陕西师范大学化学化工学院分析化学张耀东

zhongyuzhong

张耀东
职  称：教授
毕业学校：西安交通大学
电  话：
电子邮箱：ydzhang@snnu.edu.cn
研究方向：生化分析与传感
个人简介
       2006获西安交通大学生命科学学院生物医学工程专业博士学位。2002年至2003年获德国学术交流中心（DAAD）生命科学特别项目奖学金资助（Sandwich scholarship），德国斯图加特大学（University of Stuttgart）技术生物化学研究所 (Institute of Technical Biochemistry)联合培养博士研究生。2008年至2009在德国斯图加特大学技术生物化学研究所从事博士后研究。1996年至今在陕西师范大学化学化工学院工作，主要研究方向为生化分析与传感，目前研究工作主要集中在（1）有机磷水解酶的分子设计、分子模拟及分析应用；（2）金属有机框架材料（MOFs）的设计、合成及分析应用。
   主持完成国家自然科学基金面上项目“基于分子印迹有机磷水解模拟酶的仿生传感器（NO.21275097）”和青年基金项目“基于酶学性能改良的乙酰胆碱酯酶微电极阵列有机磷生物传感器（NO.30600494）”。曾参与完成国家自然科学基金重大研究计划1项（NO.90607016），面上项目1项（NO.20175012）；陕西省自然科学基金2项（NO.98H03和99SM75）。在Analytical chemistry, Chemical Communications, ACS Applied Materials & Interfaces等期刊上发表论文30余篇。
代表性成果
[1]. Mengfan Xia, Caixia Zhuo, Xuejuan Ma, Xiaohong Zhang, Huaming Sun, Quanguo Zhai*, Yaodong Zhang*. Assembly of the active center of organophosphorus hydrolase in metal–organic frameworks via rational combination of functional ligands. Chemical Communications. 2017, 53, 11302-11305.
[2]. Xuejuan Ma, Lin Zhang, Mengfan Xia, Shuangqin Li, Xiaohong Zhang, Yaodong Zhang*. Mimicking the active sites of organophosphorus hydrolase on the backbone of graphene oxide to destroy nerve agent simulants. ACS Applied Materials & Interfaces. 2017, 9, 21089–21093.
[3]. Jingjing Feng, Caixia Zhuo, Xuejuan Ma, Shuangqin Li, Yaodong Zhang*. A peptide with a cysteine terminus:  probe for label-free fluorescent detection of thrombin activity. Analyst. 2016, 141（14）, 4481-7.
[4]. Shuangqin Li, Yuewei Fu, Xuejuan Ma, Yaodong Zhang*. Label-free fluorometric detection of chymotrypsin activity using graphene oxide/nucleic-acid-stabilized silver nanoclusters hybrid materials. Biosensors& Bioelectronics. 2016 , 88 :210-216.
[5]. KeKe Ma, Lu Lu, Zongli Qi, Jingjing Feng, Caixia Zhuo, Yaodong Zhang*. In situ induced metal-enhanced fluorescence: A new strategy for biosensing the total acetylcholinesterase activity in sub-microliter human whole blood.Biosensors& Bioelectronics. 2015, 68：648-653.
[6]. Lihui Wang, Keke Ma, Yaodong Zhang*. Label-free fluorometric detection of S1 nuclease activity by using polycytosine oligonucleotide-templated silver nanoclusters. Analytical Biochemistry. 2015, 468:34-38.
[7]. Lu Lu, Yunxia Qian, Lihui Wang, Keke Ma, Yaodong Zhang*. Metal-Enhanced Fluorescence-Based Core–shell Ag@SiO2 Nanoflares for Affinity Biosensing via Target-Induced Structure Switching of Aptamer. ACS Applied Materials & Interfaces. 2014, 6(3), 1944−1950.
[8]. Yunxia Qian, Yaodong Zhang*, Lu Lu, Yanan Cai. A label-free DNA-templated silver nanocluster probe for fluorescence on-off detection of endonuclease activity and inhibition. Biosensors & Bioelectronics. 2014, 51, 408–412.
[9]. Yaodong Zhang*, Yanan Cai, Zongli Qi, Lu Lu, Yunxia Qian. DNA-templated silver nanoclusters for fluorescence turn-on assay of acetylcholinesterase activity. Analytical chemistry. 2013, 85 (17), 8455–8461.
[10]. Yaodong Zhang*, Tingting Hei, Yanan Cai, Qunqun Gao, Qi Zhang. Affinity binding-guided fluorescent nanobiosensor for acetylcholinesterase inhibitors via distance modulation between the fluorophore and metallic nanoparticle. Analytical chemistry. 2012, 84 (6): 2830–2836.