中南大学化学化工学院应用化学系李娟

malingshu

李娟
副教授 、研究生导师
单位：化学化工学院
入职时间：2008年07月14日
学位：博士学位
专业：化学
毕业院校：复旦大学
电子邮件：juanli@csu.edu.cn
办公地点：中南大学新校区化学楼429
个人简历
李娟，女，副教授，博士。
1981年出生，湖南湘乡人。
1999-2003：本科毕业于湘潭大学化学专业，获学士学位。
2002-2005：获湘潭大学高分子化学与物理专业理学硕士学位，导师为黎华明教授，主要从事间规聚苯乙烯的改性研究。
2005-2008：毕业于复旦大学高分子化学与物理专业，获理学博士学位，导师为江明院士和姚萍教授，研究方向为大分子组装，主要从事天然高分子的组装及其生物医药应用研究。
2008.07至今：中南大学化学化工学院从事教学和科研工作。
2010.01-2010.12：作为兼聘人员于国家自然科学基金委化学部工作。
2011.12-2013.02：加拿大Laval大学从事博士后研究工作，导师为Muriel Subirade 教授。
    近年来在SCI源刊发表学术论文近30篇，申请专利10余项，第一发明人授权专利4项。
    目前主持自然科学基金面上项目2项。已承担完成1项国家自然科学基金青年项目，1项湖南省自然科学基金青年项目。2012年入选中南大学育英学者计划，2017年获中南大学创新驱动计划项目资助。
   
研究兴趣为分子组装、水凝胶以及生物医用纳米材料。
研究成果更新    http://www.researcherid.com/rid/G-2672-2013
研究方向
[1]   水凝胶
[2]   纳米生物医用材料
[3]   分子组装
科研项目
[1]多糖/短肽互穿网络水凝胶的可控制备及其口服药物控释应用
[2]多糖基长循环脂质体的构建与载体的多功能集成
[3]天然高分子材料的可控组装与功能化
[4]多糖脂质体作为多功能药物载体的研究
[5]新型长循环磁性脂质体的制备与药物控释研究
[6]多糖改性的载药明胶纳米粒子的研究
论文成果
•        [1] Juan Li, Huaming Li*. Functionalization of syndiotactic polystyrene with succinic anhydride in the presence of aluminum chloride [J]. European Polymer Journal, 2005, 41: 823-829
•        [2] Hongbiao Chen, Juan Li, Huaming Li*. Preparation and characterization of maleic anhydride modified syndiotactic polystyrene [J]. Iranian Polymer Journal, 2008, 17: 703-710
•        [3] Juan Li, Shaoyong Yu, Ping Yao*, Ming Jiang. Lysozyme-dextran core-shell nanogels prepared via a green process [J]. Langmuir, 2008, 24: 3486-3492
•        [4] Juan Li, Ping Yao*. Self-assembly of ibuprofen and bovine serum albumin-dextran conjugates leading to effective loading of the drug [J]. Langmuir, 2009, 25: 6385-6391
•        [5] Wei Deng, Juan Li, Ping Yao*, Fen He, Chong Huang. Green preparation process, characterization and antitumor effects of doxorubicin–BSA–dextran nanoparticles [J]. Macromolecular Bioscience, 2010, 10: 1224-1234
•        [6] Juan Li, Yu Zhou, Meng Li, Ning Xia, Qiyu Huang, Huy Do, You-Nian Liu*, Feimeng Zhou*. Carboxymethylated dextran-coated magnetic iron oxide nanoparticles for regenerable bioseparation [J]. Journal of Nanoscience and Nanotechnology, 2011, 11: 10187-10192
•        [7] Chuan-Wan Wei, Yong Peng, Lin Zhang, Qiyu Huang, Ming Cheng, You-Nian Liu*, Juan Li*. Synthesis and evaluation of ferrocenoyl pentapeptide (Fc-KLVFF) as an inhibitor of Alzheimer's Aβ1-42 fibril formation in vitro [J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21: 5818-5821
•        [8] Yong Peng, Chuan-Wan Wei, You-Nian Liu*, Juan Li*. Nafion coating the ferrocenylalkanethiol and encapsulated glucose oxidase electrode for amperometric glucose detection [J]. Analyst, 2011, 136: 4003-4007
•        [9] Shunhua Ning, Qiyu Huang, Xiaoyi Sun, Chunlei Li, Yi Zhang, Juan Li*, You-Nian Liu*. Carboxymethyl dextran-coated liposomes: Toward a robust drug delivery platform [J]. Soft Matter, 7: 9394-9401
•        [10] Shunhua Ning, Qiyu Huang, Juan Li*, Yi Zhang, You-Nian Liu*. Functionalized dextran-coated liposomes for doxorubicin loading [J]. Journal of Controlled Release, 2011, 152(e1): e49-e51
•        [11] Huihui Zhou, Xiaoyi Sun, Lili Zhang, Pei Zhang, Juan Li*, You-Nian Liu*. Fabrication of biopolymeric complex coacervation core micelles for efficient tea polyphenol delivery via a green process [J]. Langmuir, 28: 14553-14561
•        [12] Binbin Zhou, Juan Li, Bi-Jun Feng, Yang Ouyang, You-Nian Liu*, Feimeng Zhou*. Syntheses and in vitro antitumor activities of ferrocene-conjugated Arg-Gly-Asp peptides [J]. Journal of Inorganic Biochemistry, 2012, 116: 19-25
•        [13] 魏传晚, 李娟, 刘又年. 二茂铁修饰Aβ疏水段五肽的电化学性质及自组装研究 [J]. 无机化学学报, 2013, 29: 45-49
•        [14] Binbin Zhou, Chun-Lan Li, Yuan-Qiang Hao, Muya Chabu Johnny, You-Nian Liu*, Juan Li*. Ferrocene tripeptide Gly-Pro-Arg conjugates: synthesis and inhibitory effects on Alzheimer's Aβ1-42 fibrillogenesis and Aβ-induced cytotoxicity in vitro [J]. Bioorganic & Medicinal Chemistry, 2013, 21: 395-402
•        [15] Chunxiao Zhang, Xiaoyi Sun, Juan Li*, You-Nian Liu*. Synthesis of Ag nanoclusters by pH-dependent etching method in the aqueous solution [J]. Nanoscale, 2013, 6261-6264
•        [16] Liqiang Wang, Qiguang Zang, Wansong Chen, Yuanqiang Hao, You-Nian Liu*, Juan Li*. A ratiometric fluorescent probe with excited-state intramolecular proton transfer for benzoyl peroxide [J]. RSC Advances, 2013, 3: 8674-8676
•        [17] Wansong Chen, Weizhu Ou, Liqiang Wang, Yuanqiang Hao, Jiashun Cheng, Juan Li*, You-Nian Liu*. Synthesis and biological evaluation of hydroxylsubstituted Schiff-bases containing ferrocenyl moieties [J]. Dalton Transactions, 2013, 42: 15678-15686
•        [18] Yuanqiang Hao, Binbin Zhou, Fangbin Wang, Juan Li, Liu Deng*, You-Nian Liu*. Construction of highly ordered polyaniline nanowires and their applications in DNA sensing [J]. Biosensors and Bioelectronics, 2014, 52: 422-426
•        [19] Wansong Chen, Qiyu Huang, Weizhu Ou, Yuanqiang Hao, Liqiang Wang, Ke Zeng, Hongyan Guo, Juan Li*, et. Self-reporting Liposomes for Intracellular Drug Release [J]. Small, 2014, 10: 1261-1265
•        [20] Lili Zhang, Zeyou Qi, Qiyu Huang, Ke Zeng, Xiaoyi Sun, Juan Li*, You-Nian Liu*. Imprinted-like biopolymeric micelles as efficient nanovehicles for curcumin delivery [J]. Colloids and Surfaces B: Biointerfaces, 2014, 123: 15-22
专利成果
[1]疏水改性葡聚糖修饰的长循环脂质体及其制备方法
[2]一种稳定的多糖修饰明胶纳米粒子及其制备方法和应用
[3]一种两亲性羧甲基葡聚糖修饰的磁性脂质体及其制备和应用方法
[4]一种包封多酚类活性物质的纳米粒子及其制备方法
[5]一种明胶-多糖接枝物包覆多酚类物质的方法
[6]一种酸酐修饰与海藻酸包埋联用的固定化漆酶及其制备方法和应用
[7]基于海藻酸和短肽的互穿网络水凝胶及其制备方法