中国科学院上海硅酸盐研究所吴成铁

fuli

吴成铁,中国科学院上海硅酸盐研究所博士生导师、中科院百人计划、德国洪堡学者、上海市优秀学科带头人和上海市浦江人才计划获得者，科技部863重点项目负责人。澳大利亚生物材料与组织工程协会会员、中国医师协会骨科再生医学工作组副主席、中国生物医学工程学会组织工程与再生医学分会委员、中国生物医学工程协会青年工作委员会委员、中国生物材料协会会员、中国生物医学工程协会会员。学术期刊“Applied Materials Today” 与 “Biomedical Glasses”副主编，“Acta Biomaterialia” “Progress in Natural Science: Materials International”, “Bioactive Materials”等杂志编委；澳大利亚国立健康医学研究司（NHMRC）项目评审专家。2006年初博士毕业于中科院上海硅酸盐研究所后，先后在澳大利亚悉尼大学、昆士兰科技大学及德国德累斯顿工业大学从事研究工作6年。主要从事介孔生物活性材料与硅基生物活性陶瓷用于硬组织修复材料的研究。2011年底获得中国科学院上海硅酸盐研究所海外杰出人才（中科院百人计划）引进，应聘回国从事科研工作。在国外先后主持并完成了瑞士“International Team for Implantology (ITI) Foundation”、德国洪堡委员会、澳大利亚ARC、悉尼大学及昆士兰科技大学等资助的科研项目。并获得德国洪堡研究员、澳大利亚ARC研究员（APDI）、悉尼大学研究员及昆士兰科技大学研究员等四个荣誉研究员（Fellowship）。主编CRC英文专著《Advanced bioactive inorganic materials for bone regeneration and drug delivery》一部，并参与撰写6本英文专著的章节。在生物材料相关领域发表SCI 期刊论文150多篇（第一作者60多篇, 通讯作者70多篇），主要包括Mater Today, Adv Funct Mater （2篇）, Biomaterials（17篇），J Control Release, Nanoscale（3篇）J Mater Chem (共19篇)，Acta Biomater (共26篇), Adv Mater Interface, Small, ACS Appl Mater& Interface, Bone, Tissue Eng, J R Soc Interface, Chem Asian J, J Biomed Mater Res A，Biomater Sci等。论文共被SCI引用3800余次，h指数37。共申请专利16项，获5项中国专利及2项美国专利（PCT）授权，其中2项中国专利与1项美国专利已经转让公司。


姓 名:吴成铁        
性    别:男
专家类别:研究员；百人；浦江人才        
学 历:工学博士
电 话:021-5241249        
传 真:021-52412249
电子邮件:chengtiewu@mail.sic.ac.cn        
个人主页:无
邮政编码:200050        
通讯地址:上海市长宁区定西路1295号        

研究领域：
　　生物活性陶瓷及纳米介孔生物活性玻璃用于骨组织工程、药物/蛋白传输与肿瘤治疗
　　3D打印等先进制备技术构建新型骨组织工程支架
　　生物活性材料与组织细胞（成骨、牙周、牙髓细胞及内皮细胞）的相互作用关系（免疫成骨、成血管化）
　　“热烈欢迎对生物材料研究有兴趣的学生报考研究生”
目前主持的项目：
　　科技部863重点项目
　　国家自然基金面上项目
　　上海市优秀学科带头人项目
　　中科院前沿局优秀青年拔尖人才项目
　　中国科学院人才创新项目
　　中国科学院-昆士兰州联合项目
参与的项目：
　　科技部十三五生物材料基因组计划
　　国家自然基金重大项目
　　高性能陶瓷及超微结构国家重点实验室开放课题
主持结题的项目：
　　国家自然基金青年项目
　　上海市“浦江人才计划”项目
　　上海市自然基金面上项目
　　中科院上海硅酸盐研究所创新重点培养项目
所获奖励：
　　1. 2016年上海长宁区十大杰出青年奖；
　　2. 2016年中科院上海分院杰出青年奖；
　　3. 2016年中国生物材料学会优秀青年科学家奖；
　　4. 2015年上海市优秀学科带头人计划奖；
　　5. 2015年英国皇家化学会“Journal of Materials Chemistry Lectureship”奖；
　　6. 2015年上海市优秀归侨奖；
　　7. 2013年上海市青年五四奖章；
　　8.
　　9. 2012年中国科学院百人计划；
　　10. 2012年上海市浦江人才计划；
　　11. 2011年德国洪堡洪堡学者；
　　12. 2009年澳大利亚研究司ARC-APDI博士后奖学金；
　　13. 2009年澳大利亚昆士兰科技大学校长博士后Fellowship；
　　14.   2007年澳大利亚悉尼大学校长博士后Fellowship。
近来发表的代表性专著及期刊论文：
专著  
　　1.Chengtie Wu, Jiang Chang, Yin Xiao. Book “Advanced bioactive inorganic materials for bone regeneration and drug delivery”, CRC publisher. 2013.
　　2.Chengtie Wu, Yin Xiao. “Mesoporous bioglass/silk composite scaffolds for bone tissue engineering”. In Book: “Biomaterials” ISBN 978-953-307-418-4, by editors: Rosario Pignatello. Publishers: Intech, 2011. P269-286.  
　　3.Chengtie Wu, Jiang Chang, Hala Zreiqat. “Engineered Ca-Si based ceramics for skeletal tissue reconstruction”. In Book: "Biomaterials for Bone Regenerative Medicine" by editors: N.Sooraj Hussain and J. D. Santos. Publishers: Trans Tech Publishers (Ttp), Switzerland, 2010. P121-150.
　　4.Yongxiang Luo, Chengtie Wu, Jiang Chang. “Inorganic nanomaterials for bone tissue engineering” In Book “Biomedical Nanomaterials”，by editors: Youqing Shen and Liangyu Zhao, Wiley 2015.
　　5.Mengchao Shi, Jiang Chang, Chengtie Wu. “Biomedical glasses: advancing from micro to nano and its potential application.” In Book:  “Bioglasses: from bone regeneration to cancer treatment”, by editors: Juliana Marchi, Springer-Verlag, 2016.
代表性期刊论文发表 （*通讯作者）
　　1.Hongshi Ma, Chuan Jiang, Dong Zhai, Yongxiang Luo, Yu Chen, Fang Lv, Zhengfang Yi, Yuan Deng, Jinwu Wang, Jiang Chang,* Chengtie Wu*. A bifunctional biomaterial with photothermal effect for tumor therapy and bone regeneration. Advanced Functional Materials 26:1197-1208 (2016)
　　2.Zetao Chen, Travis Klein, Rachael Z Murray, Ross Crawford, Jiang Chang, Chengtie Wu*, Yin Xiao*. Osteoimmunomodulation for the development of advanced bone biomaterials. Materials Today 19(6):304-321 (2016)
　　3.Yan Wu, Shouan Zhu, Chengtie Wu*, Ping Lu, Changchang Hu, Si Xiong, Jiang Chang, Boon Chin Heng, Yin Xiao, Hong Wei Ouyang*. A bi-lineage conducive scaffold for osteochondral defect regeneration. Advanced Functional Materials 24(28):4473-4483 (2014)
　　4.Fangfang Wang, Dong Zhai, Chengtie Wu*, Jiang Chang*. Multifunctional mesoporous bioactive glass/UCNPs nanocomposites with strong red emission for monitoring drug delivery and stimulating osteogenic differentiation of stem cells. Nano Research 9(4):1193-1208 (2016)
　　5.Chengtie Wu,* Jiang Chang.* Multifunctional mesoporous bioactive glasses for effective delivery of therapeutic ions and drug/growth factors. Journal of Controlled Release 193:282-295 (2014).
　　6.Hong Li, Chengtie Wu*, Jiang Chang, Yunshen Ge, Shiyi Chen*. Functional polyethylene terephthalate with nano-sized bioactive glass coatings stimulating in vitro and in vivo osseointegration for anterior cruciate ligament reconstruction. Advanced Materials Interfaces 1:140027-140036 (2014)
　　7.Hongshi Ma, Jian Luo, Zhe Sun, Lunguo Xia, Mengchao Shi, Mingyao Liu, Jiang Chang, Chengtie Wu*. 3D Printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration. Biomaterials In Press (2016)
　　8.Chengtie Wu,* Zetao Chen, Qianju Wu, Deliang Yi, Thor Friis, Xuebin Zheng, Jiang Chang, Xinquan Jiang*, Yin Xiao*. Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration. Biomaterials 71;35-47 (2015)
　　9.Zetao Chen, Jones Yuen, Ross Crawford, Jiang Chang, Chengtie Wu*, Yin Xiao*. The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalcium phosphate. Biomaterials. 61: 126-138 (2015).
　　10.Zetao Chen, Chengtie Wu*, Wenyi Gu, Travis Klein, Ross Crawford, Yin Xiao*. Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials 35(5):1507-18 (2014)
　　11.Chengtie Wu, Yinghong Zhou, Mengchi Xu, Pingping Han, Lei Chen, Jiang Chang*, Yin Xiao*. Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity. Biomaterials 34(2):422-433 (2013).
　　12.Chengtie Wu*, Yinghong Zhou, Wei Fan, Pingping Han, Jiang Chang, Jones Yuen, Meili Zhang, Yin Xiao.* Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterials 33(7):2076-2085 (2012)
　　13.Pingping Han, Chengtie Wu*, Jiang Chang, Yin Xiao*. The cementogenic differentiation of periodontal ligament cells via the activation of Wnt/β-catenin signalling pathway by Li+ ions released from bioactive scaffolds. Biomaterials 33(27):6370-6379 (2012)
　　14.Chengtie Wu*, Richard Miron, Anton Sculean, Stefan Kaskel, Thomas Doert, Renate Schulze, Yufeng Zhang*. Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds. Biomaterials 32(29):7068-78 (2011)  
　　15.Chengtie Wu, Yufeng Zhang, Yufang Zhu, Thor Friis, Yin Xiao*. Structure - property relationships of silk modified mesoporous bioglass scaffolds. Biomaterials 31(13): 3429-3438 (2010)
　　16.Yufeng Zhang, Chengtie Wu (Co-first author), Thor Friis, Yin Xiao*. The osteogenic properties of CaP/silk composite scaffolds. Biomaterials 31(10):2848-2856. (2010)
　　17.Chengtie Wu, Yogambaha Ramaswamy, Yufang Zhu, Rongkun Zheng, Richard Appleyard, Andrew Howard, Hala Zreiqat*. The effect of mesoporous bioglass on the physiochemical, biological and drug-release properties of poly (DL-lactide-co-glycolide) films. Biomaterials 30(12): 2199-2258 (2009)
　　18.Chengtie Wu, Yogambaha Ramaswamy, Danniel Kwik, Hala Zreiqat*. The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials 28:3171–81 (2007)
　　19.Chengtie Wu, Jiang Chang*, Junying Wang, Siyu Ni, Wanyin Zhai. Preparation and characteristics of a calcium magnesium silicate (Bredigite) bioactive ceramics. Biomaterials 26:2925–31 (2005)
　　20.Hongli Sun, Chengtie Wu, Kerong Dai*, Jiang Chang*, Tingting Tang. Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite-bioactive ceramics. Biomaterials 27:5651–57 (2006)
　　21.Yogambaha Ramaswamy, Chengtie Wu, Van Hummel A, Combes V, Grau G, Zreiqat H*. Responses of osteoblasts, osteoclasts & endothelial cells to zirconium modified calcium-silicate Based ceramic. Biomaterials 29(33):4392-4402 (2008)
　　22.Hala Zreiqat, Yogambha Ramaswamy, Chengtie Wu, Angelo Paschalidis, ZuFu Lu, Barbara James, Oliver Birke, Michelle McDonald, David Little, Colin Dunstan. The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials 31(12):3175-3184. (2010)
　　23.Xiaoguo Liu, Kaili Lin, Chengtie Wu, Yueyue Wang, Zaoyong Zou, Jiang Chang*. Multilevel hierarchically ordered artificial biomineral. Small 10(1):152-159. (2014)
　　24.Mengchi Xu, Dong Zhai, Lunguo Xia, Hong Li, Shiyi Chen, Bing Fang, Jiang Chang, Chengtie Wu*. Hierarchical bioceramic scaffolds with 3D-Plotted macropores and mussel-inspired surface nanolayers for stimulating osteogenesis. Nanoscale 8:13790-13803 (2016)
　　25.Yali Zhang, Lunguo Xia, Dong Zhai, Mengchao Shi, Yongxiang Luo, Chun Feng, Bing Fang, Jingbo Yin, Jiang Chang,* Chengtie Wu*. Mesoporous bioactive glass nanolayer-functionalized 3D-printed scaffolds for accelerating osteogenesis and angiogenesis. Nanoscale 7:19207-19221 (2015)
　　26.He Xu, Fang Lv, YaliZhang, ZhengfangYi,* Qinfei Ke,* ChengtieWu,* Mingyao Liu, Jiang Chang. Hierachically micro-patterned nanofibrious scaffolds with nanosized bio-glass surface for accelerating wound healing. Nanoscale 7(44):18446-52 (2015)
　　27.Chengtie Wu,* Lunguo Xia, Pingping Han, Lixia Mao, Jiacheng Wang, Dong Zhai, Bing Fang*, Jiang Chang*, Yin Xiao. Europium (Eu)-containing mesoporous bioactive glass scaffolds for stimulating in vitro and in vivo osteogenesis. ACS Appl Mater Interface 8:11342–11354 (2016)
　　28.Hong Li, Shiyi Chen,* Jiwu Chen, Jiang Chang, Mengchi Xu, Yaying Sun, Chengtie Wu*. Mussel-inspired artificial grafts for functional ligament reconstruction. ACS Applied Materials & Interfaces 7(27):14708-19. (2015).
　　29.Yongxiang Luo, Dong Zhai, Zhiguang Huan, Haibo Zhu, Luoguo Xia, Jiang Chang,* Chengtie Wu.* 3D printing of hollow struts-packed bioceramic scaffolds for bone regeneration. ACS Applied Materials & Interfaces 7(43):24377-83 (2015)
　　30.Chengtie Wu, Zetao Chen, Deliang Yi, Jiang Chang*, Yin Xiao*. Multidirectional effects of Sr, Mg and Si-containing bioceramic coatings with high bonding strength on inflammation, osteoclastogenesis and osteogenesis. ACS Applied Materials & Interfaces 6(6):4264-76 (2014).
　　31.Chengtie Wu*, Lunguo Xia, Pingping Han, Mengchi Xu, Bing Fang, Jiacheng Wang, Jiang Chang, Yin Xiao*. Graphene oxide modified beta-tricalcium phosphate bioceramics stimulate in vitro and in vivo osteogenesis. Carbon 93:116-129 (2015).
　　32.Jinyan Li, Dong Zhai, Fang Lv, Qingqing Yu, Hongshi Ma, Jingbo Yin, Zhengfang Yi,* Mingyao Liu, Jiang Chang, Chengtie Wu.* Preparation of copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing. Acta Biomaterialia 36;254-266 (2016)
　　33.Mengchao Shi, Zetao Chen, Saba Farnaghi, Thor Friis, Xueli Mao, Yin Xiao*, Chengtie Wu*. Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis. Acta Biomaterialia 30:334-344 (2016)
　　34.Mengchao Shi, Yinghong Zhou, Jin Shao, Zetao Chen, Botao Song, Jiang Chang*, Chengtie Wu*, Yin Xiao. Stimulation of osteogenesis and angiogenesis of hBMSCs by delivering Si ions and functional drug from mesoporous silica nanospheres. Acta Biomaterialia 21:178-189 (2015).
　　35.Chengtie Wu, Pingping Han, Xiaoguo Liu, Mengchi Xu, Tian Tian, Jiang Chang*, Yin Xiao*. Mussel-inspired β-tricalcium phosphate bioceramics with Ca-P/polydopamine hybrid nanolayer: preparation, formation mechanism and improved cellular bioactivity. Acta Biomaterialia 10(1):428-438 (2014).
　　36.Chengtie Wu*, Dong Zhai, Hongshi Ma, Xiaomin Li, Yali Zhang, Yinghong Zhou, Yongxiang Luo, Yueyue Wang, Yin Xiao, Jiang Chang*. Stimulation of osteogenic and angiogenic ability of cells on polymers by pulsed laser deposition of uniform akermanite-glass nanolayer. Acta Biomaterialia 10(7):3295-3306 (2014).
　　37.Mengchi Xu, Dong Zhai, Jiang Chang*, Chengtie Wu*. In vitro assessment of 3D-Plotted nagelschmidtite bioceramic scaffolds with varied macropore morphology. Acta Biomaterialia 10(1):463-476 (2014).
　　38.Chengtie Wu, Yinghong Zhou, Jiang Chang*, Yin Xiao*. Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells. Acta Biomaterialia 9(11):9159-9168 (2013)
　　39.Chengtie Wu, Yinghong Zhou, Chucheng Lin, Jiang Chang*, Yin Xiao*. Strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering. Acta Biomaterialia 8:3805-3815 (2012)
　　40.Yinghong Zhou, Chengtie Wu*, Yin Xiao*. The stimulation of proliferation and differentiation of periodontal ligament cells by the ionic products from Ca(7)Si(2)P(2)O(16) bioceramics. Acta Biomaterialia 8(6):2307-2316 (2012)
　　41.Chengtie Wu*, Wei Fan, Yufang Zhu, Michael Gelinsky, Jiang Chang, Giano Cuniberti, Victoria Albrecht, Thor Friis, Yin Xiao. Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure. Acta Biomaterialia 7(10):3563-3572 (2011)
　　42.Chengtie Wu*, Yongxiang Luo, Giano Cuniberti, Yin Xiao, Michael Gelinsky. 3D-Printing of hierarchical and tough mesoporous bioactive glass scaffolds with controllable pore architecture, excellent mechanical strength and mineralization ability. Acta Biomaterialia 7(6):2644-2650 (2011)
　　43.Chengtie Wu, Yufeng Zhang, Yinghong Zhou, Wei Fan, Yin Xiao. A comparative study of mesoporous-glass/silk and non-mesoporous-glass/silk scaffolds: physiochemistry and in vivo osteogenesis. Acta Biomaterialia 7(5):2229-2236 (2011)
　　44.Chengtie Wu*, Wei Fan, Michael Gelinsky, Yin Xiao, Paul Simon, Renate Schulze, Thomas Doert, Yongxiang Luo, Giano Cuniberti. Bioactive SrO-SiO2 glass with well-ordered mesopores: characterization, physiochemistry and biological properties. Acta Biomaterialia 7(4):1796-1806. (2011)  
　　45.Chengtie Wu, Yogambaha Ramaswamy, Hala Zreiqat*. Porous diopside (CaMgSi2O6) scaffold: a promising bioactive material for bone tissue engineering. Acta Biomaterialia 6(6):2237-2245 (2010)
　　46.Chengtie Wu, Hala Zreiqat*. Porous bioactive diopside (CaMgSi2O6) ceramic microspheres for drug delivery. Acta Biomaterialia 6(3):825-829. (2010)  
　　47.Chengtie Wu*, Wei Fan, Yinghong Zhou, Yongxiang Luo, Michael Gelinsky, Jiang Chang, Yin Xiao. 3D-Printing of highly uniform β-CaSiO3 ceramic scaffolds: preparation, characterization and in vivo osteogenesis. Journal of Materials Chemistry 22:12288-12295 (2012)  
　　48.Chengtie Wu, Jiang Chang*, Wei Fan*. Bioactive mesoporous calcium-silicate nanoparticles with excellent mineralization ability, osteostimulation, drug-delivery and antibacterial properties for filling apex root of tooth. Journal of Materials Chemistry 22:16801-16809 (2012)
　　49.Chengtie Wu*, Wei Fan, Jiang Chang, Yin Xiao. Mussel-inspired porous SiO2 scaffolds with improved mineralization and cytocompatibility for drug delivery and bone tissue engineering. Journal of Materials Chemistry 21 (45):18300-18307 (2011)  
联系方式：  
　　电话： 021-5241249
       E-mail： chengtiewu@mail.sic.ac.cn