方晓红,中国科学院化学研究所研究员,博士生导师。1990年毕业于武汉大学化学系,获学士学位。1993年和1996年分别于北京大学化学系获硕士学位和博士学位。1997年4月至1998年3月在加拿大滑铁卢大学化学系做博士后。1998年4月至2001年12月先后在美国佛罗里达大学化学系、生物技术中心及生物/纳米技术交叉研究中心做博士后、研究助理。2001年4月入选中科院百人计划,2001年12月回国工作,任中国科学院化学研究所分子纳米结构与纳米技术重点实验室研究员,博士生导师,兼中科院研究生院教授。
在发展高灵敏度的生物医学分析新方法、单分子水平研究DNA/蛋白质相互作用力和对蛋白质等生物大分子表征、细胞信号转导相关蛋白的活细胞单分子研究等方面取得了高水平的研究成果。已在PNAS、Acc. Chem. Res.、JACS、Angew. Chem. Int. Ed.、Nano Lett. Nucl.Acid. Res.、Anal. Chem.、J. Phy. Chem. 等国际学术期刊上发表论文140多篇。主持和作为主要成员承担和完成了国家自然科学基金委杰出青年基金、重大、重点基金和国家科技部、卫生部等多项科研项目, 2007年任科技部纳米重大科学研究计划项目首席科学家, 2012年获得持续支持,再次任纳米重大科学研究计划项目首席科学家。
方晓红
中国科学院化学研究所研究员,博士生导师
国家杰出青年基金获得者,科技部重大科学研究计划首席科学家
Tel/Fax: 010-62653083Email: xfang@iccas.ac.cn
教育背景
1990武汉大学理学学士
1993北京大学理学硕士
1996北京大学理学博士
出国学习工作
1997-1998加拿大滑铁卢大学博士后
1998-2001美国佛罗里达大学研究助理
工作简历
1997-1998加拿大滑铁卢大学博士后
1998-2001美国佛罗里达大学研究助理
2001年12月中科院化学所研究员,博士生导师
奖励信息
1.中科院引进国外杰出人才(百人计划,2001年),
2.国家自然科学基金委杰出青年科学基金 (2003年)
3.中国化学会青年化学奖(2003年)
4.中科院百人计划优秀入选者 (2005年)
5.中科院十大杰出妇女(2006年)
6.“新世纪百千万人才工程”国家级人选(2006年)
7.中国分析测试学会青年工作奖(2008年)
8. 中国侨界创新人才贡献奖 (2010年)
9.国务院政府特殊津贴(2010年)
代表性论文(from more than 110) :
- Single-Molecule Detection of Proteins Using Aptamer-Functionalized Molecular Electronic Devices, Liu, S.; Zhang, X., Luo, W., Wang, Z.., Guo, X.*, Steigerwald, M., Fang, X.*, Angew. Chem. Int. Ed. 2011,DOI: 10.1002/anie.201006469
- A single-molecule study of inhibition effect of Naringenin on transforming growth factor-b ligand-receptor binding, Yang, Y., Xu, Y., Xia, T., Chen, F., Zhang, F., Liang, W., Fang, X.* , Chem. Commun. 2011, 47, 2982-2984
- A Water-Soluble C60-Porphyrin Compound for Highly Efficient DNA Photocleavage, Zhou, C.*, Liu, Q., Xu, W., Wang, C. and Fang, X.*, Chem. Commun., 2011, 47, 2982-2984
- Elasticity of Cardiac Cells on the Polymer Substrates with Different Stiffness: An Atomic Force Microscopy Study, Shi, X., Qin, L., Zhang, X., He, K., Xiong, C., Fang, J., Fang, X.*, Zhang, Y.*, Phys. Chem. Chem. Phys., 2011, 13 (16), 7540-5.
- Single-Molecule Imaging Revealed Enhanced Dimerization of Transforming Growth Factor β Type Ⅱ Receptors in Hypertrophic Cardiomyocytes” He, K., Fu, Y., Zhang, W., Yuan, J., Li, Z., Lv, Z., Zhang, Y*, Fang, X.* Biochem. Biophy. Res. Commun., 2011,407,313-317.
- Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signaling transduction,Yang, Y., Xia, T., Zhang, W., Fang, X.* Chinese Science Bulletin, 2011, 56(11), 1063-67.
- TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs. Huang T, David L, Mendoza V, Yang Y, Villarreal M, De K, Sun L, Fang X, López-Casillas F, Wrana JL, Hinck AP,EMBO J. 2011,30(7): 1263-76.
- Aptamers Generated from Cell-SELEX for Molecular Medicine:A Chemical Biology Approach, Fang, X.* and Tan, W*, Acc. Chem. Res., 2010, 43, 48-57.
- Intercellular transportation of quantum dots mediated by membrane nanotubes, He, K., Luo, W., Zhang, Y., Liu, F., Liu, D., Xu, L., Qin, L., Xiaong, C., Lu, Z., Fang, X.*, Zhang, Y.*, ACS Nano, 2010, 4,3015-3022.
- Study of the inhibitory effect of water-soluble fullerenes on plant growth at the cellular level. Liu, Q., Zhao, Y., Wan, Y., Zhang, J., Zhang, X., Wang, C., Fang, X. * and Lin., J.* , ACS Nano, 2010, 4,5743-5748.
- Monomeric Type I and Type III Transforming Growth Factor-β Receptors and Their Dimerization, Zhang, Z., Yuan, J., Yang, Y., Xu, L., Wang, Q., Fang, X.*, Chen, Y.*, Cell Res., 2010. 20,1216-1223.
- Single-Molecule Imaging Reveals Transforming Growth Factor-b-induced Type II Receptor Dimerization. Zhang, W., Jiang, Y., Wang , Q., Ma, X., Xiao, Z., Zuo, W., Fang, X.*, Chen, Y.* Proc. Natl. Acad. Sci. USA, 2009, 106, 15679-15683.
- Carbon Nanotubes as Molecular Transporters for Walled Plant Cells, Liu, Q., Bo. C., Wang, Q., Shi, X., Xiao, Z., Lin., J., and Fang, X. *, Nano Letters, 2009, 9: 1007-1010.
- Study of inhibition effect of herceptin on interaction between heregulin and ErbB receptors HER3/HER2 by single-molecule force spectroscopy, Shi, X., Xu, L., Yu., J., and Fang, X. *, Exp. Cell. Res. 2009.
- Molecular engineering of DNA: molecular beacons.K. Wang*, Z. Tang, C. Yang, Y. M. Kim, X. Fang, W. Li, Y. Wu, C. Medley, Z. Cao, J. Li, P. Colon, H. Lin, W. Tan*. Angew. Chem. Int. Ed., 2009, 48, 856-870.
- Hydrodynamically Focused Stream as a Dynamic Template for Site-Specific Electrochemical Micropatterning of Conducting Polymers, Hou, S., Wang, S., Zeta, T., Yu, F., Nicole, Q., Zhu, M., Clifton, K,. Shen, F., Fang, X. *, Tseng, H.*, Angew. Chem. Int. Ed. 2008, 47,1072-1075
- Single-Molecule Study of Lateral Mobility of Epidermal Growth Factor Receptor 2/HER2 on Activation,Z. Xiao, X. Ma, Y. Jiang, Z. Zhao, B. Lai, J. Liao, J. Yue and X. Fang*,J. Phy. Chem. B, 2008, 112: 4140-4145.
- Detection of trace Hg2+ via induced circular dichroism of DNA wrapped around single-walled carbon nanotubes. X. Gao, G. Xing, Y. Yang, X. Shi, R. Liu, W. Chu, L. Jing, F. Zhao, C. Ye, H. Yuan, X. Fang, C. Wang, and Y. Zhao. J. Am. Chem. Soc., 2008, 130: 9190–9191.
- TINY, a dehydration-responsive element(DRE)-binding protein-like transcription factor connecting the DRE-and ethylene-responsive element-mediated signaling patheways in Arabidopsis. S. Sun, J. Yu, F. Chen, T. Zhao, X. Fang, Y. Li, and S. Sui. J. Biol. Chem. 2008, 283: 6261-6271.
- Single-Molecule Study of EGFR Mobility Implicates the its Association with Caveolae/Clathrin After Activation,Z. Xiao, W. Zhang, Y. Yang, L. Xu, X. Fang* Biochem Biophys Res Commun. 2008, 369: 730-734.
- Conjugation of a Water-Soluble Gadolinium Endohedral Fulleride with an Antibody as a Magnetic Resonance Imaging Contrast Agent, Shu,C., Ma, X., Zhang, J., Corwin, F., Sim, J., Zhang, E., Dorn, H., Gibson, H., Fatouros, P., Wang, C.*, Fang, X. * Bioconjugate Chem., 2008, 19: 651-655.
- Cell-specific Internalization study of an Aptamer From Whole Cell Selection, Xiao, Z., Shangguan, D., Cao, Z., Fang, X. and Tan, W. *, Chem. Eur. J., 2008, 14, 1679-1755.
- Single Molecule Force Spectroscopy Study of Interaction between Transforming Growth Factor B and its Receptor in Living Cells,Yu., J., Wang Q., Shi X. , Ma, X., Yang H., Chen, Y., Fang, X*, J. Phy. Chem. B, 2007, 111(48):13619-13625
- Lateral Diffusion of TGF-b Type Receptor Studied by Single Molecule Imaging, Ma, X., Wang,Q., Jiang, Y., Xiao, Z., Fang, X. *, Chen, Y*., Biochem Biophys Res Commun. 2007, 292, 31-40.
- Interaction between Single Molecules of Mac-1 and ICAM-1 in Living Cells: An Atomic Force Microscopy Study, Yang, H., Yu, J. Fu, G., Shi, X., Xiao, L., Chen, Y., Fang, X*., Chen, H*., Exp. Cell. Res. 2007, 331, 3497-3504
- Energy Landscape of Aptamer/Protein Complex Studied by Single Molecular Force Spectroscopy, Yu., J., Jiang, Y., Ma, X., Fang, X. * Chem. Asia. J., 2007, 2, 284-289.
- Fluorescence study of DNA binding and bending by EcoRI DNA methyltransferase, Ma,B., Wang, J., Fang, X. *, J. Phy. Chem. B, 2006,110, 19647-19651.
- Single Molecule Study of Binding Force Between Transcription Factor TINY and Its DNA Responsive Element, Yu, J., Sun, S., Jiang, Y., Ma, X., Chen, F., Zhang, G., Fang, X*., Polymer, 2006, 47, 2533-2538.
- Detection of Oncoprotein Platelet-Derived Growth Factor Using Fluorescent Signaling Complex of Aptamer and TOTO,Zhou, C. Wang, J., Jiang, Y., Hou, S., Fang, X. *, Anal. Bioanal. Chem., 2006, 384, 1175-1180.
- Aptamer Based ATP Assay Using a Luminescent Light Switching Complex, Wang, J., Jiang, Y., Zhou, C., Fang, X *. Anal. Chem., 2005, 77,3542-3546. (5.6)
- Study of Fibrinogen Adsorption on Self-Assembled Monolayers on Au(111) by Atomic Force Microscopy,Lin ,Y., Wang, J., Wan L. , Fang X. *, Ultramicroscopy, 2005, 105, 129-136.
- Study of the Single Molecular Interaction of the Transcription Factor ZmDREB1A with its DNA Responsive Element by Atomic Force Microscopy. Jiang, Y. X., Feng, Q., Fang, X*, Bai, C *. Nucl.Acid.Res. 2004, 32(12): e101.
- Signaling Aptamer/Protein Binding by a Molecular Light-Switch Complex. Jiang, Y., Fang, X *, Bai, C *. Anal. Chem. 2004, 76, 5230-5235.
- Delaying Photobleaching and Recovering Luminescence of a DNA Molecular Light Switch in DNA Analysis, Ling, L., Jiang, Y., Wang, C., Fang, X.*, Wan, L. He, Z., Bai, C.*, Chen.,D.*, Anal. Biochem. 2004, 329, 334-336.
- Specific Aptamer - Protein Interaction Studied by Atomic Force Microscopy. Jiang, Y., Zhu, C. F., Ling, L., Wan, L., Fang, X *, Bai, C.*, Anal. Chem., 2003, 75(9): 2112-2116.
- Study of Citrate Adsorbed on the Au(111) Surface by Scanning Probe Microscopy. Lin, Y., Pan, G.., Su, G. ., Fang, X.*, Wan, L.*., Bai, C.*. Langmuir 2003, 19, 10000-1003
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