陕西师范大学化学化工学院分析化学刘成辉

zhongyuzhong

刘成辉
职  称：教授（博士生导师）
毕业学校：清华大学（博士）
电  话：
电子邮箱：liuch@snnu.edu.cn
研究方向：生化分析及分子诊断
个人简介
     2009年7月于清华大学化学系获得理学博士学位。现为陕师大化学化工学院教授，分析化学和化学生物学专业博士生导师。2015年度“陕西省青年科技新星”；2016年获得国家基金委“优秀青年科学基金”资助；现担任Wiley出版社ChemistrySelect期刊编委。主要研究兴趣为：（1）生化分析与分子诊断；（2）功能材料表界面传感；（3）单分子与单细胞分析。先后主持国家自然科学基金等省部级以上项目9项。作为通讯作者或第一作者在Angew. Chem. Int. Ed., Chem. Sci., Anal. Chem., Chem. Commun.等发表论文40余篇，他引900余次。
    因科研工作需要，课题组常年招聘师资博士后，特别优秀者可直接申报副教授岗位，陕师大正处于快速发展时期，人才引进力度大，待遇优厚，具体情况可邮件联系。热忱欢迎从事生命分析化学、功能材料与器件、分子诊断、纳米生物技术、拉曼成像等相关领域的同仁加盟合作。
代表性成果
19. Wenjiao Fan, Yan Qi, Liying Qiu, Pan He, Chenghui Liu*, Zhengping Li. Click Chemical Ligation-Initiated On-Bead DNA Polymerization for the Sensitive Flow Cytometric Detection of 3′-Terminal 2′-OMethylated Plant MicroRNA. Anal. Chem., 2018, DOI: 10.1021/acs.analchem.8b00589.
18. Yueying Sun, Yuanyuan Sun, Weimin Tian, Chenghui Liu,* Kejian Gao, Zhengping Li.* A novel restriction endonuclease GlaI for rapid and highly sensitive detection of DNA methylation coupled with isothermal exponential amplification reaction. Chem. Sci., 2018, 9, 1344-1351.
17. Desheng Chen, Xiaobo Zhang, Liping Zhu, Chenghui Liu,* Zhengping Li.* Single Microbead-Anchored Fluorescent Immunoassay (SMFIA): A Facile and Versatile Platform Allowing Simultaneous Detection of Multiple Antigens. Chem. Asian J., 2017, 12, 2894-2898. (Featured as Front Cover)
16. Yuanyuan Sun, Hui Tian, Chenghui Liu,* Yueying Sun, Zhengping Li.* One-step detection of microRNA with high sensitivity and specificity via target-triggered loop-mediated isothermal amplification (TT-LAMP). Chem. Commun., 2017, 53, 11040-11043.
15. Liying Qiu, Yuecheng Zhang, Chenghui Liu,* Zhengping Li.* A Versatile Size-Coded Flow Cytometric Bead Assay for Simultaneous Detection of Multiple MicroRNAs Coupled with a Two-Step Cascading Signal Amplification. Chem. Commun., 2017, 53, 2926-2929.
14. Xiangdong Wang, Hui Wang, Chenghui Liu,* Honghong Wang, Zhengping Li.* A three-way junction structure-based isothermal exponential amplification strategy for sensitive detection of 3’-terminal 2’-O-methylated plant microRNA. Chem. Commun., 2017, 53, 1124-1127.
13. Hui Tian, Yuanyuan Sun, Chenghui Liu,* Xinrui Duan, Wei Tang, Zhengping Li.* Precise Quantitation of MicroRNA in a Single Cell with Droplet Digital PCR Based on Ligation Reaction. Anal. Chem., 2016, 88, 11384−11389.
12. Junting Li, Qi Zhao, Feng Shi, Chenghui Liu,* Yanli Tang.* NIR-Mediated Nanohybrids of Upconversion Nanophosphors and Fluorescent Conjugated Polymers for High-Efficiency Antibacterial Performance Based on Fluorescence Resonance Energy Transfer. Adv. Healthcare Mater., 2016, 5, 2967-2971. (Highlighted by MaterialsViewsChina)
11. Chao Jiang, Ya Li, Chenghui Liu,* Liying Qiu, Zhengping Li. A General and Versatile Fluorescence Turn-On Assay for Detecting the Activity of Protein Tyrosine Kinases Based on Phosphorylation-Inhibited Tyrosyl Oxidation. Chem. Commun., 2016, 52, 12570-12573. (Featured as Front Cover)
10. Honghong Wang, Hui Wang, Chenghui Liu,* Xinrui Duan, Zhengping Li.* Ultrasensitive Detection of Telomerase Activity in a Single Cell Using Stem-loop Primer-mediated Exponential Amplification (SPEA) with Near Zero Nonspecific Signal. Chem. Sci., 2016, 7, 4945-4950.
9. Xiaohui Lu, Peipei Wang, Yucong Wang,* Chenghui Liu,* Zhengping Li. A Versatile Dual-Emission Fluorescent Microhybrid Enabling Visual Detection of Glucose and Other Oxidases-Based Biocatalytic Systems. Adv. Mater. Technol., 2016, 1, 1600024. (Inside Front Cover, Highlighted by MaterialsViewsChina)
8. Xiaobo Zhang, Chenghui Liu,* Honghong Wang, Hui Wang, Zhengping Li.* Rare Earth Ion Mediated Fluorescence Accumulation on a Single Microbead: An Ultrasensitive Strategy for the Detection of Protein Kinase Activity at the Single-Cell Level. Angew. Chem. Int. Ed., 2015, 54, 15186-15190.
7. Xiaobo Zhang, Chenghui Liu,* Lingbo Sun, Xinrui Duan, Zhengping Li.* Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level. Chem. Sci., 2015, 6, 6213-6218. (Highlighted by ChemistryWorld and Chemical Science Blog, Hot Article)
6. Haoxian Zhou, Hui Wang, Chenghui Liu,* Honghong Wang, Xinrui Duan, Zhengping Li.* Ultrasensitive genotyping with target-specifically generated circular DNA templates and RNA FRET probes. Chem. Commun., 2015, 51, 11556-11559. (Featured as Front Cover, Hot Article of ChemComm)
5. Yuecheng Zhang, Chenghui Liu,* Sujuan Sun, Yanli Tang, Zhengping Li.* Phosphorylation-Induced Hybridization Chain Reaction on Beads: An Ultrasensitive Flow Cytometric Assay for the Detection of T4 Polynucleotide Kinase Activity. Chem. Commun., 2015, 51, 5832-5835. (Featured as Inside Front Cover)
4. Chenghui Liu,* Fangfang Wang, Yucong Wang, Zhengping Li.* A versatile fluorescence turn-on assay for highly sensitive detection of tyrosine phosphatase activity. Chem. Commun., 2014, 50, 13983-13986.
3. Pengpo Zhang, Jiangyan Zhang, Chengli Wang, Chenghui Liu,* Hui Wang, Zhengping Li.* Highly sensitive and specific multiplexed microRNA quantification using size-coded ligation chain reaction (LCR). Anal. Chem., 2014, 86, 1076-1082.
2. Chenghui Liu,* Lijuan Chang, Honghong Wang, Jie Bai, Wei Ren, Zhengping Li. Upconversion Nanophosphor: An Efficient Phosphopeptides-Recognizing Matrix and Luminescence Resonance Energy Transfer Donor for Robust Detection of Protein Kinase Activity. Anal. Chem., 2014, 86, 6095-6102.
1. Fangfang Wang, Chenghui Liu,* Yunlong Fan, Yucong Wang, Zhengping Li.* Robust detection of tyrosine phosphatase activity by coupling chymotrypsin-assisted selective peptide cleavage and a graphene oxide-based fluorescent platform. Chem. Commun., 2014, 50, 8161-8163.