中国科学院福建物质结构研究所宋玲

diu

宋玲，女，1973年生，博士，研究员。1994年获武汉大学环境化学专业学士学位；1997年获中国科学院福建物质结构研究所硕士学位；2004年获美国新墨西哥大学有机化学博士学位，从事有机小分子和天然产物全合成；之后在美国新墨西哥大学和伊利诺伊大学香槟分校做博士后，从事酶的催化功能的确认、催化反应动力学和催化机理的研究。2008年11月获中国科学院福建物质结构研究所“海外引进人才”基金资助，担任课题组长。在Nature Chemical Biology，Chemical Science, Org. Lett., J. Org. Chem. 等杂志上发表论文三十余篇。联系方式：E-mail: songling@fjirsm.ac.cn
研究方向
1. 新型手性配体和手性催化剂的设计合成和应用。
2. 手性分子之间的相互作用机制（手性大分子和手性小分子之间，手性小分子和手性小分子之间）。

期刊论文：
2017年：
1. Wang Y. B., Yang S. W., Bian G. L.*, Song L.* A novel three-step tandem reaction for efficient syntheses of bulky anthracenyl esters. synthesis, 2017, 49, 1884-88.
2016年：
1. Huayin Huang, Guangling Bian, Hua Zong, Yabai Wang, Shiwei Yang, Huifeng Yue, Ling Song* and Hongjun Fan*. Chiral Sensor for Enantiodiscrimination of Varied Acids. Org. Lett. 2016, 18, 2524−2527.
2. Guangling Bian, Shiwei Yang, Huayin Huang, Hua Zong and Ling Song*, A bisthiourea-based 1H NMR chiral sensor for chiral discrimination of a variety of chiral compounds. Sensors and Actuators B: Chemical, 2016, 231, 129-134.
3. Guangling Bian, Shiwei Yang, Huayin Huang, Hua Zong, Ling Song,* Hongjun Fan* and Xiaoqiang Sun*. Chirality sensing of tertiary alcohols by a novel strong hydrogenbonding donor-selenourea, Chemical Science, 2016, 7, 932-938.
4. Wang Y. B., Zong H., Huang H. Y.*, Song L.* Chiral thiophosphoramide catalyzed asymmetric aryl transfer reactions for the synthesis of functional diarylmethanols. Tetrahedron: Asymmetry, 2016, 28 , 90-97.
2015年：
1. Huayin Huang#, Hua Zong#, Guangling Bian, Ling Song*. Chemo- and Enantioselective Addition and β Hydrogen Transfer Reduction of Carbonyl Compounds with Diethylzinc Reagent in One Pot Catalyzed by a Single Chiral Organometallic Catalyst, J.Org.Chem., 2015, 80(24): 12614-12619. (This article was highlighted by SYNFACTS 2016, 12, 0190).
2. Huayin Huang, Hua Zong, Guangling Bian, and Ling Song*. Catalytic asymmetric b-hydrogen transfer reduction of a-trifluoromethyl aromatic ketones with diethylzinc, Tetrahedron Asymmetry, 2015, 26(15-16): 835-839.
3. Guangling Bian, Hongjun Fan, Huayin Huang, Shiwei Yang, Hua Zong, Ling Song*, and Genjin Yang*. Highly Effective Configurational Assignment Using Bisthioureas asChiral Solvating Agents in the Presence of DABCO. Org. Lett., 2015, 17 (6), pp 1369-1372.
4. Fangling Li, Huayin Huang, Hua Zong, Guangling Bian, Ling Song*. Investigation on the asymmetric addition reactions between varied nonaromatic aldehydes and diethylzinc catalyzed by chiral phosphoramide and thiophosphorodiamide ligands, Tetrahedron Letters, 2015, 56(16): 2071-2076
5. Yan Liu, Mingmao Chen, Ling Song*. Stereoselective interaction of cinchona alkaloid isomers with bovine serum albumin, Food Chem. 2015, 181, 170-178.
2014年：
1. Hua Zong, Huayin Huang, Guangling Bian and Ling Song*. Fine-Tuning the Structures of Chiral Diamine Ligands in the Catalytic Asymmetric Aldol Reactions of Trifluoromethyl Aromatic Ketones with Linear Aliphatic Ketones. J. Org. Chem. 2014, 79, 11768-11773.
2. Huayin Huang, Hua Zong, Guangling Bian, Huifeng Yue and Ling Song*. Correlating the Effects of the N-Substituent Sizes of Chiral 1,2-Amino Phosphinamide Ligands on Enantioselectivities in Catalytic Asymmetric Henry Reaction Using Physical Steric Parameters. J. Org. Chem., 2014, 79, 9455–9464.
3. Yan Liu, Mingmao Chen, Shuaihua Wang, Jingjing Lin, Lizhen Cai, Ling Song*. New insight into the stereoselective interactions of quinine and quinidine, with bovine serum albumin. Journal of molecular recognition, 2014, 27 (5), 239.
4. Yan Liu, Mingmao Chen, Longguang Jiang, Ling Song*. New insight into molecular interaction of heavy metal pollutant-cadmium(II) with human serum albumin. Environmental Science and Pollution Research, 2014, 21(11), 6994-7005.
5. Huifeng Yue, Huayin Huang, Guangling Bian, Hua Zong, Fangling Li and Ling Song*. Enantioselectivity switch controlled by N,N’-di- or N,N,N’,N’- tetra-substituted chiral thiophosphorodiamide ligands, structural relatives of thioureas, in catalytic additions of diethylzinc to aldehydes. Tetrahedron Asymmetry, 2014, 25, 170-180.
6. Huayin Huang, Hua Zong, Bin Shen, Huifeng Yue, Guangling Bian and Ling Song*. QSAR Analysis of the Catalytic Asymmetric Ethylation of Ketone Using Physical Steric Parameters of Chiral Ligand Substituents. Tetrahedron, 2014, 70, 1289-1297.
7. Jingjing Lin, Yan Liu*, Mingmao Chen, Huayin Huang and Ling Song*. Investigation on the binding activities of citalopram with human and bovine serum albumins. Journal of Luminescence, 2014, 146, 114-122.
2013年：
1. Guangling Bian, Hongjun Fan, Shiwei Yang, Huifeng Yang, Huayin Huang, Hua Zong and Ling Song*. A Chiral Bisthiourea as a Chiral Solvating Agent for Carboxylic Acids in the Presence of DMAP. J. Org. Chem., 2013, 78, 9137-9142.
2. Yan Liu; Jingjing Lin, Mingmao Chen and Ling Song*. Investigation on the interaction of the toxicant, gentian violet, with bovine hemoglobin. Food and Chemical Toxicology, 2013, 58, 264-272.
3. Jingjing Lin, Yan Liu*, Lingrong Liu and Ling Song*. Studies on the Toxic Interaction Mechanism between 2-Naphthylamine and Herring Sperm DNA. Journal of Biochemical and Molecular Toxicology, 2013, 27, 279-285.
4. Hua Zong, Huayin Huang, Guangling Bian and Ling Song*. Synergistic Effect of Achiral Quaternary Ammonium Salt on Asymmetric Additions of Diethylzinc to Aldehydes. Tetrahedron Lett., 2013, 54, 2722-2725. (This article was highlighted by SYNFACTS 2013, 8, 873).
5. Bin Shen, Huayin Huang, Guangling Bian, Hua Zong and Ling Song*. Highly Efficient Asymmetric Additions of Diethylzinc to Aldehydes Triply Activated by Chiral Phosphoramide-Zn(II) Complexes Derived from Cinchona Alkaloids. Chirality, 2013, 25, 561-566.
6. Guangling Bian, Shiwei Yang, Huayin Huang and Ling Song*. A New Method for the Synthesis of Enantiomerically Pure Betti Base. Synthesis-Stuttgart, 2013, 45, 0899-0902.
7. Yan Liu , Mingmao Chen , Zhipu Luo , Jingjing Lin and Ling Song*. Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride. Journal of Biomolecular Structure & Dynamics, 2013, 31, 1160-1174.
8. Yan Liu, Mingmao Chen and Ling Song*. Comparing the effects of Fe(III) and Cu(II) on the binding affinity of erlotinib to bovine serum albumin using spectroscopic methods. Journal of Luminescence, 2013, 134, 515-523.
2012年：
1. Huayin Huang, Hua Zong, Guangling Bian and Ling Song*. Constructing a Quantitative Correlation between N-Substituent sizes of Chiral Ligands and Enantioselectivities in Asymmetric Addition Reactions of Diethylzinc with Benzaldehyde. J. Org. Chem., 2012, 77, 10427-10434.
2. Guangling Bian, Huayin Huang, Hua Zong and Ling Song*. The syntheses of new camphorsulfonylated ligands derivedfrom 2-amino-2’-hydroxy-1, 1’-binaphthyl and their enantioselectivities in the addition of dialkylzinc reagents to aldehydes. Chirality, 2012, 24, 825-932.
3. Hua Zong, Huayin Huang, Junfeng Liu, Guangling Bian and Ling Song*. Added-Metal-Free Catalytic Nucleophilic Addition of Grignard Reagents to Ketones. J. Org. Chem., 2012, 77, 4645-4652.
4. Junfeng Liu, Jin Lin and Ling Song*. Efficient catalytic transition-metal-free conditions for nucleophilic addition of phenylacetylene to aromatic ketones. Tetrahedron Letters, 2012, 53, 2160–2163.
2011年：
1. Yan Liu, Mingmao Chen, Guangling Bian, Junfeng Liu and Ling Song*. Spectroscopic investigation of the interaction of the toxicant, 2-naphthylamine, with bovine serum albumin. Journal of Biochemical and molecular toxicology, 2011, 25, 362-368.
2. Huayin Huang, Hua Zong, Guangling Bian, Xiaoqiang Sun and Ling Song*. Synthesis of L-valine Derivative Ligands and Their Application in Enantioselective Addition of Diethylzinc to Benzaldehyde. Chinese Journal of Synthetic Chemistry, 2011, 19, 295-298.
3. Hua Zong, Huayin Huang, Guangling Bian, Yixin Leng and Ling Song*. Synthesis and characterization of novel sulfonamide chiral ligands. Chinese Journal of Chemical Reagents, 2011, 33,773-776.
4. Hua Zong, Huayin Huang, Bing Hu, Guangling Bian and Ling Song*. 2,2'-Bis(methoxymethoxy)-3,3'-diphenyl-1,1'binaphthalene. Acta Cryst. 2011, E67, o222.
2010年之前：
1. Ling Song, Kalyanaraman C, Fedorov A, Fedorov E, Glasner M, Brown S, Imker H, Babbitt P, Almo S, Jacobson M and Gerlt JA; Prediction and assignment of function for a divergent N-succinyl amino acid racemase. Nature Chemical Biology, 2007, 3, 486-491.
2. Ling Song, Duesler EN and Mariano PS; Stereoselective Synthesis of Polyhydroxylated Indolizidines Based on Pyridinium Salt Photochemistry and Ring Rearrangement Metathesis. J. Org. Chem., 2004, 69, 7284-7293.