南开大学化学学院黄有

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黄有 教授：南开大学化学院和元素有机化学国家重点实验室教授、博士生导师。多年来一直从事有机合成化学方面的研究工作，主要研究方向为有机磷化学和有机合成化学。在功能有机磷化合物的设计合成及性能研究、新型有机膦催化剂的设计合成及催化反应研究、有机膦小分子催化的调控 Domino 反应、有机小分子催化的不对称反应研究等方面取得多项突破性研究成果，在 Chem. Eur. J. 等国际著名期刊 发表代表性学术论文十余篇。


姓　　名        黄有        
性　　别        男
出生年月        1962-10        
籍　　贯        河南洛阳栾川县
学　　历        博士        
毕业院校        浙江大学
职　　称        教授        
系所单位        元素有机化学研究所        
通讯地址        南开大学元素所
电 话        23503159
电子邮件        hyou@nankai.edu.cn
课题组网站        http://skleoc.nankai.edu.cn/professors/huangy/huangyou.htm


研究领域        
研究方向：
1.有机磷化学
2.有机合成化学
3.杂原子有机化学
在研项目：
1.新型多官能团有机膦催化剂的设计、合成以及在对映选择性的Rauhut–Currier相关反应中的应用
国家自然科学基金（21672109）
2017.1-2020.12
2.有机膦催化的分子间连续环化Domino反应构筑双环 [m. n. 0]骨架
国家自然科学基金(21472097)
2015.1-2018.12
3.有机膦催化的多环体系的高效构筑方法研究
天津市自然科学基金 (15JCYBJC20000)
2015.4-2018.3


教育及科研经历        
Education:
1982-1986年 河南师范大学化学系 本科
1986-1989年 河南师范大学化学系 硕士研究生
1994-1997年 浙江大学化学系 博士研究生
1989-1994年 河南师范大学化学系 助教、讲师
1997-1999年 南开大学元素所 博士后
1999-2002年 大阪大学药学院 博士后
2002-2008年 南开大学化学院 副教授
2008-2011年 南开大学化学院 教授
2011年至今 南开大学化学院 教授，博士生导师


荣誉和奖励        
2004年，获南开大学敬业奖教金教学二等奖
2013年，获南开大学敬业奖教金教学二等奖
2013年，获南开大学校级“教工先锋岗”先进个人
2013年，获南开大学第五届“良师益友”提名奖


科研成果与代表作        
代表性论文：
1 Sequential [1+4]- and [2+3]-Annulation of Prop-2-ynylsulfonium Salts: Access to Hexahydropyrrolo[3,2-b]indoles
Jia, Penghao; Zhang, Qinglong; Ou, Qima and Huang You*
Org. Lett., 2017, 19, 4664-4667.
2 Divergent Synthesis of Hydropyridine Derivatives via Nitrogen Containing Lewis Base Mediated Regioselective [4+2] Cyclizations
Jin, Hongxing; Li, Erqing and Huang You*
Org. Chem. Front., 2017, 4, Doi: 10.1039/C7QO00596B.
3 Phosphine-Catalyzed Intramolecular Rauhut-Currier Reaction: Enantioselective Synthesis of Hydro-2H-Indole Derivatives
Jin, Hongxing; Zhang, Qinglong; Li, Erqing; Jia, Penghao; Li, Ning and Huang You*
Org. Biomol. Chem. 2017, 15, 7097-7101.
4 Phosphine-Mediated Sequential Annulation Reaction: Access to Functionalized Benzofurans and 4,5-Dihydrobenzofurans
Liang, Ling; Dong, Xuelin and Huang You*
Chem. Eur. J., 2017, 23, 7882-7886.（Hot Paper)
5 A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo [4.3.0] derivates
Zhang, Qinglong; Zhu, Yannan; Jin, Hongxing and Huang You*
Chem. Commun., 2017, 53, 3974-3977.
6 [3 + 2]-Annulation of Prop-2-ynylsulfonium Salts: Access to Hydroindol-5-ones Containing a Methylthio Group
Jia, Penghao; Zhang, Qinglong; Jin, Hongxing and Huang You*
Org. Lett. 2017, 19, 412-415.
7 Bifunctional Phosphine Catalyzed Sequential Annulations of Allenoates and Ketimines: Construction of Functionalized Poly-heterocycle Rings
Li, Erqing; Jin,Hongxing; Jia, Penghao; Dong, Xuelin and Huang You*
Angew. Chem. Int. Ed. 2016, 55 (38), 11591-11594 DOI:10.1002/anie.201605189).
8. Sequential Annulations Domino Reaction of Sulfur Ylides and ???-Unsaturated Cyclic Ketimines: Synthesis of Cyclic 2-Alkenyl Aziridines
Jia, Penghao and Huang You*
Org. Lett. 2016, 18(10), 2475-2478.
9 Phosphine-Catalyzed [3 + 3]-Domino Cycloaddition of Ynones and Azomethine Imines To Construct Functionalized Hydropyridazine Derivatives
Liang, Ling and Huang You*
Org. Lett. 2016, 18(11), 2604-2607.
10 One-Pot Synthesis of Polysubstituted Benzenes through a N,N-dimethyl-4-aminopyridine (DMAP)-Catalyzed [4+2] Benzannulation of 1,3-Bis(sulfonyl)butadienes and g-Substituted Allenoates
Chang, Meijia; Wu, Chengzhou; Zheng, Jie and Huang You*
Chem. Asian J. 2016, 11(5), 1512-1517（Hot Paper)
11 DABCO-Mediated [4 + 4]-Domino Annulation: Access to Functionalized Eight-Membered Cyclic Ethers
Liang, Ling; Li, Erqing; Dong, Xuelin and Huang You*
Org. Lett. 2015, 17(19), 4914?4917.
12 Highly Enantioselective Intermolecular Cross Rauhut–Currier Reaction Catalyzed by a Multifunctional Lewis Base Catalyst
Dong, Xuelin; Liang, Ling; Li, Erqing and Huang You*
Angew. Chem. Int. Ed. 2015, 54, 1621-1624. （Hot Paper）
13 Divergent Phosphine-Catalyzed [2+4] or [3+2] Cycloaddition Reactions ofγ-Substituted Allenoates with Oxadienes
Li, Erqing; Chang, Meijia; Liang, Ling and Huang You*
Eur. J. Org. Chem. 2015, 710–714. （Hot Paper)
14. Morita–Baylis–Hillman adduct derivatives (MBHADs): versatile reactivity in Lewis base-promoted annulation
Xie, Peizhong and Huang You*
Org. Biomol. Chem. 2015, 13(32), 8578–8595
15. A Sulfur Ylides-Mediated Domino Benzannulation Strategy to Construct Biaryls, Alkenylated and Alkynylated Benzene Derivatives
Gao Fei and Huang You*
Adv. Synth. Catal. 2014, 356, 2422-2428.
16 Phosphine-catalyzed Domino Reaction: A Novel Sequential [2+3] and [3+2] Annulation Reaction of γ-Substituent Allenoates to Construct Bicyclic[3, 3, 0]octene Derivatives.
Li, Erqing; Huang, You*
Chem. Commun., 2014, 50 (8), 948-950.
17 Sequential Catalyst Phosphine/Secondary Amine-Promoted [1+4]/ Rearrangement Domino Reaction for the Construction of (2H)-Pyrans and 2-oxabicyclo[2.2.2]oct-5-ene Skeletons
Xie, Peizhong; Yang, Jie; Zheng, Jie; Huang, You*
Eur. J. Org. Chem., 2014, 1189-1194.
18 Phosphine-Catalyzed Domino Reaction: A Novel Method Access to Functionalized
Bicyclic Skeletons
Li, Erqing; Huang, You*
Chem. Eur. J., 2014, 20, 3520
19 Phosphine Initiated Domino Reaction: A Convenient Method for the Preparation of Spiro-cyclopentanones
Liang, Ling; Li, Erqing; Xie, Peizhong; Huang You*
Chem. Asian J. 2014, 9(5), 1270-1273
20 Phosphine-Catalyzed Sequential [2 +3] and [3 + 2] Annulation Domino Reaction of γ- Benzyl Substituted Allenoates with α,β-Unsaturated Ketimines To Construct Aza-bicyclo[3, 3, 0]octane Derivatives
Li, Erqing; Jia, Penghao; Liang, Ling; Huang, You*
ACS Catal. 2014, 4, 600?603.
21 A simple and highly efficient procedure for construction of quaternary carbons centers by tributylphosphine catalyzed bis-Michael addition
Xu, Da-Zen; Zhan, Ming-Zhe; Huang, You*
Tetrahedron 2014, 70, 176-180
22 One step Synthesis of Benzoxazepine Derivatives via a PPh3 Catalyze aza-MBH Domino Reaction between Salicyl N-tosylimines and Allenoates.
Zhao, Hongxia; Meng, Xiangtai; Huang, You*
Chem. Commun., 2013, 49(89), 10513-10515.
(Highlighted by Prof. Snieckus, V and Guimar?es, K. G. in Synfacts 2014, 10(1), 0027)
23 Phosphine-Catalyzed Domino Reaction: An Efficient Method for the Synthesis of Bicyclo[3.2.0]heptenes Skeleton.
Zheng, Jie; Huang, You*; Li, Zhengming
Org. Lett. 2013, 15(22), 5758-5761.
24. Phosphine-Catalyzed Domino Benzannulation: An Efficient Method to Construct Biaryl Skeletons.
Zheng, Jie; Huang, You*; Li, Zhengming
Org. Lett. 2013, 15(19), 5064-5067.
25. Phosphine-Catalyzed [4+2] Annulation of gamma-Substituent Allenoates: Facile Access to
Functionalized Spirocyclic Skeletons.
Li, Erqing; Huang, You*; Liang, Ling; Xie Peizhong
Org. Lett. 2013, 15(12), 3138-3141.
26. Tunable Phosphine-Mediated Domino Reaction: Selective Synthesis of 2,3-Dihydrofurans and Biaryls
Xie, Peizhong; Li, Erqing; Zheng, Jie; Li, Xin; Huang, You*; Chen, Ruyu
Adv. Synth. Catal. 2013, 355(1), 161 – 169. （Hot Paper)
27. Tuning Catalysts to Tune the Products: Phosphine-Catalyzed Aza-Michael Addition Reaction of Hydrazones with Allenoates.
Li, Erqing; Xie, Peizhong; Yang, Lihua, Liang Ling, Huang You*.
Chem. Asian J. 2013, 8(3) , 603-610.
28. Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the Construction of Carbocyclic Spirooxindoles Skeletons
Hu, Chongchong; Zhang, Qinglong; Huang, You*
Chem. Asian J. 2013, 8(9) , 1981-1984
29. Domino Cyclization Initiated by Cross-Rauhut-Currier Reactions
Xie, Peizhong; Huang, You*
Eur. J. Org. Chem. 2013, (20), 6213–6226.
30. Sulfur Ylides Participating Domino Cyclization Reaction.
Li Gongchun; Wang Liye; Huang You*
Chin. J. Chem. 2013, 33(9), 1900-1918.
31. Phosphine-catalyzed Domino Reaction: an Efficient Method for the Synthesis of Highly Functionalized Spirooxazolines.
Yang, Lihua; Xie, Peizhong; Li, Erqing; Li, Xin; Huang, You*; Chen, Ruyu
Org. Biomol. Chem. 2012, 10(37), 7628-7634.
32. Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the Construction of Highly Functionalized Cyclopentene.
Hu, Chongchong; Geng, Zhishuai; Ma, Jianze; Huang, You*; Chen, Ruyu
Chem. Asian J. 2012, 7(9) , 2032-2035.
33. Phosphine-mediated Domino Benzannulation Strategy for the Construction of Highly Functionally Multi-aryl Skeletons
Xie, Peizhong; Huang, You*; Chen, Ruyu
Chem. Eur. J. 2012, 18(24), 7362-7366 (Most accessed article 2012.5)
34. Phosphine-Catalyzed Domino Reaction for the Synthesis of Conjugated 2,3-Dihydrofurans from Allenoates and Nazarov Reagents and the Mechanism Investigation
Xie, Peizhong; Lai, Wenqing; Geng Zhishuai; Huang, You*; Chen, Ruyu
Chem. Asian J. 2012, 7(7) , 1533-1537
35. Bifunctional phosphine-catalyzed Cross-Rauhut-Currier/Michael/Aldol Condensation Triple Domino Reaction: Synthesis of Functionalized cyclohexenes.
Xie, Peizhong; Huang, You*; Lai, Wenqing; Meng, Xiangtai; Chen, Ruyu.
Org. Biomol. Chem. 2011, 9(19), 6707-6714.
36. Domino Reaction for the Chemo- and Stereoselective Synthesis of Trans-2,3-Dihydrobenzofurans from N-Thiophosphinyl Iimines and Sulfur Ylides.
Xie, Peizhong; Wang, Liye; Yang, Lihua; Li, Erqing; Ma, Jianze; Huang, You*; Chen, Ruyu.
J. Org. Chem. 2011, 76(19), 7699-7705
37. Substrate-Controlled Phosphine-Catalyzed Domino Reactions of Activated Conjugated Dienes: Highly Diastereoselective Synthesis of Bicyclic Skeletons.
Ma, Jianze; Xie, Peizhong; Hu, Chongchong; Huang, You*; Chen, Ruyu.
Chem. Eur. J. 2011, 17(27), 7418-7422 （Hot Paper)
38. N-Heterocyclic Carbene-Catalyzed (NHC) Three-Component Domino Reactions: Highly
Stereoselective Synthesis of Functionalized Acyclic ε-Ketoesters.
Ma, Jianze; Huang, You*; Chen, Ruyu.
Org. Biomol. Chem. 2011, 9(6), 1791-1798
39. Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Ssynthesis of Trans-2,3-Dihydrobenzofurans from Salicyl N-Thiophosphinyl Imines and Allylic Carbonates.
Xie, Peizhong; Huang, You*; Chen, Ruyu.
Org Lett. 2010, 12(17), 3768-3771.
40. PPh3-Catalyzed Domino Reaction: A Facile Method for the Synthesis of Chroman Derivatives.
Meng, Xiangtai; Huang, You*; Zhao, Hongxia; Xie, Peizhong; Ma, Jianze; Chen, Ruyu.
Org. Lett. 2009, 11(4), 991-994.
41. Bifunctional Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Synthesis of cis-2,3-Dihydrobenzofurans from Salicyl N-Thiophosphinyl Imines and Allenes.
Meng, Xiangtai; Huang, You*; Chen, Ruyu.
Org Lett. 2009, 11(1), 137-140.
42. A Novel Selective aza-Morita-Baylis-Hillman (aza-MBH) Domino Reaction and aza-MBH Reaction of N-Sulfonated Imines with Acrolein Catalyzed by a Bifunctional Phosphine Organocatalyst.
Meng, Xiangtai; Huang, You*; Chen, Ruyu.
Chem. Eur. J. 2008, 14(23), 6852-6856.（Hot Paper， Most accessed article 2008.7)


人才培养        已培养博士生7名，硕士生18名，本科生16名，在读博士生5名，硕士生4名。
在读博士研究生：贾鹏昊，金红星，李宁，冯佳旭， 陈俊龙
在读硕士研究生： 殷仲墨, 朱晏楠，蔡卫，周一鸣
在组本科生：朱子琦，王丹，戴畅航，欧其玛，李隗星月
已毕业研究生：
博士：孟祥太（2009）解沛忠（2013）郑洁（2014） 李二庆（2015） 董雪林（2015） 梁玲（2016）张庆龙（2017）
硕士：冯德鑫（2004）谷迎春、王金亮（2006）于雅琴（2007）徐大振（2008）张葵、崔萌（2009）赵红霞、邵永臣（2010）马俭泽、熊琴平（2011）王利叶、杨丽华（2012） 胡冲冲（2013）高飞（2014）杨杰（2015） 常美佳（2016） 吴成洲（2017）
本科生：徐大振（2004）潘璐，邹官军（2005）赵红霞（2006）韩百亮，何东明（2007）刘堂林（2008）来文庆，陈羽琛（2010）耿志帅（2012）陈凯宏（2013）郑彦明（2015）李宁（2016）张岩（2016）唐庆煊（2017）修文（2017））

xiaoqiuyu

2018自然科学基金项目-膦促进的选择性从头合成多取代苯
批准号        21871148        学科分类        合成与制备技术 ( B010101 )
负责人        黄有        职称                单位名称        南开大学
资助金额        64万元        项目类别        面上项目        起止年月        2019年01月01日 至 2022年12月31日

shuncha

4月29日上午，南开大学元素有机国家重点实验室黄有教授应南京工业大学化学与分子工程学院邀请，为我院师生作了一场题为“有机膦催化剂的设计合成及催化反应”的学术报告。
黄有教授首先介绍了有机膦化合物相关反应的研究背景和研究进展，同时结合自身的科研实践经历详细地介绍了所在课题组在有机膦小分子催化领域的最新研究成果，尤其是手性双官能团催化剂在分子间不对称Rauhut-Currier反应方面的突破性进展。为了让大家对这一领域的科研学术成果有更深入的了解，黄教授同时重点介绍了双官能团有机膦催化剂的设计及催化下的调控Domino环化及连续环化反应进展。在最后的交流互动环节，学生们针对不理解的问题进行了踊跃地提问，黄教授对这些问题做了深入浅出的讲解，让大家深受启发。本次讲座拓展了广大师生的科研视野，提升了我院的学术氛围，对我院的学科建设起到了良好的促进作用。