广西师范大学化学与药学学院无机化学梁宏

huyou

梁宏，广西师范大学教授。任职广西科协副主席，省部共建药用资源化学与药物分子工程国家重点实验室主任，广西师范大学博士生导师，兼任南开大学、南京大学无机化学博士生导师和中南大学应用化学博士生导师。研究成果主要发表在Nature Communications、Angew Chem Int Ed、Molecular Pharmaceutics、Journal of Medicinal Chemistry、Eur Chem J、Chem Comm和《中国科学》等国内外权威期刊300余篇, 并被国内外学者在SCI期刊引用约3000次；多次获得广西科技进步一等奖和广西自然科学一等奖；授权20项国家发明专利。


梁宏
联系方式
办公电话：(0773)5846185
手机号码
电子邮箱：hliang@mailbox.gxnu.edu.cn
办公地址：

研究方向
新型抗肿瘤金属药物和载药体系：
1）细胞迁移机制
2）基于DNA和蛋白质设计新型抗肿瘤金属药物
3） 蛋白质和纳米载药体系
社会任职
中国化学会理事
广西化学化工学会理事长
Curr Pharm Des 客座主编
国际刊物《Biomedical Materials》编委
《无机化学学报》（SCI-E期刊）编委
美国科学促进会（AAAS）特邀国际会员
Chemical review、Mol Pharm、J Med Chem、Eur J Med Chem、J Inorg Biochem 等国际权威期刊审稿人
讲授课程
生物无机化学
论著专利
近3年代表性论文：
1. Yue JP, Zhang Y, Liang WG, Gou XW, Lee P, Liu H, Lyv WQ, Tang WJ, Yang F*, Liang H*, Wu XY*. In Vivo Epidermal Migration Requires Focal Adhesion Targeting of ACF7. Nature Communications. 2016, 7:11692. (综合性顶级期刊)
2. YL Ma, JP Yue, Y Zhang, CZ Shi, M Odenwald, WG Liang, Q Wei, A Goel, XW Gou, J Zhang, SY Chen, WJ Tang, JR Turner, F Yang*, H Liang*, HL Qin*, XY Wu*. ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nature Communications. 2017, 8: 15375.
3. Chen ZF*, Qin QP, Qin JL, Liu YC, Huang KB, Li YL, Meng T, Zhang GH, Peng Y, Luo XJ, Liang H*. Stabilization of G-quadruplex DNA, inhibition of telomerase activity, and tumor cell apoptosis by organoplatinum(II) complexes with oxoisoaporphine. J Med Chem. 2015; 58: 2159-2179. (药物化学顶级期刊）
4. Chen ZF*, Qin QP, Qin JL, Zhou J, Li YL, Li N, Liu YC, Liang H*. Water-soluble ruthenium(II) complexes with chiral 4-(2,3-Dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilization of G-Quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis. J Med Chem. 2015; 58: 4771-4789.
5. Gou Y, Qi JX, Zhang Y, Jiang M, Zhou ZP, Wu XY, Yang F*, Liang H*. Developing anticancer copper(II) pro-drugs based on the nature of cancer cells and human serum albumin carrier IIA subdomain. Molecular Pharmaceutics. 2015, 12: 3597-3609. (药剂学顶级期刊)
6. Y Gou, Y Zhang, ZL Zhang, J Wang, ZP Zhou, F Yang*, H Liang*. Design of an anticancer copper(II) pro-drug based on the Lys199 residue of the active targeting human serum albumin nanoparticle carrier. Molecular Pharmaceutics. 2017, 14: 1861-1873.
7. Qi JX, Zhang Y, Gou Y, Zhang ZL, Zhou ZP, Wu XY, Yang F*, Liang H*. Developing an anti-cancer copper(II) pro-drug based on the His242 residue of the human serum albumin carrier IIA sub-domain. Molecular Pharmaceutics. 2016, 13: 1501−1507.
8. Qi JX, Gou Y, Zhang Y, XY Wu, Yang F*, H Liang*. HSA-based multi-drug delivery systems for combination therapy of three anticancer agents. Molecular Pharmaceutics. 2016, 13: 3098-105.
9. Yang F, Yue J, Ma L, Ma Z, Li M, Wu X, Liang H*. Interactive associations of drug-drug and drug-drug-drug with IIA sub-domain of human serum albumin. Molecular Pharmaceutics. 2012, 9: 3259-65.
10.Jiang BP, Zhou B, Shen XC*, Yu YX, Ji SC, Wen CC, Liang H*. Selective Probing of Gaseous Ammonia Using Red-Emitting Carbon Dots Based on an Interfacial Response Mechanism. Eur Chem J. 2015, 21:18993-9.
综述:
1. Designing pro-drugs based on special residues of human serum albumin. Curr Top Med Chem. 2016, 16: 996-1008. (医学SCI 2区)
2. Alkaloid-metal based anticancer agents. Curr Top Med Chem, 2013,13: 2104-2115.
3. Evaluation of interactions between platinum-/ruthenium-based anticancer agents and human serum albumin: Development of HSA carrier for metal-based drugs. Curr Pharm Design. 2015, 21: 1848-61. (医学SCI 2区)
专题评论 (Editorial Article):
1. HSA-based anti-inflammatory therapy: a new and improved approach. Future Med Chem. 2014, 6: 119-21. (医学SCI 2区)
2. HSA IIA subdomain-based developing anticancer metal pro-drug: a new and improved approach. Future Med Chem. 2016, 8: 89-91.
3. HSA-based drug development and drug delivery systems. Curr Pharm Design. 2016, 21: 1784. (医学SCI 2区)
科研项目
(1)广西院士后备培养人选 (2017.1-2021.12)
(2)国家自然科学基金-重点项目(21431001): 基于中药活性成分金属抗肿瘤配合物研究 (2015.1-2019.12)
(3)教育部创新团队：天然活性物质的发现、结构改造与功能
(4) 国家自然科学基金(21171043): 抗肿瘤先导植物药、金属基药物与人血清白蛋白相互作用研究 (2012.1-2015.12)
获奖情况
国家“百千万人才工程”领军人才（2016）
英国皇家化学会会士（2015）
中国青年科技奖（2001）
国家有突出贡献的中青年专家（1999）
“广西十百##才工程”第一层次人选（1998）
国家“百千万人才工程”人选 （1996）
国务院政府特殊津贴（1996）