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沈爱国，武汉大学化学与分子科学学院教授，博士生导师，中国物理学会光散射专业委员会委员，湖北省化学化工学会谱学专业委员会秘书长。2006年7月毕业于武汉大学化学与分子科学学院分析化学专业，获博士学位（导师：胡继明教授）。毕业后留校任教并连续3年赴德国不来梅Jacobs大学和韩国全南国立大学开展国际合作研究（每年3-4个月）。2008年12月晋升为副教授，2010年被遴选为博士生导师。2011年6月至2012年6月获德国DAAD-王宽诚博士后奖学金，在德国图宾根大学物理与理论化学所从事针尖增强拉曼光谱的合作研究（合作导师：Prof. Alfred J. Meixner和Dr. Dai Zhang）。2016年12月晋升为教授。现主要从事拉曼光谱的生化传感、生物成像及仪器研制等领域的研究工作。先后主持1项国家重大科学仪器设备开发项目，3项国家自然科学基金项目，1项中石油科技创新项目和2项国家重点实验室开放基金项目；参与1项国家自然科学基金仪器专项重点项目和1项国家重大研究计划培育项目。迄今已在Advanced Functional Materials, Analytical Chemistry, ScientificReports, ACS Applied Materials Interfaces, Journal of Materials Chemistry,Chemical Communications和Biosensors undefinedamp; Bioelectronics等杂志上发表SCI源刊论文70余篇。
沈爱国
研究领域与兴趣 1. 疾病（早期）诊断的拉曼光谱新技术与新仪器
2. 面向有机小分子和无机离子现场、快速分析的表面增强拉曼检测新原理和新器件
3. 新型表面增强拉曼光谱分子探针用于多元传感分析和生物成像 1. 《现代仪器分析方法与实践》（拉曼光谱）（研究生必修课） 2. 《激光分析》（研究生专业课程） 3. 《近代化学发展史》与《人文化学》（武汉大学通识课） 4. 《仪器分析实验》（红外与拉曼光谱） 1. 主持人，国家自然科学基金面上项目，“突破衍射极限的针尖增强拉曼显微镜在细菌生物被膜无标记、高灵敏检测中的应用”，2015-2018，批准号：21475100。 2. 主持人，国家重大科学仪器设备开发专项子项目，“激光拉曼光谱气体分析仪的研制”，2012-2015，批准号：2012YQ16000701。 3. 主持人，国家自然科学基金面上项目，“原位、活体检测植物激素的SERS探针新技术”，2012-2015，批准号：21175101。 4. 主持人，国家自然科学基金青年科学基金项目，“新型复合拉曼探针用于胃癌早期诊断的研究”，2008-2010，批准号：20705025。 5. 主持人，中国石油科技创新基金项目，“改善二氧化碳驱油关键技术研究”，2008-2010。 代表性论文：
- Xiang-Ru Bai, Yi Zeng, Xiao-Dong Zhou, Xiao-Hua Wang, Ai-Guo Shen,* Ji-Ming Hu, Environmentally safe mercury(II) ions aided zero-background and ultrasensitive SERS detection of dipicolinic acid, Analytical Chemistry, 2017, DOI: 10.1021/acs.analchem.7b02172.
- Yi Zeng, Jia-Qiang Ren, Shao-Kai Wang, Jia-Ming Mai, Bing Qu, Yan Zhang, Ai-Guo Shen*, Ji-Ming Hu, Rapid and reliable detection of alkaline phosphatase by a hot spots amplification strategy based on well-controlled assembly on single nanoparticle, ACS Applied Materials Interfaces, 2017, DOI: 10.1021/acsami.7b09336.
- Yi Zeng, Jia-Qiang Ren, Ai-Guo Shen*, Ji-Ming Hu*, Field and pretreatment-free detection of heavy-metal ions in organic polluted water through an alkyne-coded SERS test kit, ACS Applied Materials Interfaces, 2016, 8, 27772-27778.
- Meng-Yue Gao, Wei Fang, Jia-Qiang Ren, Ai-Guo Shen*, Ji-Ming Hu*, Reliable SERS detection of nitrite based on pH and laser irradiance-dependent diazotization through a convenient sampling micro-chamber, Analyst, 2016, 141, 5195 - 5201.
- Yong Chen, Jia-Qiang Ren, Xia-Guang Zhang, De-Yin Wu, Ai-Guo Shen*, Ji-Ming Hu*, Alkyne-modulated surface-enhanced Raman scattering-palette for optical interference-free and multiplex cellular imaging, Analytical Chemistry, 2016, 88, 6115-6119.
- Manman Lin, Bin Xu, Huilu Yao*, Aiguo Shen*, Jiming Hu, An in vivo quantitative Raman-pH sensor of arterial blood based on laser trapping of erythrocytes, Analyst, 2016, 141, 3027-3032.
- Yong Chen, Xiang-Ru Bai, Le Su, Zhan-Wei Du, Ai-Guo Shen*, Arnulf Materny, Ji-Ming Hu*,Combined labelled and label-free SERS probes for triplex three-dimensional cellular imaging, Scientific Reports, 2016, 6, 19173.
- Wei Fang, Xin-Wei Zhang, Yong Chen, Liang Wan, Wei-Hua Huang, Ai-Guo Shen*, Ji-Ming Hu*, Portable SERS-enabled micropipettes for microarea sampling and reliably quantitative detection of surface organic residues, Analytical Chemistry, 2015, 87, 9217-9224.
- Yi Zeng, Jin-Ju Pei,Li-Hua Wang, Ai-Guo Shen*, Ji-Ming Hu, A sensitive sequential "on/off" SERS assay for heparin with wider detection window and higher reliability based on the reversed surface charge changes of functionalized Au@Ag nanoparticles, Biosensors and Bioelectronics, 2015, 66, 55-61.
- Wen-Liang Zha, Ying Cheng, Wei Yu, Xiao-Bin Zhang, Ai-Guo Shen*, Ji-Ming Hu, HPLC assisted Raman spectroscopic studies on bladder cancer, Laser Physics Letters, 2015, 12, 045701.
- Guan-Nan Zhang, Jun-Rong Li, Ai-Guo Shen*, Ji-Ming Hu, Synthesis of size-tunable chitosan encapsulated gold-silver nanoflowers and their application in SERS imaging of living cells, Physical Chemistry Chemical Physics, 2015, 17, 21261-21267.
- Man-Man Lin#, Ai-Guo Shen#, Hui-Lu Yao*, Zhi-Zhi Zhang, Ji-Ming Hu*, Real-time molecular profiling of photochemically induced rat thrombosis in vivo through quantitative Raman analysis of blood, Laser Physics Letters, 2014, 11, 115607.
- Gan Qu, Guan-Nan Zhang, Zi-Tong Wu, Ai-Guo Shen*, Jian-Bo Wang, Ji-Ming Hu*, A "turn-off" SERS assay of heparin with high selectivity based on heparin-peptide complex and Raman labelled gold nanoparticles, Biosensors and Bioelectronics, 2014, 60, 124-129.
- Zi-Tong Wu, Yi-Zhen Liu, Xiao-Dong Zhou, Ai-Guo Shen*, Ji-Ming Hu*, A "turn-off" SERS-based detection platform for ultra sensitive detection of thrombin based on enzymatic assays, Biosensors and Bioelectronics, 2013, 44, 10-15.
- Guan-Nan Zhang, Gan Qu, Yong Chen, Ai-Guo Shen*, Wei Xie, Xiao-Dong Zhou, Ji-Ming Hu*, Controlling carbon encapsulation of gold nano-aggregates as highly sensitive and spectrally stable SERS tags for live cell imaging, Journal of Materials Chemistry B, 2013, 1, 4364-4369.
- Ai-Guo Shen, Jin Peng, Qing-Hong Zhao, Le Su, Xiao-Hua Wang, Ji-Ming Hu*, Qing Yang*, Accurate and noninvasive embryos screening during in vitro fertilization (IVF) assisted by Raman analysis of embryos culture medium, Laser Physics Letters, 2012, 9, 322-328.
- Pu Chen, Yong Chen, Le Su, Ai-Guo Shen*, Jun-Cheng Hu, Xiao-Hua Wang, Ji-Ming Hu*, β-Carotene doped silica nanoparticles as a novel resonance Raman scattering tag for in vivo cellular imaging, Journal of Materials Chemistry, 2012, 22, 631-635.
- Ai-Guo Shen, Jing-Zhe Guo, Wei Xie, Meng-Xiang Sun, Ryan M Richards, Ji-Ming Hu*, Surface-enhanced Raman spectroscopy in living plant using triplex Au-Ag-C core–shell nanoparticles, Journal of Raman Spectroscopy, 2011, 42, 879-884.
- Ai-Guo Shen, Li-Fang Chen, Wei Xie, Jun-Cheng Hu, Ao Zeng, Ryan M Richards, Ji-Ming Hu*, Triplex Au-Ag-C core-shell nanoparticles as a novel Raman labels, Advanced Functional Materials, 2010, 20, 969-975.
- Jing Shen, Li Fan, Jing Yang, Ai-Guo Shen*, Ji-Ming Hu*, A longitudinal Raman microspectroscopic study of osteoporosis induced by spinal cord injury, Osteoporosis International, 2010, 21, 81-87.
- Wei Xie, Li Wang, Yu-Ying Zhang, Ai-Guo Shen*, Jin-Quan Tan, Ji-Ming Hu*, Nuclear targeted nanoprobe for single living cell detection by surface-enhanced Raman scattering, Bioconjugate Chemistry, 2009, 20, 768-773.
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发表于 2018-3-27 21:11:42
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