上海大学理学院龚和贵

zhongyuzhuan

龚和贵，博士，上海大学教授、博士生导师，上海市高校特聘教授（东方学者）。1995年获得郑州轻工业学院精细化工学士学位，1998年获得清华大学有机化学硕士学位，2005年获得美国University of Texas at Austin化学博士学位。2005至2008年，在美国University of North Carolina at Chapel Hill化学系从事博士后研究，并获该校优秀博士后奖。


姓名        龚和贵
职称/职务        教授
电话/传真        86-21-66132410
电子邮箱        hegui_gong@shu.edu.cn
个人主页        www.hgonggrp.shu.edu.cn
学科/专业        化学/有机超分子化学
主要研究领域        有机超分子材料和金属催化的亲电试剂直接偶联化学
学术/社会兼职         
主要获奖         
主要课程教学         
主要学术成果        1. Supramolecular Materials
Design of robust H-bonds in water is a fundamentally challenging task in supramolecular studies. On the other hand, the pivotal roles of non-covalent bonding, particularly H-bonding in the determination of higher-order structures of natural biopolymers, e.g. DNA double helix, have spurred tremendous studies on the assembly of synthetic molecular strands towards well-defined supramolecular materials. This knowledge base prompts us to design ion-pair-assisted H-bonding building units with high binding affinities in water. Decoration of molecular strands with the ionic H-bond precursors leads to ionic strands capable of self-organizing into various supramolecular complexes such as polymers and nanotubes. Functionalization of the molecular strands could ultimately lead to functional materials.


2. Supramolecular Catalysis


A second focal point concerns the development of novel catalysts utilizing a non-covalent bonding strategy. Analogous to catalysts arising form metal-ligand complexation, we proposed a concept of supramolecular catalysts deriving from the assembly of chiral scaffolds and achiral organocatalysts. The goal of this protocol is to provide efficient access to a library of catalytic systems and facilitate the studies of novel orgaocatalytic methodologies.


3. Organo, Metal Catalysts and Organo-Metal Co-catalysis


Small organic molecules and transition metal-mediated catalysis have become the major research themes in modern organic synthetic chemistry. Our interests in this broad area consist of the development of new organo-catalysts, transition metal-catalyzed non-classical cross-couplings and asymmetric catalysis involving organo- and metal-catalysts. We target solutions for challenging issues residing in modern organic synthesis. The ongoing projects include the development of silanol-based H-bond-donor catalysts, Transition metal-catalyzed cross-coupling of two electrophiles, and asymmetric radical reactions catalyzed by metal-organo co-catalysts.
代表性论著        (1) Yu, X.; Dai, Y.; Yang, T.; Gagné, M. R.; Gong, H.* "Facile Synthesis of Salmochelin S1, S2, MGE, DGE and TGE". Tetrahedron 2011, 67, 144-151
(2) Yu, X.; Yang, T.; Wang S.; Xu H.; Gong, H.* "Nickel-Catalyzed Reductive Cross-Coupling of Unactivated Alkyl Halides". Org. Lett. 2011, 13, 2138-2141
(3) Dai, Y.; Wu, F.; Zang, Z.; You, H.; Gong, H.* "Ni-Catalyzed Reductive Allylation of Unactivated Alkyl Halides with Allylic Carbonates". Chem. Eur. J. 2012, 18, 808
(4) Wu, F.; Lu, W.; Qian, Q.; Ren, Q.; Gong, H.* "Ketone Formation via Mild Nickel-Catalyzed Reductive Coupling of Alkyl Halides with Aryl Acid Chlorides", Org. Lett. 2012, 14, ASAP
(5) Yin, H.; Zhao, C.; You, H.; Lin, K.; Gong, H.* "Mild Ketone Formation via Ni-Catalyzed Reductive Coupling of Unactivated Alkyl Halides with Acid Anhydrides", Chem. Commun. 2012, In Press.
(6) Gong, H.; Krische, M. J. "H-bond Directed Self-assembly of Oligomeric Molecular Strands Incorporating Aminopyrazolone Moieties," Angew. Chem. Int. Ed. 2005, 44, 7069-7071 (Highlighted as VIP: very important paper)
（7）Jang, H.-Y.; Hughes, F.; Gong, H.; Zhang, J.; Brodbelt, J. S.; Krische, M. J. "Hydrogen-Mediated C-C Bond Formation: Enantioselective Reductive Cyclization of 1,6-Enynes via Rhodium Catalyzed Asymmetric Hydrogenation," J. Am. Chem. Soc. 2005, 127, 6174-6175
（8）Gong, H.; Krische, M. J. "Duplex Molecular Strands Based on the 3,6-Diaminopyridazine Hydrogen Bonding Motif: Amplifying Small Molecule Self-Assembly Preferences through Preorganization and Iteration," J. Am. Chem. Soc. 2005, 127, 1719-1725
（9）Gong, H.; Sinisi, R.; Gagné, M. R. "A Room Temperature Negishi Cross-Coupling Approach to C-Alkyl Glycosides". J. Am. Chem. Soc. 2007, 129, 1908-1909
（10）Gong, H.; Gagné, M. R. "A Diastereoselective Ni-Catalyzed Negishi Cross-Coupling Approach to Saturated, Fully Oxygenated C-Alkyl and C-Aryl Glycosides". J. Am. Chem. Soc. 2008, 130, 12177-12183
（11）Gong, H.; R. Anderw, R. S.; Zuccarello, J. L.; Lee, S. J.; Gagné, M. R. "Sn-Free Ni-Catalyzed Reductive Coupling of Glycosyl Bromides with Activated Alkenes". Org. Lett. 2009, 11, 879-892