武汉大学化学与分子科学学院有机化学研究所董秀琴

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董秀琴

博士 , 副教授
研究方向： 不对称催化与合成
联系电话：
Email: xiuqindong-chem@whu.edu.cn

教育与研究经历

2015--至今    武汉大学化学与分子科学学院   副教授   硕士生导师

2012--2014    香港科技大学化学系   博士后研究  导师：Prof. Jianwei Sun

2007--2012    武汉大学化学与分子科学学院  硕博连读  导师：王春江教授

2003--2007    黄冈师范学院化学学院 学士

研究兴趣

(1) 发展新型手性膦配体及其在不对称催化反应中的应用研究

(2) 发展有机-金属配体及其在不对称催化反应中的应用研究

(3) 运用不对称催化反应高效构建手性药物或生物活性分子关键中间体

本科生《有机化学实验》、化学院《有机化学》

（1）主持国家自然科学基金青年项目(21502145，2016.1-2018.12)

（2）主持湖北省自然科学基金面上项目(2016CFB449，2016.1-2017.12)

（3）主持武汉市青年科技晨光项目(2017050304010307，2017.9-2019.12)

获奖情况：

2008年 武汉大学优秀研究生“三星专项奖学金”

2009年 1) 武汉大学“优秀研究生甲等奖学金”

       2) 被评为“武汉大学研究生十大学术之星”

       3) “武汉大学理学部第三届研究生学术报告比赛”一等奖

       4) 武汉大学第七届“自强杯”课外学术科技作品竞赛二等奖

2010年 武汉大学优秀研究生“蓝月亮专项奖学金”

2011年 武汉大学优秀研究生“蓝月亮专项奖学金”

2012年 武汉大学“优秀研究生学术创新奖”一等奖

2013年 武汉大学“优秀研究生学术创新奖“二等奖

代表性成果：

(1) Enzyme-InspiredChiral Secondary-Phosphine-Oxide Ligand with Dual Noncovalent Interactions forAsymmetric Hydrogenation. C. Chen, Z. Zhang, S. Jin, X. Fan, M. Geng, Y.Zhou, S. Wen, X. Wang, L. W. Chung,* X. Dong,* X. Zhang,* Angew.Chem., Int. Ed. 2017, 56, 6808-6812. (HighlightedinSynfacts 2017,13,934)

(2) Rh/SPO-WudaPhos-CatalyzedAsymmetric Hydrogenation of α-Substituted Ethenylphosphonic Acids viaNoncovalent Ion-Pair Interaction, X. Yin, C. Chen, X. Li, X. Dong*and X. Zhang, * Org. Lett. 2017, 19, 4375-4378.

(3) Highly Enantioselective AsymmetricHydrogenation of Carboxy-Directed a,a-Disubstituted Terminal Olefins via theIon Pair Noncovalent Interaction, S. Wen, C. Chen, S. Du, Z. Zhe, Y.Huang, Z. Han, X. Dong* and X. Zhang, * Org. Lett. 2017, 19, 6474-6477.

(4) Readily Accessible and HighlyEfficient Ferrocene-Based Amino-Phosphine-Alcohol (f-Amphol) Ligands forIridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones, J. Yu, M. Duan,W. Wu, X. Qi, P. Xue, Y. Lan, X. Dong,* X. Zhang,* Chem.-Eur.J. 2017, 23, 970-975.

(5) Iridium-Catalyzed Asymmetric Hydrogenationof Ketones with Accessible and Modular Ferrocene-Based Amino-phosphine Acid (f‑Ampha)Ligands, J. Yu, J. Long, Y. Yang, W. Wu, P. Xue, L. W. Chung,* X. Dong*and X. Zhang, * Org. Lett. 2017, 19,690-693.

(6) EnantioselectiveSynthesis of Chiral 3-Substituted-3-silylpropionic Esters viaRhodium/Bisphosphine-Thiourea-Catalyzed Asymmetric Hydrogenation, Z. Zhang,Z. Han, G. Gu, X. Dong* and X. Zhang,* Adv. Syn. Catal. 2017, 359, 2585-2589.

(7) Accessto Chiral Seven-Member Cyclic Amines via Rh-Catalyzed Asymmetric Hydrogenation,P. Li, Y. Huang, X. Hu, X. Dong* and X. Zhang,* Org.Lett. 2017, 19, 3855-3858.

(8) Rh/Wudaphos-CatalyzedAsymmetric Hydrogenation of Sodium α-Arylethenylsulfonates: A Method To AccessChiral α-Arylethylsulfonic Acids, X. Yin, C. Chen, X. Dong* andX. Zhang,* Org. Lett. 2017, 19, 2678-2681.

(9) Enantioselectiveand Diastereoselective Construction of Chiral Amino Alcohols byIridium-f-Amphox-Catalyzed Asymmetric Hydrogenation via Dynamic Kinetic Resolution,Wu, W. You, C. Yin, C. Liu, Y. X. Dong* and X. Zhang,* Org.Lett. 2017, 19, 2548-2551.

(10) Cobalt-catalyzed(Z)-selective semihydrogenation of alkynes with molecular hydrogen, C.Chen, Y. Huang, Z. Zhang, X. Dong* and X. Zhang,* Chem.Commun. 2017, 53, 4612-4615.

(11) Asymmetrichydrogenation of maleic anhydrides catalyzed by Rh/bisphosphine-thiourea:efficient construction of chiral succinic anhydrides, Z. Han, R. Wang, G.Gu, X. Dong* and X. Zhang,* Chem. Commun. 2017, 53, 4226-4229.

(12) Rhodium/Yanphos-Catalyzed AsymmetricInterrupted Intramolecular Hydroaminomethylation of trans-1,2-DisubstitutedAlkenes, C. Chen, S. Jin, Z. Zhang, B. Wei, H. Wang, K. Zhang, H. Lv,* X.Dong,* X. Zhang,* J. Am. Chem. Soc. 2016, 138,9017-9020. (Spotlights in J. Am. Chem. Soc.)

(13) Ferrocenyl chiral bisphosphorusligands for highly enantioselective asymmetric hydrogenation via noncovalention pair interaction, C. Chen, H. Wang, Z. Zhang, S. Jin, S. Wen, J. Ji, L. W.Chung, X. Dong,* X. Zhang,* Chem. Sci. 2016,7, 6669-6673. (Highlighted inSynfacts 2016,12,931).

(14) N-Heterocyclic CarbeneCatalyzed g-Dihalomethylenation of Enals by Single-Electron Transfer, W.Yang, W. Hu, X. Dong, X. Li, J. Sun,*Angew. Chem. Int. Ed. 2016, 55,15783-15786.

(15) Rhodium/bisphosphine-thiourea-catalyzedenantioselective hydrogenation of a,b-unsaturated N-acylpyrazoles, P. Li, X.Hu,* X. Dong,* X. Zhang,* Chem. Commun. 2016, 52,11677-11680. (Highlighted inSynfacts 2016,12,1169).

(16) Synthesis of Chiral β-Amino Nitroalkanesvia Rhodium-Catalyzed Asymmetric Hydrogenation, P. Li, M. Zhou, Q.Zhao, W. Wu, X. Hu,* X. Dong,* X. Zhang,* Org. Lett. 2016, 18,40-43. (Highlighted inSynfacts 2016,12,378).

(17) Iridium Catalysts with f‑AmphoxLigands: Asymmetric Hydrogenation of Simple Ketones, W. Wu, S. Liu, M.Duan, X. Tan, C. Chen, Y. Xie, Y. Lan,* X. Dong,* X. Zhang,* Org.Lett. 2016, 18, 2938-2941. (Highlighted inSynfacts 2016,12,938).

(18) Selective Rhodium-CatalyzedHydroformylation of Alkynes to α,β-Unsaturated Aldehydes with aTetraphosphoramidite Ligand, Z. Zhang, Q. Wang, C. Chen, Z. Han, X.Dong,* X. Zhang,* Org. Lett. 2016, 18,3290-3293. (Highlighted inSynfacts 2016,12,930).

(19) Highly Enantioselective Synthesis ofChiral Succinimides via Rh/Bisphosphine-Thiourea-CatalyzedAsymmetric Hydrogenation, Z. Han, P. Li, Z. Zhang, C. Chen, Q. Wang, X.Dong,* X. Zhang,* ACS Catal. 2016, 6,6214-6218. (Highlighted inSynfacts 2016,988).

(20) Rhodium-catalyzed asymmetrichydrogenation of unprotected β-enamine phosphonates, M. Zhou, Z. Xue, M.Cao, X. Dong,* X. Zhang*,Org. Biomol. Chem. 2016, 14,4582-4584. (Highlighted inSynfacts 2016,12,722).

(21) Chiral Ligands for Rhodium-CatalyzedAsymmetric Hydroformylation: A Personal Account, C. Chen, X. Dong,*X. Zhang*, Chem. Rec.2016, 16(6), 2670-2682.

(22) New synthetic strategy for chiral2-oxazolidinones derivatives via rhodium-catalyzed asymmetric hydrogenation, Q.Wang, X. Tan, Z. Zhu,X. Dong,* X Zhang,* Tetrahedron Letters, 2016, 57,658-662.

(23) N-Heterocyclic CarbeneCatalyzed Enantioselective α-Fluorination of Aliphatic Aldehydes and α-ChloroAldehydes: Synthesis of α-Fluoro Esters, Amides, and Thioesters, X.Dong, W. Yang, W. Hu, J. Sun,* Angew. Chem., Int. Ed. 2015, 54,660-663.

(24) Catalytic Asymmetric α-Aldol Reactionof Vinylogous N-Heterocyclic Carbene Enolates: Formation of Quaternary andLabile Tertiary Stereocenters, X. Dong, J. Sun,* Org. Lett., 2014, 16,2450-2453.

(25) Organocatalytic asymmetric dominosulfa-Michael-aldol reactions of 2-mercaptobenzaldehyde with a,b-unsaturated N-acylpyrazolesfor the construction of thiochromane, X. Dong, X. Fang, H.-Y. Tao,X. Zhou, C.-J. Wang,* Chem. Commun. 2012, 48, 7238-7240.

(26) Highly Efficient Catalytic AsymmetricSulfa-Michael Addition of Thiols to trans-4,4,4-Trifluorocrotonoylpyrazole, X.Dong, X. Fang, H.-Y. Tao, X. Zhou, C.-J. Wang,* Adv. Synth. Catal. 2012,354, 1141-1147.

(27) Organocatalytic Asymmetric Sulfa-MichaelAddition of Thiols to 4,4,4-Trifluorocrotonates, X. Dong, X. Fang,C.-J. Wang,* Org. Lett. 2011,13, 4426-4429.

(28) Organocatalytic asymmetric Michaeladdition of a-aryl cyclopentanones to nitroolefins for construction ofadjacent quaternary and tertiary stereocenters, X. Dong, H.-L.Teng, M.-C. Tong, H. Huang, H.-Y. Tao, C.-J. Wang,* Chem. Commun. 2010, 46,6840-6842.

(29) Highly Enantioselective Direct MichaelAddition of Nitrolalkanes to Nitroalkenes Catalyzed by Bifunctional ThioureaBearing Multiple Hydrogen Bonding Donors, X. Dong, H.-L. Teng,C.-J. Wang,* Org. Lett. 2009, 11,1265-1268.

(30) Highly anti-Selective AsymmetricNitro-Mannich Reactions Catalyzed by Bifunctional Amine-thiourea BearingMultiple Hydrogen Bonding Donors. C.-J. Wang,* X. Dong, Z.-H.Zhang, Z.-Y. Xue, H.-L. Teng, J. Am. Chem. Soc. 2008, 130,8606-8607. (Highlighted inSynfacts 2008,988).