北京大学化学与分子工程学院夏斌

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夏斌，北京大学教授，教育部“长江学者奖励计划”特聘教授。北京核磁共振中心主任兼首席科学家、北京大学化学与分子工程学院物理化学专业博士生导师、北京大学生命科学学院生物化学与分子生物学专业博士生导师。研究兴趣：蛋白质结构与功能关系的核磁共振谱学研究；蛋白质的结构基因组学研究；疾病的代谢组学研究。

夏斌 博士
北京大学  教授，博士生导师
北京核磁共振中心(BNMRC) 主任及首席科学家
地址：100871 北京大学，北京核磁共振中心
电话: 010-6275-8127
传真: 010-6275-3790
E-mail: binxia@pku.edu.cn


教育背景
1989-1997 美国 University of  Wisconsin-Madison 生物物理学 博士
1985-1989 北京大学 生物系 生理学及生物物理学 学士
工作经历
2001至今 北京核磁共振中心  主任及首席科学家
北京大学 长江特聘教授
北京大学 化学与分子工程学院 分析化学专业        博士生导师
北京大学 生命科学学院 生物化学与分子生物学专业        博士生导师
1997-2001 美国 The Scripps Research  Institute 分子生物学系         博士后
         
科研方向
利用核磁共振（NMR）技术，结合其它生物化学及分子生物学手段，研究生物大分子结构及其相互作用，以期理解其结构-功能关系，揭示其作用的分子机理。目前主要的研究对象包括细胞凋亡因子Bcl-xL、抑癌基因H-REV-107家族蛋白、结核杆菌nucleoid protein Lsr2、SARS病毒主蛋白酶等。

代表性论文
1. B. R.G. Gordon, Y Li, A. Coteb, M. T. Weirauch, P. Ding, T. R. Hughes, W. W. Navarre, B. Xia*, and J. Liu* , “Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins” , Proc. Natl. Acad. Sci. , 2011 , 108:10690-5　　
2. J. Zhou, J. Lin, C. Zhou, X. Deng, & B. Xia* , “An improved bimolecular fluorescence complementation tool based on superfolder green fluorescent protein” , Acta Biochim. Biophys. Sin , 2011 , 43: 239-44　　
3. L. Wang, X. Ren, Y. Li, N. Rouhier, J. P. Jacquot, C. Jin, B. Xia* , "1H, 13C, and 15N resonance assignments of reduced GrxS14 from Populus tremula x tremuloides". , Biomol NMR Assign , 2011 , 5, 121-4　　
4. W. Gong, J. Wang, Z. Chen, B. Xia*, and G. Lu* , “Solution Structure of LCI, a Novel Antimicrobial Peptide from Bacillus subtilis” , Biochemistry , 2011 , 50: 3621-7　　
5. F. Song, X. Zhang, X. Ren, P. Zhu, J. Xu, L. Wang, Y. Li, N. Zhong, Q. Ru, D. Zhang, J. Jiang, B. Xia*, & Z. Chen* , “Cyclophilin A (CyPA) induces chemotaxis independent of its peptidylprolyl Cis-trans isomerase activity: Direct binding between CyPA and the ectodomain of CD147” , J. Biol. Chem. , 2011 , 286: 8197-203　　
6. J. Zhou, J. Lin, C. Zhou, X. Deng, & B. Xia* , “Cytotoxicity of Red Fluorescent Protein DsRed is Associated with the Suppression of Bcl-xL Translation” , FEBS Lett. , 2011 , 585: 821-7　　
7. B. Xia* and X. Kang , “Activation and Maturation of SARS-CoV Main Protease” , Protein Cell , 2011 , 2: 282-90　　
8. S. Zhang, N. Zhong, X. Ren, C. Jin, B. Xia* , "(1)H, (13)C and (15)N resonance assignments of SARS-CoV main protease N-terminal domain" , Biomol NMR Assign , 2010 , Biomol NMR Assign　　
9. S. Tian, J. Lin, J. Zhou, X. Wan, Y. Li, X. Ren, W. Yu, W. Zhong, J. Xiao, F. Sheng, Y. Chen, C. Jin, S. Li, Z. Zheng, and B. Xia* , “Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound Z18” , Autophagy , 2010 , 6: 1032-41　　
10. S. Zhang, N. Zhong, F. Xue, X. Kang, X. Ren, J. Chen, C. Jin, Z. Lou and B. Xia* , “3D domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease” , Protein Cell , 2010 , 1: 371–83　　
11. X. Ren, J. Lin, C. Jin, and B. Xia* , “Solution structure of the N-terminal catalytic domain of human H-REV107 - a novel circular permutated NlpC/P60 domain”, , FEBS Lett. , 2010 , 584:4222-6　　
12. J. Hu, D. Li, X.-D. Su, C. Jin, and B. Xia* , “Solution Structure and Conformational Heterogeneity of Acylphosphatase from Bacillus subtilis” , FEBS Lett. , 2010 , 584: 2852-2856　　
13. J. Lin, N. Wang, Y. Li, Z. Liu, S. Tian, L. Zhao, Y. Zheng, S. Liu, S. Li, C. Jin, and B. Xia , “LEC-BiFC: A New Method for Rapid Assay of Protein Interaction” , Biotech. Histochem. , 2010 , DOI: 10.3109/10520295.2010.483068　　
14. X. Ren, J. Lin, C. Jin, and B. Xia* , “1H, 13C and 15N resonance assignments of human H-REV107 N-terminal domain” , Biomol. NMR Assign , 2010 , 4: 175-8　　
15. B. R.G. Gordon, Y. Li , L. Wang , A. Sintsova , H. V. Bakel , S. Tian, W. W. Navarre, B. Xia*, and J. Liu* , “Lsr2 is A Nucleoid-Associated Protein that Targets AT-Rich Sequences and Virulence Genes in Mycobacterium tuberculosis”, , Proc. Natl. Acad. Sci. , 2010 , 107: 5154-5159　　
16. J. Lin, Z. Zheng, Y. Li, W. Yu, W. Zhong, S. Tian, F. Zhao, X. Ren, J. Xiao, N. Wang, S. Liu, L. Wang, F. Sheng, Y. Chen, C. Jin, S. Li, and B. Xia* , “A Novel Bcl-XL Inhibitor Z36 that Induces Autophagic Cell Death in Hela Cells” , Autophagy , 2009 , 5: 314-320　　
17. J. Hu, G. Cui, C. Li, C. Liu, E. Shang, L. Lai, C. Jin, J. Wang, and B. Xia* , “Structure and Novel Functional Mechanism of Drosophila SNF in Sex-lethal Splicing” , PloS ONE , 2009 , 4: e6890　　
18. N. Zhong, S. Zhang, F. Xue, X. Kang, P. Zou, J. Chen, C. Liang, Z. Rao, C. Jin, Z. Lou, and B. Xia* , “C-Terminal Domain of SARS-CoV Main Protease Can Form a 3D Domain-Swapped Dimer” , Protein Sci. , 2009 , 18: 839-44　　
19. T. Wang, K. Shao, Q. Chu, Y. Ren, Y. Mu, L. Qu, J. He, C. Jin, and B. Xia* , “Automics: An Integrated Platform for NMR-Based Metabonomics Spectral Processing and Data Analysis” , BMC Bioinformatics , 2009 , 10: 83　　
20. N. Guo, R. Zhang, F. Song, J. He, B. Xia, and Z. Abliz , “Characterization of Acid-Induced Protein Conformational Changes and Noncovalent Complexes in Solution by Using Coldspray Ionization Mass Spectrometry” , J. Am. Soc. Mass. Spectrom. , 2009 , 20: 845-51　　
21. W. Yu, J. Lin, C. Jin, and B. Xia* , “Solution Structure of Human Zeta-COP: Direct Evidences for Structural Similarity between COP I and Clathrin-Adaptor Coats” , J. Mol. Biol. , 2009 , 386: 903-912　　
22. S. Fan, Y. Feng, Z. Wei, B. Xia*and W. Gong , “Solution Structure of Synbindin Atypical PDZ Domain and Interaction with Syndecan-2” , Protein Pept. Lett. , 2009 , 16: 189-195　　
23. W. Yu, J. Hu, B. Yu, W. Xia, C. Jin, and B. Xia* , “Solution Structure of GSP13 From Bacillus subtilis Exhibits an S1 Domain Related to Cold Shock Proteins” , J. Biomol. NMR. , 2009 , 43: 255-259　　
24. W. Gong, Y. Li, G. Cui, J. Hu, H. Fang, C. Jin, and B. Xia* , “Solution Structure and Catalytic Mechanism of Human Protein Histidine Phosphatase 1”, , Biochem. J. , 2009 , 418: 337-344