中南大学化学化工学院制药工程系阳华

dansu

阳华（制药工程系主任）
学 位：博士学位
职 称：教授
学 科：化学工程与技术
单 位：中南大学
主要任职：制药工程系主任
所在学院：化学化工学院
办公地点：新校区化学楼346
电子信箱：hyangchem@csu.edu.cn
联系方式：18684972575
毕业院校：West Virginia University
教育经历
1991.9-1995.6四川大学 | 精细化工 学士学位 | 大学本科毕业
1995.9-1998.6四川大学 | 有机化学 硕士学位 | 硕士研究生毕业
2001.9-2006.5West Virginia University | 有机化学
博士学位 | 博士研究生毕业
工作经历
2006.6-2009.6  Oregon State University  |  博士后
2009.6-2011.6  Oregon State University  |  副研究员
2011.9-至今  化学化工学院 |  中南大学  |  教授
个人简介
阳华，博士，中南大学“升华学者”特聘教授，博士生导师。阳华教授长期以来致力于有机合成，不对称催化，及手性药物分子的全合成研究工作，主持国家自然科学基金，湖南省科技厅重点项目，参与多项美国NSF以及NIH的基金研究工作。研发出具有优异性能的有机催化剂-“Hua Cat”, 广泛应用在手性分子的不对称合成中，并申请国际专利，并已通过精细化学品公司-- Sigma-Aldrich公司商品化，在全球销售。近年来在J. Am. Chem. Soc., Org. Lett., Chem. Comm., J. Org. Chem. 等世界一流期刊上发表学术论文近50篇。
研究概况
阳华教授课题组目前主要研究方向包括：有机小分子催化剂的设计、合成及其在不对称合成中的应用；光氧化还原催化与有机催化协同催化体系研究；不对称自催化体系等。目前共有课题组成员13人，已毕业9人。
论文成果
•        [1] Ji-Wei Ren, Jing Wang, Jun-An Xiao, Jun Li, Hao-Yue Xiang, Xiao-Qing Chen, Hua Yang.. L-Pyroglutamic Sulphonamide as Hydrogen-Bonding Organocatalyst: Enantioselective Diels–Alder Cyclization to Construct Carbazolespirooxindoles 2017, 82: 6441-6449   
•        [2] Y. L. Qian, P. J. Xia, J. Li, Q. L. Zhao, J. A. Xiao, H. Y. Xiang, and H. Yang. Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds 2017,     
•        [3] Chao-Ming Wang†, Peng-Ju Xia†, Jun-An Xiao, Jun Li, Hao-Yue Xiang*, Xiao-Qing Chen, and Hua Yang*. Photoredox-Catalyzed Reductive Dimerization of Isatins and Isatin-Derived Ketimines: Diastereoselective Construction of 3,3′-Disubstituted Bisoxindoles 2017, 82: 3895−3900   
•        [4] Shasha Wang, Junan Xiao, Jun Li, Haoyue Xiang, Chaoming Wang, Xiaoqing Chen,* Rich G. C. Discovery of temperature-dependent, autoinductive reversal of enantioselectivity: palladium-mediated [3+3]-annulation of 4-hydroxycoumarins Chem. Commun., 2017, 4441-4444   
•        [5] Xiang, H.; Zhao, Q.; Tang, Z.; Xiao, J.; Xia, P.; Wang, C.; Yang, C.; Chen, X.; Yang, H.. Visible-Light-Driven, Radical-Triggered Tandem Cyclization of o Hydroxyaryl Enaminones: Facile Access to 3 CF 2 /CF 3  Containing Chromones. Org. Lett., 2016,     
•        [6] Xiao, J. A.; Xia, P. J.; Zhang, X. Y.; Chen, X. Q.; Ou, G. C.; Yang, H.. Amide-assisted intramolecular [3+2] annulation of cyclopropane ring-opening: a facile and diastereoselective access to the tricyclic core of (±)-scandine. Chem. Commun., 2016, 52: 2177-2180   
•        [7] Wang, C. M.; Xiao, J. A.; Wang, J.; Wang, S. S.; Deng, Z. X.; Yang, H.. Organocatalytic Enantioselective Conjugate Addition of Azlactones to Enolizable Linear and Cyclic Enones. J. Org. Chem., 2016, 81: 8001-8008   
•        [8] Xiao, J. A.; Li, J.; Xia, P. J.; Zhou, Z. F.; Deng, Z. X.; Xiang, H. Y.; Chen, X. Q.; Yang, H.. Diastereoselective Intramolecular [3 + 2]-Annulation of Donor−Acceptor Cyclopropane with Imine-Assembling Hexahydropyrrolo[3,2-c]quinolinone Scaffolds. J. Org. Chem., 2016, 81: 11185-11194   
•        [9] Ren, J. W.; Zhou, Z. F.; Xiao, J. A.; Chen, X. C.; Yang, H.. Acid-Relayed Organocatalytic exo-Diels–Alder Cycloaddition of Cyclic Enones with 2-Vinyl-1H-indoles Eur. J. Org. Chem., 2016, 2016: 1264-1268   
•        [10] Xia, P. J.; Xiao, J. A.; Sun, Y. H.; Li, J.; Xiang, H. Y.; Chen, X. Q.; Yang, H.. Divergent Aerobic Oxidative Ring-Opening Cascades of Isatins with 1,2,3,4-Tetrahydroisoquinoline Eur. J. Org. Chem., 2016, 2016: 5096-5101   
•        [11] Xia, P. J.; Sun, Y. H.; Xiao, J. A.; Zhou, Z. F.; Wen, S. S.; Xiong, Y.; Ou, G. C.; Chen, X. Q.; Yan. Regioselectivity-Tunable Self-1,3-Dipolar [3+3] Cyclizations of Azomethine Ylides To Assemble Dispirooxindole-piperazines. J. Org. Chem., 2015, 80: 11573-11579   
•        [12] Wang, J.; Liu, Q.; Hao, Q.; Sun, Y. H.; Luo, Y. M.; Yang, H.. Enantioselective Aldol Reaction Between Isatins and Cyclohexanone Catalyzed by Amino Acid Sulphonamides. Chirality, 2015, 27: 314-319   
•        [13] Sun, Y. H.; Xiong, Y.; Peng, C. Q.; Li, W.; Xiao, J. A.; Yang, H.. Highly stereoselective construction of novel dispirooxindole–imidazolidines via self-1,3-dipolar cyclization of ketimines Org. Biomol. Chem., 2015, 13: 7907-7910   
•        [14] Liu, J.; Wen, S. S.; Wang, J.; Xiao, J. A.; Huang, S. R.; Yang, H.. Dually activated Michael-Michael-acetalization cascade: facile and highly diastereoselective construction of tetrahydro-6-hydroxyl-6H-benzo[c]chromen-9-one polycyclic scaffold Tetrahedron, 2015, 71: 4629-4634   
•        [15] Xiao, J. A.; Wang, C. M.; Wang, J.; Ou, G. C.; Zhang, X. Y.; Yang, H.. Highly stereoselective synthesis of novel spiroimidazolidinones directed by pyridine prolinamide Tetrahedron, 2015, 71: 805-812   
•        [16] Yang, H.; Carter, R. G.. Enantioselective Total Synthesis of Lycopodine. J. Am. Chem. Soc., 2008, 130: 9238-9239   
•        [17] Yang, H.; Carter, R. G.. Synthesis of All-Carbon, Quaternary Center-Containing Cyclohexenones through an Organocatalyzed, Multi-Component Coupling. Org. Lett., 2010, 12: 3108-3111   
•        [18] Yang, H.; Carter, R. G.. N-(p-dodecylphenylsulfonyl)- 2-Pyrrolidinecarboxamide: A Practical Proline Mimetic for Facilicating Enantioselective Aldol Reactions, Org. Lett., 2008, 10: 4649-4652   
•        [19] Yang, H.; Carter, R. G.. Development of an Enantioselective Route towards the Lycopodium Alkaloids: Total Synthesis of Lycopodine. J. Org. Chem., 2010, 75: 4929-4938   
•        [20] Yang, H.; Carter, R. G.. Enantioselective Mannich Reactionsusing the Practical Proline Mimetic N-(p-dodecylphenylsulfonyl)-2-Pyrrolidinecarboxamide. J. Org. Chem., 2009, 74: 2246-2249