, L., Cheng, Y. (co-first author), Liaw, D., Lei, H., Tan, J., Cui, C., Tong, H., Zhang. Y.*, Versatile preparation of vesicle from amphiphilic bottlebrush block copolymers.
34. Olden, B.R., Cheng, E., Cheng, Y., Pun, S. H.*, Identifying key barriers in cationic polymer gene delivery to human T cells., Biomater. Sci., 2019, 7, 789-797.

2018年
33. Cheng, Y., He, C.*, Ren, K., Rong, Y., Xiao, C., Ding, J., Zhuang, X., Chen, X.*, Injectable Enzymatically Cross‐linked Hydrogels with Light‐Controlled Degradation Profile. Macromol. Rapid Commun. 2018, 39, 1800272
32. Cheng, Y., Liu, G., Jain, R., Pippin, J., Shankland, S., Pun, S. H.*, Boronic acid copolymers for direct loading and acid-triggered release of Bis-T-23 in cultured podocytes. ACS Biomater. Sci. Eng. 2018, 4, 3968−3973
31. Olden, B.R.; Cheng, Y. (co-first author); Yu, J. L.; Pun, S. H.*, Cationic polymers for non-viral gene delivery to human T cells. J Control Release 2018, DOI:10.1016/j.jconrel.2018.02.043
30. Liu, H., Cheng, Y. (co-first author), Chen, J., Chang, F., Wang, J., Ding, J.*, Chen, X., Component effect of stem cell-loaded thermosensitive polypeptide hydrogels on cartilage repair. Acta Biomaterialia 2018, 73, 103–111.
29. Liu, G., Prossnitz, A., Eng, D., Cheng, Y., Subrahmanyam, N., Pippin, J., Lamm, R., Ngambenjawong, C., Ghandehari, H., Shankland, S., Pun, S. H.*, Glomerular disease augments kidney accumulation of synthetic anionic polymers. Biomaterials, 2018, 178, 317-325.
28. Feldmann, D. P., Cheng, Y., Kandil, R., Xie, Y., Mohammadi, M., Harz, H., Sharma, A., Peeler, D. J., Moszczynska, A., Leonhardt, H., Pun, S. H., Merkel, O. M.* In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells. J Control Release 2018, DOI: 10.1016/j.jconrel.2018.02.017.
27. Yen, A., Cheng, Y., Sylvestre, M., Gustafson, H., Puri, S., Pun, S. H.*, Serum Nuclease Susceptibility of mRNA Cargo in Condensed Polyplexes. Mol. Pharmaceutics, 2018, 156, 2268-2276.
26. Wang, C.E., Yumul, R.C., Lin, J., Cheng, Y., Lieber, A., Pun, S. H.*, Junction opener protein increases nanoparticle accumulation in solid tumors. J Control Release 2018, 272, 9-16.
25. Yang, X., Shen, S., Guo, L., Tan, J., Lei, H., Wu, J., Zhao, L., Xiong, T., Wu, Y., Cheng, Y., Zhang, Y.*, An Enzyme‐Responsive “Turn‐on” Fluorescence Polymeric Superamphiphile as a Potential Visualizable Phosphate Prodrug Delivery Vehicle. Macromol. Biosci. 2018, 18, 1800045.

2017年
24. Cheng, Y.; Sellers, D. L.; Tan, J. K. Y.; Peeler, D. J.; Horner, P. J.*; Pun, S. H.*, Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers. Biomaterials 2017, 127, 89-96.
23. Zhao, T.; Sellers, D. L.; Cheng, Y.; Horner, P. J.; Pun, S. H.*, Tunable, Injectable Hydrogels Based on Peptide-Cross-Linked, Cyclized Polymer Nanoparticles for Neural Progenitor Cell Delivery. Biomacromolecules 2017, 18, (9), 2723-2731.
22. Zheng, Y.; Cheng, Y.; Chen, J.; Ding, J.*; Li, M.; Li, C.; Wang, J.*; Chen, X., Injectable Hydrogel-Microsphere Construct with Sequential Degradation for Locally Synergistic Chemotherapy. Acs Appl Mater Inter 2017, 9, (4), 3487-3496.

2016年
21. Cheng, Y.; Yumul, R. C.; Pun, S. H.*, Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery. Angewandte Chemie International Edition 2016, 55, (39), 12013-12017.
20. Cheng, Y.; Wei, H.; Tan, J. K. Y.; Peeler, D. J.; Maris, D. O.; Sellers, D. L.; Horner, P. J.*; Pun, S. H.*, Nano-Sized Sunflower Polycations As Effective Gene Transfer Vehicles. Small 2016, 12, (20), 2750-2758.
19. Cheng, Y.*, Poly(ethylene glycol)-polypeptide Copolymer Micelles for Therapeutic Agent Delivery. Curr Pharm Biotechno 2016, 17, (3), 212-226.
18. Ding, J.; Cheng, Y.; Li, M.; Gref, R.; Chen, X., Smart Polymeric Nanocarriers. J Nanomater 2016.
17. Ma, H.; Jiang, W.; Ding, J.; Li, M.; Cheng, Y.*; Sun, S.; Fu, C.; Liu, Y., Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies. J Nanomater 2016.

2015年
16. Ma, H.; He, C.*; Cheng, Y.; Yang, Z.; Zang, J.; Liu, J.; Chen, X., Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment. Acs Appl Mater Inter 2015, 7, (49), 27040-27048.

2014年
15. Ma, H.; He, C.*; Cheng, Y.; Li, D.; Gong, Y.; Liu, J.*; Tian, H.*; Chen, X., PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatment. Biomaterials 2014, 35, (30), 8723-8734.
14. Cui, H.; Liu, Y.; Cheng, Y.; Zhang, Z.; Zhang, P.; Chen, X.*; Wei, Y.*, In Vitro Study of Electroactive Tetraaniline-Containing Thermosensitive Hydrogels for Cardiac Tissue Engineering. Biomacromolecules 2014, 15, (4), 1115-1123.
13. Xiao, C.; Cheng, Y.; Zhang, Y.; Ding, J.; He, C.; Zhuang, X.; Chen, X.*, Side Chain Impacts on pH- and Thermo- Responsiveness of Tertiary Amine Functionalized Polypeptides. J Polym Sci Pol Chem 2014, 52, (5), 671-679.
12. Ren, K.; He, C.; Cheng, Y.; Li, G.*; Chen, X., Injectable enzymatically crosslinked hydrogels based on a poly(l-glutamic acid) graft copolymer. Polymer Chemistry 2014, 5, (17), 5069-5076.

2013年
11. Cheng, Y.; He, C.; Ding, J.; Xiao, C.; Zhuang, X.; Chen, X.*, Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs. Biomaterials 2013, 34, (38), 10338-10347.
10. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Cui, H.; Zhuang, X.; Chen, X.*, Versatile Biofunctionalization of Polypeptide-Based Thermosensitive Hydrogels via Click Chemistry. Biomacromolecules 2013, 14, (2), 468-475.
9. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Ren, K.; Yu, S.; Zhuang, X.; Chen, X.*, Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry. Polymer Chemistry 2013, 4, (13), 3851-3858.
8. Ren, K.; Cheng, Y.; He, C.*; Xiao, C.; Li, G.*; Chen, X., The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers. Polymer 2013, 54, (9), 2466-2472.
7. Yu, S.; He, C.*; Ding, J.; Cheng, Y.; Song, W.; Zhuang, X.; Chen, X., pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery. Soft Matter 2013, 9, (9), 2637-2645.
6. Ding, J.; Xiao, C.; Li, Y.; Cheng, Y.; Wang, N.; He, C.; Zhuang, X.*; Zhu, X.*; Chen, X.*, Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions. J Control Release 2013, 169, (3), 193-203.

2012年
5. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Zhuang, X.; Huang, Y.; Chen, X.*, Decisive Role of Hydrophobic Side Groups of Polypeptides in Thermosensitive Gelation. Biomacromolecules 2012, 13, (7), 2053-2059.

2011年
4. Cheng, Y.; He, C. L.; Xiao, C. S.; Ding, J. X.; Zhuang, X. L.; Chen, X. S.*, Versatile synthesis of temperature-sensitive polypeptides by click grafting of oligo(ethylene glycol). Polymer Chemistry 2011, 2, (11), 2627-2634.
3. Ding, J.; Xiao, C.; Zhao, L.; Cheng, Y.; Ma, L.; Tang, Z.; Zhuang, X.; Chen, X.*, Poly(L-glutamic acid) Grafted with Oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal Phase Transition, Secondary Structure, and Self-Assembly. J Polym Sci Pol Chem 2011, 49, (12), 2665-2676.
2. Ding, J.; Zhuang, X.; Xiao, C.; Cheng, Y.; Zhao, L.; He, C.; Tang, Z.; Chen, X.*, Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery. Journal of Materials Chemistry 2011, 21, (30), 11383-11391.

2008年
1. Yan, Q.; Su, W.; Cheng, Y.; Luo, Y.; Zhang, Q.*, Luminescence and structure of Eu(DBM)(3)Phen-doped vesicles composed of amphiphilic PNIPAM-b-PAzoM. J Photoch Photobio A 2008, 200, (2-3), 101-105.

专利：

1. Yilong Cheng, Suzie Pun. Membrane-lytic block copolymers, US 62/371,163/, PCT/US2017/045566.

2. Suzie Pun, Yilong Cheng，Brynn Olden Polymers for T-cell transfection, US 62/476,003.

3.贺超良，成一龙，肖春生，丁建勋，任凯旋，庄秀丽，陈学思。一种嵌段共聚物、其制备方法及温度敏感型水凝胶。已授权，权利转移。专利号：201110359738。技术联系人

4.贺超良，成一龙，庄秀丽，肖春生，丁建勋，陈学思。 聚（γ-丙炔基-L-谷氨酸酯）嵌段共聚物、其制备方法及水凝胶。 已授权，权利转移。专利号：201110023965。技术联系人

5.贺超良，成一龙，庄秀丽，陈学思。聚氨基酸嵌段共聚物、其制备方法及温度敏感型水凝胶。授权公告号：102977362B。技术联系人

6.贺超良，成一龙，于双江，任凯旋，庄秀丽，陈学思。还原敏感型聚氨基酸纳米水凝胶及其制备方法。授权公告号：103224702B。技术联系人

7.陈学思，丁建勋，成一龙，庄秀丽。一种聚醚均聚物及其制备方法。授权公告号： 102838742B。

8.贺超良，任凯旋，成一龙，李杲，陈学思。聚氨基酸接枝共聚物及其制备方法、可注射性水凝胶。授权公告号：103524748B。

9.贺超良，任凯旋，成一龙，肖春生，李杲，陈学思。一种类糖肽及其制备方法、可注射性水凝胶。授权公告号：103936981B。

10.贺超良，于双江，成一龙，肖春生，丁建勋，庄秀丽，陈学思。含有二硫键和三级胺基团的聚氨酯嵌段共聚物及其制备方法。已授权，权利转移。  专利号：201210032905。

11.贺超良，徐清华，成一龙，肖春生，于双江，陈学思。聚(ε-甲基丙烯酰基-L-赖氨酸)均聚物、嵌段共聚物及功能化聚合物。授权公告号：103524728B。

12.庄秀丽，丁建勋，肖春生，成一龙，赵丽，汤朝晖，陈学思。聚（L-谷氨酸）均聚物、无规共聚物、接枝共聚物及其制备方法。已授权，权利转移。  专利号：201010563665。