华东师范大学化学与分子工程学院仇文卫

erdingxi

仇文卫
副教授教师
化学与分子工程学院
上海分子治疗与新药创制工程中心
联系电话： 021-54340103办公时间： 8:30am-6:00pm
传 真： 021-54340103主页网址：
办公地点： 华东师大化学系（闵行）525室电子邮箱： wwqiu@chem.ecnu.edu.cn
通讯地址： 华东师大化学系（闵行）525室
研究方向
1.药物发现；2.药物分子作用机制研究(小分子探针的设计、合成及其应用)；3.甾体药物绿色制造新工艺研究


工作经历：
2009.12-今：华东师范大学化学系副教授
2010.10-2011.10：哈佛大学访问学者（Professor E. J. Corey）
2006.09-2009.12：华东师范大学化学系讲师


学习经历：
2003.09-2006.07： 中国科学院上海药物研究所 理学博士
2000.09-2003.07：华东师范大学 理学硕士
1993.09-1997.07：常州大学 工学学士


学术成果
发表文章及专利：
41. Jinhua Wang, Yajing Xing, Yingying Wang, Yundong He, Liting Wang, Shihong Peng, Lianfang Yang, Jiuqing Xie, Xiaotao Li, Wenwei Qiu*, Zhengfang Yi1* and Mingyao Liu*. A novel BMI-1 inhibitor QW24 for the treatment of stem-likecolorectalcancer. J. Exp. Clin. Cancer Res. 2019, 38, 422.
40. Huiqing Chen, Yajing Xing, Jia Xie, Jiuqing Xie, Dong Xing,  Jie Tang, Fan Yang, Zhengfang Yi* and Wen-Wei Qiu*. Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potential antiproliferative agents for castration-resistant prostate cancer. RSC Advances 2019, 9, 33794–33799.
39. Zhen Chen, TuoShao, Wei Gao,  Hualong Fu,  ThomasLee Collier, Jian Rong, Xiaoyun Deng, Qingzhen Yu, Xiaofei Zhang, April T. Davenport, James B. Daunais, Hsiao-Ying Wey, Yihan Shao, Lee Josephson, Wen-Wei Qiu*, and StevenLiang*. Synthesis and Preliminary Evaluation of [11C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2(LRRK2) in Parkinson’s Disease. ChemMedChem 2019, 14, 1580-1585.
38. Jie Bai, Jia Xie, Yajing Xing, Li-Ting Wang, Jiuqing Xie, Fan Yang, Ting Liu, MingyaoLiu, Jie Tang, Zhengfang Yi, Wen-Wei Qiu*, Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oralanti-late-onset hypogonadism agents,  Eur. J. Med. Chem. 2019, 176, 21-40.
37. Jie Bai, Jia Xie, Li-Ting Wang, Yajing Xing, Qian-Ru Jiang, Fan Yang, Jie Tang, Zhengfang Yi*, Wen-Wei Qiu*. Discoveryof methylpyrimidine ring-fused diterpenoid analogs as a novel testosterone synthesis promoter. RSC Advances 2019, 9, 9709–9717.
36. Huiqing Chen, Jia Xie, Dong Xing, Jinping Wang, Jie Tang, Zhengfang Yi, Fei Xia, Wen-Wei Qiu*, Fan Yang*, Diastereoselective synthesis of 3,3-disubstituted-3-nitro-4-chromanone derivatives as potential antitumor agents. Org. Biomol. Chem. 2019, 17, 1062-1066.
35. Shi-You Jiang, Hui Li, Jing-Jie Tang, Jie Wang,Jie Luo, Bing Liu, Jin-Kai Wang, Xiong-Jie Shi,Hai-Wei Cui, Jie Tang, Fan Yang,Wei Qi, Wen-Wei Qiu*, Bao-Liang Song*. Discovery of a potent HMG-CoA reductase degrader that eliminatesstatin-induced reductase accumulation and lowers cholesterol. Nat. Commun. 2018, 9, 5138.
34. Xiao-Long He, Li-Ting Wang, Xiang-Zhong Gu,Jie-Xin Xiao, Wen-Wei Qiu*. A facilesynthesis of ursodeoxycholic acid and obeticholic acid from cholic Acid, Steroids 2018, 140, 173-178.
33. Lian-Fang Yang, Yajing Xing, Jie-Xin Xiao, JiaXie, Wei Gao, Jiuqing Xie, Li-Ting Wang, Jinhua Wang, Mingyao Liu, Zhengfang Yi*, Wen-WeiQiu*. Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-MediatedAntitumor Agents. ACS Med. Chem. Lett. 2018, 9, 1105-1110.
32. Xiao-Long He, Yajing Xing, Xiang-Zhong Gu, Jie-Xin Xiao, Ying-Ying Wang, Zhengfang Yi, Wen-Wei Qiu*. The synthesis and antitumor activity of lithocholic acid and its derivatives. Steroids 2017, 125, 54-60.
31. Xu Xiao, Jing-Jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-Ping Qiu, Yue Xiong, Lian-Fang Yang, Hai-Wei Cui, Xiao-Long He, Lei Yin, Wei Qi, Catherine C.L. Wong, Yun Zhao, Bo-Liang Li, Wen-Wei Qiu*, Bao-Liang Song*. Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling. Mol. Cell 2017, 66, 154-162.
30. Gao Wei, Yalan Wu, Xiao-Long He, Ting Liu, Mingyao Liu, Jian Luo*, Wen-Wei Qiu*. Synthesis of heterocyclic ring-fused tricyclic diterpene analogs as novel inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur. J. Med. Chem. 2017, 131, 48-67.
29. Ying-Ying Wang, Yuan He, Lian-Fang Yang, Shi-Hong Peng, Xiao-Long He,Jin-Hua Wang, Fang Lv, Yun Hao, Ming-Yao Liu, Zhengfang Yi*, Wen-Wei Qiu*. Synthesis of novel diterpenoidanalogs with in-vivo antitumoractivity. Eur. J. Med. Chem. 2016, 120, 13-25.
28. Hai-Wei Cui, Shihong Peng, Xiang-Zhong Gu, Huang Chen, Yuan He, Wei Gao , Fang Lv,Jin-Hua Wang, Yan Wang, Jia Xie, Ming- Yao Liu, Zhengfang Yi*, Wen-Wei Qiu*. Synthesisand biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosteronederivatives as antitumor agents. Eur. J. Med. Chem. 2016, 111, 126-137.
27. Ying-Ying Wang, Yuan-Xue Gao, Wei Gao, Yuan Xu, Ya-Zhou Xu, Yun-Jie Wang, Sai Chang, Li-Gang Yu, Lu-Yong Zhang, Hong Liao, Lian-Fang Yang, Tao Pang*, Wen-Wei Qiu*. Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury. Eur. J. Med. Chem. 2015, 103, 396-408.
26. Hai-Wei Cui,  Yuan He, Jinhua Wang, Wei Gao, Ting Liu, Min Qin, Xue Wang, Cheng Gao, Yan Wang, Ming-Yao Liu, Zhengfang Yi *, Wen-Wei Qiu*. Synthesis of heterocycle-modified betulinic acid derivatives as antitumor agents. Eur. J. Med. Chem. 2015, 95, 240-248.
25.  Li-Gang Yu, Teng-Feng Ni, Wei Gao, Yuan He, Ying-Ying Wang, Hai-Wei Cui, Cai-Guang Yang, Wen-Wei  Qiu*. The synthesis and antibacterial activity of pyrazole-fused tricyclic diterpene derivatives. Eur. J. Med. Chem. 2015, 90, 10-20.
24.  Gao Cheng, Dai Fu-Jun, Cui Hai-Wei, Peng Shi-Hong, He Yuan, Wang Xue, Yi Zheng-Fang*, Qiu Wen-Wei*. Synthesis of Novel Heterocyclic Ring-Fused 18β-Glycyrrhetinic Acid Derivatives with Antitumor and Antimetastatic Activity. Chem. Biol. Drug. Des.2014, 84, 223-233.
23.  Jun Xu‚ Zhenxi Li‚ Jian Luo‚ Fan Yang‚ Ting Liu‚ Mingyao Liu‚* Wen-Wei Qiu‚* and Jie Tang*. Synthesis and Biological Evaluation of Heterocyclic Ring-fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption. J. Med. Chem. 2012‚ 55‚ 3122-3134. (Highlighted by "SicBX")
22.   Hui Li‚ Hui Zou‚ Lixin Gao‚ Ting Liu‚ Fan Yang‚ Jingya Li‚ Jia Li‚* Wen-Wei Qiu‚* and Jie Tang. Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B. Heterocycles2012‚ 85‚ 1117-1139.
21.   Hui Li,  Jin-Ping Wang,  Fan Yang, Ting Liu,  Wen-Wei Qiu, Jing-Ya Li, Jia Li,*  Jie Tang. Design, synthesis and biological activity evaluation of 2-mercapto-4(3H)-quinazolinone derivatives as novel inhibitors of protein tyrosine phosphatase 1 B. Heterocycles2012‚ 85‚ 1897-1911.
20.   Wu X‚ Li Z‚ Yang Z‚ Zheng C‚ Chen Y‚ Ye X‚ Lian X‚ Qiu Wen-Wei‚ Yang F‚ Tang J‚ Xiao J‚ Liu M‚ Luo J. CADPE suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of MAPKs/AP-1 and Ca2+-NFAT signaling pathways. J. Bone Miner. Res. 2012, 27, 1298-1308.
19.   Jing-jie Tang‚ Jia-gui Li‚ Wei Qi‚ Wen-wei Qiu‚ Pei-shan Li‚ Bo-liang Li‚ and Bao-Liang Song. Inhibition of SREBP by a small molecule‚ betulin‚ improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metab. 2011‚ 13‚ 44-56.
18.   Wen-wei Qiu‚ Karavadhi Surendra‚ Liang Yin‚ and E. J. Corey‚ Selective formation of six-membered oxa- and carbocycles by the In(III)-activated ring closure of acetylenic substrates. Org. Lett. 2011‚ 13‚ 5893-5895.
17.   Karavadhi Surendra‚ Wen-wei Qiu‚ and E. J. Corey. A powerful new construction of complex chiral polycycles by an indium(III)-catalyzed cationic cascade. J. Am. Chem. Soc. 2011‚ 133‚ 9724-9726.
16.   Chun Li‚ Wen-wei Qiu‚ Zhengfeng Yang‚ Jian Luo‚ Fan Yang*‚ Ming-yao Liu‚ Juan Xie and Jie Tang*. Steroslective synthesis of some methyl-substituted steroid hormones and their in vitro cytotoxic activity against human gastric cancer cell line MGC-803. Steroids‚ 2010‚ 75‚ 859-869.
15.   Cheng-hai Li‚ Zheng-feng Yang‚ Zhen-xi Li‚ Yu Ma‚ Li-peng Zhang‚ Chun-bing Zheng‚ Wen-wei Qiu‚ Xian Wu‚ Xiu Wang‚ Hui Li‚ Jie Tang‚ Min Qian‚ Da-li Li1‚ Ping Wang‚ Jian Luo‚‚ Ming-yao Liu. Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways. J. Bone. Miner. Res. 2011‚ 26‚ 644-656.
14.   Cheng-hai Li‚ Zheng-feng Yang‚ Chun-yan Zhai‚ Wen-wei Qiu‚ Dali Li‚ Zheng-fang Yi‚ Lei Wang‚ Jie Tang‚ Min Qian‚ Jian Luo‚ and Ming-yao Liu. Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway. Mol. Cancer. 2010‚ 9(73), 1-13.
13.  Wen-wei Qiu‚ Qiang Shen‚ Fan Yang‚ Bo Wang‚ Hui Zou‚ Jing-ya Li‚ Jia Li*‚ Jie Tang*. Synthesis and biological evaluation of heterocyclic ring-  substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. Bioorg. Med. Chem. Lett. 2009‚ 19‚ 6618-6622.
12.  Wen-wei Qiu‚ Linmei He‚ Qi Chen‚ Wanrong Luo‚ Zhichao Yu‚ Fan Yang*‚ Jie Tang*. Imidazolium-modified poly(L-leucine) catalyst: an efficient and recoverable catalyst for Juliá–Colonna reactions. Tetrahedron Lett. 2009‚ 50‚ 5225-5227.
11.  Wen-wei Qiu‚ Jie Xu‚ Xin Li‚ Li Zhong‚ Jing-ya Li‚ Jia Li‚ Fa-jun Nan. Design and synthesis of matrix metalloprotease photoaffinity trimodular probes. Chin. J. Chem. 2009‚ 27‚ 825-833.
10. Bo Wang‚ Fan Yang‚ Yifan Shan‚ Wen-wei Qiu *‚ Jie Tang *.Highly efficient synthesis of capsaicin analogues by condensation of vanillylamine and acyl chlorides in a biphase H2O/CHCl3 system. Tetrahedron2009‚ 65‚ 5409-5412.
9.  Chun Shen‚ Wen-wei Qiu* Jie Tang. Enantioselective cyano-ethoxycarbonylation of aldehydes catalyzed by bifunctional salen-Ti complex. Chin. J. Org. Chem. 2009‚ 29‚ 426-431.
8.  Yong-hua Gong‚ Wen-wei Qiu‚ Fan Yang‚ Pierre Audebert‚ Gilles Clavier‚ Fabien Miomander‚ Jie Tang*. Pyridinium conjugated ferrocenes with thien and bithien bridges: synthesis and electrochemical properties. Chin. J. Chem.2009‚27‚ 1515-1522.
7.  Xiu-ling Xu‚ Wen-wei Qiu‚ Qing Zhou‚ Pierre Audebert‚ Jie Tang*‚ Fan Yang*‚ Zhen-rong Sun*‚ Nonlinear Optical Absorption Properties of Two ultisubstituted p-Dimethylaminophenyl- ethenyl Pyridiniums. J. Phy. Chem. B2008‚ 112‚ 4913-4917.
6.  Wen-wei Qiu‚ Jie Xu‚ Jing-Ya Li‚ Jia Li‚ and Fa-Jun Nan. Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes. ChemBioChem. 2007‚ 8‚ 1351-1358.
5.  Fan Yang‚ Xiu-Ling Xu‚ Yong-Hua Gong‚ Wen-Wei Qiu‚ Zhen-Rong Sun‚ Jin-Wei Zhou‚ Pierre Audebert and Jie Tang. Synthesis and nonlinear optical absorption properties of two new conjugated ferrocene-bridge-pyridinium compounds. Tetrahedron2007‚ 63‚ 9188-9194.
4.  Wen-wei Qiu‚ Jie Xu‚ Da-Zhi Liu‚ Jing-Ya Li‚ Yang Ye‚ Xing-Zu Zhu‚ Jia Li and Fa-Jun Nan. Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin. Bioorg. Med. Chem. Lett. 2006‚ 16‚ 3306-3309.
3. 徐军‚ 王晋萍‚ 钱辰旭‚ 仇文卫*‚ 杨帆‚ 汤杰. 白桦脂酸的研究进展. 生命科学.  2011‚ 23‚ 503-510.
2. 仇文卫‚ 汤杰. 化学小分子探针在药物发现中的应用. 化学教学. 2009‚ 9‚ 1-4.
1. 王博‚ 仇文卫*‚ 喻艳华‚ 杨帆‚ 汤杰. 山楂酸的研究进展. 生命科学. 2009‚ 21‚ 264-269.

中国发明专利(已授权):
1.中国发明专利：抗肿瘤的MA-TNFa药物组合物及其应用，专利号：200910195266.5, 专利授权日期：2013年2月20日，发明人: 刘明耀, 罗剑, 李成海, 杨正峰, 仇文卫, 汤杰
2.中国发明专利：用于制备抗骨质疏松药的桦木酮酸衍生物及其制备和应用，专利号：201110059600.1，专利授权日期：2013年3月12日，发明人：杨帆、刘明耀、汤杰、罗剑、仇文卫、徐军、李珍惜
3.中国发明专利：喹唑啉酮衍生物及其制备和应用，专利号：201010126943.0，授权公告日：2011年12月28日，发明人：杨帆、汤杰、仇文卫、王利华、赵丽华、穆秋超
4.中国发明专利：季铵盐多聚-L-亮氨酸催化剂及其制备和应用，专利号：200710036543.9，授权公告日：2012年2月8日，发明人：汤杰、杨帆、仇文卫、何林美、王博、周卿
5.中国发明专利：一种通过界面反应制备香兰酰胺类化合物的方法, 专利号：200910047630.3，授权公告日：2012年5月23日，发明人：杨帆、单益凡、汤杰、王博、孙国平、仇文卫
6.中国发明专利：山楂酸衍生物及其制备和应用, 专利号：200910055852.X, 授权公告日：2012年7月4日，发明人：汤杰、李佳、王博、仇文卫、沈强、杨帆、张薇、邹慧
7.中国发明专利：一种桦木酮酸的制备方法, 专利号：201010100993.1，授权公告日：2012年7月4日, 发明人：汤杰、仇文卫、杨帆、刘兵、徐军、龚雪萍
8.中国发明专利：桦木酮酸衍生物及其制备和应用，专利号：201110059622.8，授权公告日：2012年11月14日，发明人：汤杰、刘明耀、仇文卫、罗剑、杨帆、徐军、李珍惜
9.中国发明专利：抑制破骨细胞分化的桦木酮酸衍生物及其制备和应用，专利号：201110059609.2，专利授权日期：2012年11月14日，发明人：仇文卫、罗剑、汤杰、刘明耀、杨帆、徐军、李珍惜
10.中国发明专利：一种可循环叔胺环钯化合物催化体系及其应用,专利号：200810036212.X，授权公告日：2011.06.01，发明人：汤杰、沈丹平、张兆国、喻艳华、李慧、仇文卫、杨帆
11.中国发明专利：5a-雄甾-7-甲基-3-羟基-17-酮的制备和应用,专利号：ZL 200710039805.7，授权公告日：2009年4月15日，发明人：杨帆、郑从燊、汤杰、仇文卫


主持科研项目：
1.  国家自然科学基金重大研究计划子课题：蛋白质胆固醇动态修饰的调控机制、化学干预和功能研究，（项目编号：14303-41211-18025），执行年限2018.1-2021.12
2.  上海市自然科学基金：抗结肠癌先导化合物的发现、结构优化及其抗肿瘤活性研究。（项目号：18ZR1411200），执行年限：2018.7-2021.6
3.  国家自然科学青年基金：新型PTP1B抑制剂-山楂酸衍生物的分子设计‚合成与活性研究。（项目号：20802020）执行年限：2009.1-2011.12
4. 教育部博士点新教师基金：新型蛋白酪氨酸酯酶IB抑制剂－山楂酸衍生物的构效关系研究。（项目号：200802691039）执行年限：2009.1-2011.12
5. 上海市自然科学基金：甾类衍生物的设计合成及其促羟甲基戊二酰辅酶A还原酶的泛素化降解活性研究。（项目号：12ZR1408500）执行年限：2012.7-2015.6
6. 华东师范大学创新基金面上项目：水溶性白桦脂酸衍生物的设计、合成及其对破骨细胞生成抑制的活性研究。（项目号：78260001）执行年限：2013.1-2014.12