厦门大学化学化工学院化学生物学系赵玉芬

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赵玉芬

教授、博士生导师
电话：（0592）2185780（实验室）
　　　（0592）2185610（办公室）
传真：（0592）2186292
电子邮箱：yfzhao@xmu.edu.cn
实验室主页(Prof. Yufen Zhao Group Website)

个人简历：
博士（美国纽约州立大学石溪分校，1975）学士（台湾清华大学）
博士后（美国纽约州立大学石溪分校）
中国科学院院士
先后获得国际阿布佐夫奖，中科院科技进步二、三等奖，教育部科技进步二、三等奖，中国青年科学家奖，第二届新世纪巾帼发明家等。

研究兴趣：
生命有机化学，有机磷化学，生命起源，药物化学，化学生物学

近期主要代表论著：

• “A universal and multiplex kinase assay using γ-[18O4]-ATP”，Fu, Chuan; Zheng, Xueyun; Jiang, Yao; Liu, Yan; Xu, Pengxiang;     Zeng, Zhiping; Liu, Rihe; Zhao, Yufen， Chemical     Communications (2013), 49(27), 2795-2797.
  
• “Copper-Catalyzed Synthesis of α-Hydroxy Phosphonates from     H-Phosphonates and Alcohols or Ethers”，Zhao, Zengxiang; Xue, Wanhua; Gao, Yuxing; Tang, Guo; Zhao,     Yufen，Chemistry--An Asian Journal (2013), 8(4), 713-716.
  
• “Nickel(II)-magnesium-catalyzed cross-coupling of     1,1-dibromo-1-alkenes with diphenylphosphine oxide: one-pot synthesis of     (E)-1-alkenylphosphine oxides or bisphosphine oxides”，Liu, Liu; Wang, Yulei; Zeng, Zhiping; Xu, Pengxiang; Gao,     Yuxing; Yin, Yingwu; Zhao, Yufen，Advanced     Synthesis & Catalysis (2013), 355(4), 659-666.
  
• “Stable Isotope N-Phosphorylation Labeling for Peptide de Novo     Sequencing and Protein Quantification Based on Organic Phosphorus     Chemistry”，Gao, Xiang; Wu, Hanzhi; Lee, Kim-Chung; Liu, Hongxia; Zhao,     Yufen; Cai, Zongwei; Jiang, Yuyang，Analytical     Chemistry (2012), 84(23), 10236-10244.
  
• “Suppression of matrix ions by N-phosphorylation labeling using     matrix-assisted laser desorption-ionization time-of-flight mass     spectrometry”，Gao, Xiang;     Tang, Zhi; Lu, Minghua; Liu, Hongxia; Jiang, Yuyang; Zhao, Yufen; Cai,     Zongwei，Chemical Communications (2012), 48(82), 10198-10200.
  
• “An isotope (18O, 15N, and 2H) technique to investigate the     metal ion interactions between the phosphoryl group and amino acid side     chains by electrospray ionization mass spectrometry”，Gao, Xiang; Hu, Xiaomei; Zhu, Jun; Zeng, Zhiping; Han, Daxiong;     Tang, Guo; Huang, Xiantong; Xu, Pengxiang; Zhao, Yufen，Journal of the American Society for Mass Spectrometry (2011),     22(4), 689-702.
  
• “Fast separation of antiviral nucleoside phosphoramidate and     H-phosphonate diastereoisomers by reversed-phase liquid chromatography”， Gao, Xiang; Chen, Weizhu; Zhu, Gangtian; Yi, Ruizao; Wu,     Zhen; Xu, Pengxiang; Zhao, Yufen，Journal of     Chromatography, A (2011), 1218(10), 1416-1422.
  
• “Intermolecular phosphoryl transfer of N-phosphoryl amino acids”，Gao, Xiang; Deng, Honggui; Tang, Guo; Liu, Yan; Xu, Pengxiang;     Zhao, Yufen，European Journal of Organic Chemistry (2011), (17), 3220-3228
  
• “Stereospecific Coupling of H-Phosphinates and Secondary     Phosphine Oxides with Amines and Alcohols: A General Method for the     Preparation of Optically Active Organophosphorus Acid Derivatives”, G.     Wang, R.-W. Shen, Q. Xu, Goto Midori, Y.-F. Zhao and L.-B. Han, J. Org.     Chem. 2010, 75, 3890–3892
  
• “Selective P-P and P-O-P Bond Formations through     Copper-Catalyzed Aerobic Oxidative Dehydrogenative Couplings of     H-Phosphonates”, Y.-B. Zhou, S.-F. Yin, Y.-X. Gao, Y.-F. Zhao, Midori     Goto, and L.-B. Han, Angew. Chem. Int. Ed,., 2010, 49, 6852 –6855
  
• “Genome wide exploration of the origin and evolution of amino     acids”, X.-X. Liu, J.-X. Zhang, F. Ni, X. Dong, B.-C. Han, D.-X. Han,     Z.-L. Ji, Y.-F. Zhao, BMC Evolutionary Biology, 2010, 10:77
  
• “Copper-Catalyzed Aerobic Oxidative Coupling of Terminal     Alkynes with H-Phosphonates Leading to Alkynylphosphonates”, Y.-X. Gao, G.     Wang, L. Chen, P.-X. Xu, Y.-F. Zhao, Y.-B. Zhou, and L.-B. Han, J. Am.     Chem. Soc., 2009, 131, 7956–7957
  
• “N-phosphorylation of amino acids by trimetaphosphate in     aqueous solution—learning from prebiotic synthesis”, F. Ni, S.-T. Sun, C.     Huang and Y.-F. Zhao, Green Chemistry, 2009, 11, 569 – 573
  
• “On the Electrophilicity of cyclic acylphosphoramidates (CAPAs)     postulated as intermediates”, F. Ni, X. Gao, Z.-X. Zhao, C. Huang, and     Y.-F. Zhao, Eur. J. Org. Chem., 2009, 3026–3035.
  
• “Chirality at phosphorus in pentacoordinate spirophosphoranes:     stereochemistry by X-ray structure and spectroscopic analysis”, J.-B. Hou,     H. Zhang, J.-N. Guo, Y. Liu, P.-X. Xu, Y.-F. Zhao and G. M. Blackburn,     Org. Biomol. Chem., 2009, 7, 3020–3023.
  
• “Negative ion electrospray ionization mass spectrometry of     nucleoside phosphoramidate monoesters: elucidation of novel rearrangement     mechanisms by multistage mass spectrometry incorporating in-source     deuterium labeling”, P.-X. Xu, A.-F. Hu, D. Hu, X. Gao, Y.-F. Zhao, Rapid     Communications in Mass Spectrometry, 2008, 2 :19, 2977-2983
  
• “Alpha-amino acid behaves differently from beta- or gamma-amino     acids as treated by trimetaphosphate”, X. Gao, Y. Liu, P.-X. Xu, Y.-F.     Zhao. Amino Acids., 2008, 34, 47-53.
  
• “DNA cleavage function of seryl-histidine dipeptide and its application”,     Y. Ma, X. Chen, M. Sun, R. Wan, C.-J. Zhu, Y.-M. Li, Y.-F. Zhao, Amino     Acids., 2008, 35, 251-256.
  
• “Analysis of the phosphoryl transfer mechanism of c-amp     dependent protein kinase (pka) by penta-coodinate phosphoric transition     state theory”, F. Ni, W. Li, Y. Li, Y.-F. Zhao, Current Protein &     Peptide Science, 2005, 6, 437-442.
  

yatui

5月17日，中国科学院院士、著名有机化学家赵玉芬教授应邀来武夷学院，作《磷与生命起源》专题学术报告。校党委肖铮书记主持报告会，并与生态与资源工程学院师生一起聆听了赵院士的报告。

报告会上，赵院士以生命起源为开题，详细介绍了磷在生命中的重要作用，磷化学在生命科学以及在化学合成中的研究进展，以及在磷化学方向的大量研究成果。深入浅出地阐述了磷和生命起源的内在关系，并以生动的故事分享了她的实验探索和科研经历。报告会结束后，赵院士还与师生进行了互动交流。

赵玉芬院士是我国著名有机化学家、生命科学界的权威之一，创建了“磷酰化氨基酸是蛋白质和核酸的共同起源”的新的理论体系，这一解释生命起源的新成果已经被世界生命化学界广为引用，推动了世界磷化学和生命化学的进步。

赵玉芬院士十分关心我校的发展，多次莅临学校指导工作，并在我校竹材工程中心设立院士工作站，带领团队推进竹纤维复合材料和生物营养源等系列项目的开发，致力于服务竹生态产业绿色发展，极大地提升了我校科技创新水平和服务产业能力。