中国科学院上海硅酸盐研究所李恺

nvshi

李恺，上海硅酸盐所副研究员。主要研究方向包括：1）病理状态下骨植入体表面生物涂层基础研究：基于骨微量营养元素和生物抗氧化剂在治疗骨质疏松、糖尿病和风湿性关节炎等方面的功能性，对涂层生物学性能进行改性研究。2）骨修复与替代材料产品研发：采用等离子喷涂技术和新型合金制备技术研发具有自主知识产权的，兼具优良生物学和力学性能的骨修复与替代材料产品（例如，人工关节、外固定螺钉和脊柱融合器等）。

姓 名:        李恺        性    别:        男
专家类别:        副研        学 历:        博士
电 话:        69163720        传 真:        无
电子邮件:        likai@mail.sic.ac.cn        个人主页:        无
邮政编码:        无        通讯地址:        无
         
简历：
教育经历：
2008/09 – 2013/07，上海硅酸盐研究所，材料学专业，博士学位
2004/09 – 2008/07，北京科技大学，无机非金属材料专业，学士学位
工作经历：
2017/12至今，上海硅酸盐研究所，特种无机涂层研究中心，硕士生导师
2016/07至今，上海硅酸盐研究所，特种无机涂层研究中心，副研究员
2013/07-2016/07，上海硅酸盐研究所，特种无机涂层研究中心，助理研究员

主持科研项目：                                      
1、国家自然科学基金青年项目（51502328），2016/1-2018/12，负责人，24万，在研。
2、上海市科技创新行动计划（17441904400），2017/7-2020/6，负责人，80万，在研。
3、GF科技创新特区，2018/10-2019/10，负责人，100万，在研。
4、上海硅酸盐所涂层重点实验室主任基金，2017/9-2019/9，负责人，20万，在研。
5、上海硅酸盐研究所科技创新项目，2018/10-2020/10，负责人，10万
6、GF科技创新特区，2017/8-2018/7，负责人，50万，已结题。
7、上海市骨科内植入物重点实验室开放基金（KFKT2016003），2016/1-2017/12，负责人，3万，已结题。
8、上海硅酸盐研究所科技创新项目，2014/1-2015/12，负责人，8万，已结题。

获得荣誉：
2018年 中国科学院第一届“率先杯”未来技术创新大赛全国60强，中科院上海分院国家级专业技术人员继续教育基地内部讲师，中科院上海硅酸盐研究所首届科普演讲比赛一等奖
2017年 中国科学院上海硅酸盐研究所“优秀青年”、年度“优秀个人”

发表SCI论文
2018年
1. Kai Li, Dandan Hu, Youtao Xie, Liping Huang and Xuebin Zheng*. Sr-doped nanowires modification of Ca-Si based coatings for improved osteogenic activities and reduced inflammatory reactions. Nanotechnology. 2018, 29: 084001.
2. Kai Li, Qingyi Shen, Youtao Xie, Mingyu You, Liping Huang and Xuebin Zheng*. Incorporation of Cerium Oxide into Hydroxyapatite Coating Protects Bone Marrow Stromal Cells Against H2O2-Induced Inhibition of Osteogenic Differentiation. Biological Trace Element Research. 2018, 182: 91-104.
3. Lin Lv, Youtao Xie, Kai Li*, Tao Hu, Xiang Lu, Yunzhen Cao,* and Xuebin Zheng*. Unveiling the Mechanism of Surface Hydrophilicity-Modulated Macrophage Polarization. Advanced Healthcare Materials. 2018, 7(19): e1800675. (IF: 5.6) （通讯作者）
4. Xiang Lu, Kai Li*,Youtao Xie, Shengcai Qi, Qingyi Shen, Jiangming Yu, Liping Huang, Xuebin Zheng*. Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects. Journal of Biomedical Materials Research: Part A. 2018. doi: 10.1002/jbm.a.36456.
5. Jiangming Yu, Kai Li*, et al. Adhesion behavior of Escherichia coli on plasma-sprayed Zn and Ag co-incorporated calcium silicate coatings with varying surface roughness. Journal of Thermal Spray Technology. 2018. doi.org/10.1007/s11666-018-0800-5. （通讯作者）
6. Ding Ding, Youtao Xie, Kai Li, Liping Huang, Xuebin Zheng. Black plasma-sprayed Ta2O5 coatings with photothermal effect for bone tumor therapy. Ceramics International. 2018, 44(11): 12002-12006.
7. Ding Ding, Youtao Xie, Kai Li, Liping Huang, Xuebin Zheng. Micro/nano structural tantalum coating for enhanced osteogenic differentiation of human bone marrow stem cells. Materials. 2018, 11(4): 546.
8. Ding D, Xie Y, Li K, Zheng X. A Comparative Study of Vacuum and Atmospheric
Plasma  Sprayed  Tantalum  Coating  for  Modification  of  Titanium Implants.  Surface Review and Letters. 2018. doi.org/10.1142/S0218625X19500495

2017年
1. Kai Li, Qingyi Shen, Youtao Xie, Mingyu You, Liping Huang and Xuebin Zheng*. Incorporation of cerium oxide into hydroxyapatite coating regulates osteogenic activity of mesenchymal stem cell and macrophage polarization. Journal of biomaterials applications. 2017, 31(7): 1062-1076.
2. Kai Li, Jiangming Yu, Youtao Xie, Mingyu You, Liping Huang and Xuebin Zheng*. The effects of cerium oxide incorporation in calcium silicate coating on bone mesenchymal stem cell and macrophage response. Biological Trace Element Research. 2017, 177: 148-158.
3. Mingyu You, Kai Li*, Youtao Xie, Liping Huang and Xuebin Zheng*. The effects of cerium valence states at cerium oxide coatings on the responses of bone mesenchymal stem cells and macrophages. Biological Trace Element Research. 2017, 179: 259-270.  （通讯作者）
4.  Dandan Hu, Kai Li*, Youtao Xie, Houhua Pan, Jun Zhao, Liping Huang and Xuebin Zheng*. The combined effects of nano-topography and Sr ion for enhanced osteogenic activity of bone marrow mesenchymal stem cells (BMSCs). Journal of Biomaterials Applications. 2017, 31(8): 1135-1147. （通讯作者）
5. Jiangming Yu, Lizhang Xu, Kai Li, Ning Xie, Yanhai Xi, Yang Wang, Xuebin Zheng, Xiongsheng Chen, Meiyan Wang, Xiaojian Ye*. Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits. Scientific reports. 2017, 7: 3440. （共同第一作者）
6.  Lin Lv, Kai Li, Youtao Xie, Yunzhen Cao*, Xuebin Zheng*. Enhanced osteogenic activity of anatase TiO2 film: surface hydroxyl groups induce conformational changes in fibronectin. Materials Science and Engineering C, 2017, 78: 96-104. (IF: 5.0)
7.  Houhua Pan, Youtao Xie, Zequan Zhang, Kai Li, Dandan Hu, Jun Zhao, Xuebin Zheng*, Tingting Tang*. Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway. RSC Advances. 2017, 7, 8521.
8.  Houhua Pan, Youtao Xie, Zequan Zhang, Kai Li, Dandan Hu, Jun Zhao, Xuebin Zheng*, Tingting Tang*. Immunomodulation effect of a hierarchical macropore/nanosurface on osteogenesis and angiogenesis. Biomedical Materials. 2017, 12, 045006.
9. Houhua Pan, Youtao Xie, Zequan Zhang, Kai Li, Dandan Hu, Xuebin Zheng*, Qiming Fan*, Tingting Tang*. YAP-mediated mechanotransduction regulates osteogenic andadipogenic differentiation of BMSCs on hierarchical structure. Colloids and Surfaces B: Biointerfaces. 2017, 152: 344–353.
10. Jiangming Yu, Lizhang Xu, Kai Li, Ning Xie, Yanhai Xi, Yang Wang, Xuebin Zheng, Xiongsheng Chen, Meiyan Wang, Xiaojian Ye*. Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits. Scientific Reports. 2017, 7: 3440. （共同第一作者）
11.  Ding, D., Xie, Y., Li, K., Huang, L., Zheng, X. Improved Mechanical Compatibility and Cytocompatibility of Ta/Ti Double-Layered Composite Coating. Journal of Thermal Spray Technology. 2017, 26(6): 1292-1300.
12.  Jiangming Yu, Lizhang Xu, Ning Xie, Kai Li, Yanhai Xi, Xiling Liu, Xuebin Zheng, Xiongsheng Chen, Xiaojian Ye, and Daixu Wei. Optimal Zn-Modified Ca–Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering. Journal of Nanomaterials. 2017. doi.org/10.1155/2017/7374510

2016年
1. Kai Li, Youtao Xie, Mingyu You, Liping Huang and Xuebin Zheng*. Plasma sprayed cerium oxide coating inhibits H2O2-induced oxidative stress and supports cell viability. Journal of Materials Science: Materials in Medicine, 2016, 27, 100.
2. Kai Li, Youtao Xie, Mingyu You, Liping Huang and Xuebin Zheng*. Cerium oxide-incorporated calcium silicate coating protects MC3T3-E1 cells from H2O2-induced oxidative stress. Biological Trace Element Research, 2016, 174: 198-207.
3. Xiang Lu, Kai Li*, Youtao Xie, Liping Huang and Xuebin Zheng*. Chemical stability and osteogenic activity of plasma-sprayed boron-modified calcium silicate-based coatings. Journal of Materials Science: Materials in Medicine, 2016, 27, 166. （通讯作者）
4. Dandan Hu, Kai Li*, Youtao Xie, Houhua Pan, Jun Zhao, Liping Huang and Xuebin Zheng*. Different response of osteoblastic cells to Mg2+, Zn2+ and Sr2+ doped calcium silicate coatings. Journal of Materials Science: Materials in Medicine, 2016, 27, 56. （通讯作者）
5. Haiyong Ao, Youtao Xie, Shengbing Yang, Xiaodong Wu, Kai Li, Xuebin Zheng and Tingting Tang. Covalently immobilised type I collagen facilitates osteoconduction and osseointegration of titanium coated implants. Journal of Orthopaedic Translation. 2016, 5: 16-25. （2017年JOT高引用文章）
6. Yunqi Shi, Youtao Xie*, Houhua Pan, Xuebin Zheng*, Liping Huang, Fang Ji and Kai Li. Plasma-sprayed titanium patterns for enhancing early cell responses. Journal of Thermal Spray Technology, 2016, 25, 5: 946-958.

2011-2015年
1. Kai Li, Youtao Xie, Liping Huang, Heng Ji, Xuebin Zheng*. Antibacterial mechanism of plasma sprayed Ca2ZnSi2O7 coating against Escherichia coli. Journal of Materials Science: Materials in Medicine, 2013, 24, 171-178.
2. Kai Li, Jiangming Yu, Youtao Xie, Liping Huang, Xiaojian Ye, Xuebin Zheng*. Effects of Zn content on crystal structure, cytocompatibility, antibacterial activity and chemical stability in Zn-modified calcium silicate coatings. Journal of Thermal Spray Technology, 2013, 22, 965-973.
3. Kai Li, Youtao Xie, Haiyong Ao, Liping Huang, Heng Ji, Xuebin Zheng*. The enhanced bactericidal effect of the zinc-modified calcium silicate coating by the addition of silver. Ceramics International, 2013, 39, 7895-7902.
4. Jiangming Yu, Kai Li, Xuebin Zheng, Dannong He, Xiaojian Ye*, Meiyan Wang. In vitro and in vivo evaluation of zinc-modified Ca–Si-based ceramic coating for bone implants. Plos One, 2013, 8, e57564. （共同第一作者）
5. Kai Li, Jiangming Yu, Youtao Xie, Liping Huang, Xiaojian Ye, Xuebin Zheng*. Chemical stability and antimicrobial activity of plasma sprayed bioactive Ca2ZnSi2O7 coating. Journal of Materials Science: Materials in Medicine, 2011, 22, 2781-2789.
6. Houhua Pan, Youtao Xie, Kai Li, Dandan Hu, Jun Zhao, Xuebin Zheng*. ROCK-regulated synergistic effect of macrophage/nanowire topography on cytoskeletal distribution and cell differentiation. RSC Advances, 2015, 5, 101834.
7. Youtao Xie*, Hongqin Li, Chuanxian Ding, Xuebin Zheng* and Kai Li. Effects of graphene plates’ adoption on the microstructure, mechanical properties, and in vivo biocompatibility of calcium silicate coating. International Journal of Nanomedicine, 2015, 10: 3855-3863.
8. Hongqing Li, Youtao Xie, Kai Li, Liping Huang, Shansong Huang, Bizeng Zhao, Xuebin Zheng*. Microstructure and wear behavior of graphene nanosheets-reinforced zirconia coating. Ceramics International, 2014, 40(8): 12821-29.
9. Haiyong Ao, Youtao Xie, Honglue Tan, Shengbing Yang, Kai Li, Xiaodong Wu, Xuebin Zheng* and Tinging Tang. Fabrication and in vitro evaluation of stable collagen/hyaluronic acid biomimetic multilayer on titanium coatings. Journal of the Royal Society Interface. 2013, 10: 20130070.

发明专利：
1. 李恺，谢有桃，黄利平，季珩，郑学斌。“一种抗降解和抗菌性能良好的生物涂层及其制备方法”，授权专利号：ZL201210051733.9
2. 李恺，谢有桃，黄利平，郑学斌。“一种抗氧化生物涂层及其制备方法”，公开号：CN106913906A
3. 李恺，谢有桃，黄利平，郑学斌。“一种抗降解和抗菌性能良好的二氧化铈掺杂硅酸钙涂层及其制备方法和应用”，公开号：CN106913905A
4. 李恺，谢有桃，黄利平，郑学斌。“一种生物抗氧化性能良好的二氧化铈掺杂羟基磷灰石涂层及其应用”，公开号：CN107638591A
5. 陆翔，李恺，黄利平，谢有桃，郑学斌。“一种掺硼硅酸钙生物活性涂层的制备方法”，公开号：CN106668942A
6. 吕林，谢有桃，李恺，曹韫真，郑学斌。“一种二氧化钛薄膜及其制备方法和应用”，公开号：CN107815665A。
7. 顾静萍，谢有桃，李恺，黄利平，赵君，贺延昌，郑学斌。“一种具有优良生物相容性的微米/纳米多级结构二氧化钛涂层及其制备方法”，公开号：CN108588626A。