华东理工大学化学与分子工程学院朱为宏

sujue · 发表于 2018-3-25 17:00:13

朱为宏,华东理工大学教授，教育部长江学者特聘教授，国家杰出青年基金获得者，主要研究领域为精细化工（染料），围绕有机功能染料稳定性强化机制展开工作。至今已在Angew. Chem. Int. Ed., J. Am. Chem. Soc., Energy Environ. Sci., Adv. Mater., Adv. Energy Mater., Adv. Funct. Mater., Chem. Sci., Chem. Mater., Biomaterials, Sci. Rep., Chem. Commun., AIChE J等发表 SCI收录论文近230篇，共被SCI他引万余次， H指数为58。

个人简历
1988.09-1992.07       南京师范大学化学系，学士
1992.09-1995.07       天津南开大学化学系，硕士（有机合成专业），导师：汪小兰教授
1996.09-1999.07       华东理工大学精细化工研究所，博士（应用化学），导师：田禾院士
2001.10-2003.09       日本筑波国立产业技术综合研究院（AIST），博士后，导师：Minami博士
2004.07-2005.03       日本筑波大学先进学际研究中心（TARA Center），访问教授，合作导师：Akasaka教授
2014.06       美国华盛顿州立大学（WSU）高级访问学者
1995.09-2004.08       华东理工大学精细化工研究所，助教、讲师、副教授
2004.09-       华东理工大学精细化工研究所，教授
2005.06-2016.02       华东理工大学精细化工研究所，博士生导师，常务副所长
2016.03-2017.04       华东理工大学精细化工研究所，博士生导师，化学与分子工程学院院长
2017.03-至今       华东理工大学科学技术发展研究院常务副院长

获奖及荣誉称号
2016       上海市化学协会理事
2016       入选第二批国家“万人计划”科技创新领军人才
2016       上海市自然科学牡丹奖
2015       教育部长江学者特聘教授
2015       上海市学术带头人
2014       科技部创新人才推进计划
2013       国家杰出青年基金
2013       国际期刊“Dyes and Pigments” （IF=4.0）编委
2011       《影像科学与光化学》学报第七届编委，第八届常务副主编
2011       上海高校特聘教授（东方学者）跟踪支持，上海市教育委员会
2010       中国感光学会第八届、第九届理事会常务理事
2009       上海高校特聘教授（东方学者），上海市教育委员会
2007       “曙光学者”，上海市教育委员会
2007       “有机荧光功能材料”获国家自然科学奖二等奖（排序第三）
2006       “有机光电功能材料与分子机器”荣获上海市自然科学一等奖（排序第三）
2006       “新世纪优秀人才”，教育部
2006       《感光科学与光化学》学报第六届编委
2004       “霍英东青年教师奖” 二等，霍英东教育基金会
2001       “上海市科技启明星”，上海市科委
2001       全国优秀博士论文，教育部

授课名称       授课对象
1       荧光（探针）染料                《科技英语》       本科生
2       光致变色染料                《染料化学》       硕士生
3       有机太阳能电池敏化染料                《工业化学与工艺》       硕士生
                        《有机合成原理（含高等有机化学）》       硕士生
                        《有机光电功能材料讲座》       博士生
                        《Functional Materials （英文授课）》       博士生

围绕有机功能染料稳定性强化机制展开工作：
1       成功发展高稳定性敏化染料，系统引入额外的强吸电子基团作为电荷分离“阱”受体，提出D-A-π-A型概念，显著提升敏化染料稳定性及光电转换效率；
2       创新构建高双稳态光致变色染料，系统研究烯桥芳香度与光致变色双稳态关系，创新地通过引入新型烯桥体系和环化法提高闭环体的稳定性，突破传统六元环烯桥闭环体不稳定观念，发展了新型自组装、荧光可控、光响应的光致变色材料；
3       推广高稳定性荧光染料制备方法，系统优化嵌段聚合物、硅基包裹制备条件，具有普适性；揭示了新型红光的喹啉腈类聚集诱导荧光增强现象；
4       注重产业化应用，发展高稳定性pH、溶解氧传感膜，成功应用于微型发酵罐在线检测，实现高稳定性光致变色镜片产业化，稳占国内市场。

近几年发表论文：
  2012年
  1. Weihong Zhu,* Liwen Song, Yuheng Yang, and He Tian, Novel Bisthienylethene Containing Ferrocenyl Substituted Naphthalimide: Photo- and Redox Multi-addressable Molecular Switch, Chem. Eur. J., 2012, DOI: 10.1002/chem.201202189. (IF 5.925)
  2. Xinyu Lu, Zhiqian Guo, Mingxiang Feng, Weihong Zhu*, Sensing performance enhancement via acetate-mediated N-acylation of thiourea derivatives: A novel fluorescent turn-on Hg2+ chemodosimeter, ACS Applied Materials & Interfaces, 2012, dx.doi.org/10.1021/am300751p (IF 4.525)
  3. Shu Chang, Xumeng Wu, Yongsheng Li,* Dechao Niu, Zhi Ma, Wenru Zhao, Jinlou Gu, Wenjie Dong, Feng Ding, Weihong Zhu,* and Jianlin Shi*, A Hydrophobic Dye-Encapsulated Nano-Hybrid as an Efficient Fluorescent Probe for Living Cell Imaging, Adv. Healthcare Mater., 2012, DOI: 10.1002/adhm.201200144.
  4. Yongzhen Wu, Magdalena Marszalek, Shaik M. Zakeeruddin*, Qiong Zhang, He Tian, Michael Grätzel*, and Weihong Zhu*, High-Conversion-Efficiency Organic Dye-Sensitized Solar Cells: Molecular Engineering on D-A-π-A Featured Organic Indoline Dyes, Energy & Environmental Science, 2012, DOI: 10.1039/C2EE22108J. (IF 9.61; Solar cell sensitizers: Efficiency > 9%).
  5. Sanyin Qu, Chuanjiang Qin, Ashraful Islam, Yongzhen Wu, Weihong Zhu, Jianli Hua, He Tian* and Liyuan Han*. A novel D-A-π-A organic sensitizer containing diketopyrrolopyrrole unit with branched alkyl chain for highly efficient and stable dye-sensitized solar cells. Chem. Common. 2012, 48, 6972–6974. (IF 6.169)
  6. Yuheng Yang, Yongshu Xie, Qiong Zhang, Keitaro Nakatani, He Tian, and Weihong Zhu*,  Aromaticity-Controlled Thermal Stability of Photochromic Systems Based on Six-Membered Ring as Ethene Bridges: Photochemical and Kinetic Studies", Chem. Eur. J., 2012, DOI: 10.1002/chem.201200354. (IF 5.925; VIP paper: systematic study on the aromaticity-controlled thermal stability of photochromic systems)
  7. Kai Pei, Yongzhen Wu, Wenjun Wu, Qiong Zhang, Baoqin Chen, He Tian and Weihong Zhu*, Constructing organic D-A-π-A featured sensitizers with quinoxaline unit for high efficient solar cells: effect of auxiliary acceptor on absorption and electron transition, Chem. Eur. J., 2012, 18, 8190–8200. (IF 5.925, Solar cell sensitizers with quinoxaline unit as new additional acceptor)
  8. Bo Liu*, Qingbin Liu, Xiaoyan Li, Dan You, Yoshinori Naruta, and Weihong Zhu*, Molecular engineering of indoline based organic sensitizers for highly efficient dye-sensitized solar cells, J. Mater. Chem., 2012, 22, 13348–13356. (5.968)
  9. Zhiqian Guo, Weihong Zhu* and He Tian, Dicyanomethylene-4H-pyran chromophores for OLED emitters, logic gates and optical chemosensors, Chem. Commun., 2012, 48, 6073–6084. (Feature Article: chemosensors, IF 6.169).
  10. Yubin Ding, Tong Li, Weihong Zhu*, and Yongshu Xie*, Highly selective colorimetric sensing of cyanide based on formation of dipyrrin adducts, Organic & Biomolecular Chemistry, 2012, 10, 4201–4207. (IF 3.696)
  11. Wenqin Li, Yongzhen Wu, Qiong Zhang, He Tian, and Weihong Zhu*, D-A-π-A Featured Sensitizers Bearing Phthalimide and Ben-zotriazole as Auxiliary Acceptor: Effect on Absorption and Charge Recombination Dynamics in Dye-Sensitized Solar Cells, ACS Appl. Mater. Interfaces, 2012, 4, 1822−1830. (IF 4.525)
  12. Bo Liu, Weihong Zhu*, Wenjun Wu, Xin Li, Baoqin Chen, Yi-Tao Long, Yueqiang Wang and Yongshu Xie*, Modulation of energy levels by donors groups: an effective approach for optimizing the efficiency of Zinc-porphyrin based solar cells, J. Mater. Chem., 2012, 22, 7434–7444. (5.968)
  13. Jian Cao, Chunchang Zhao*, Weihong Zhu*, A near-infrared fluorescence chemodosimeter for fluoride via specific Si-O cleavage, Tetrahedron Lett., 2012, 53, 2107–2110. (IF 2.683)
  14. Shangjun Chen, Yuheng Yang, Yue Wu, He Tian and Weihong Zhu*, Multi-Addressable Photochromic Terarylene Containing Benzothiophene-1,1-dioxide Unit as Ethene Bridge: Multifunctional Molecular Logic Gates on Unimolecular Platform, J. Mater. Chem., 2012, 22, 5486–5494. (5.968)
  15. Yongzhen Wu, Xi Zhang, Wenqin Li, Zhong-Sheng Wang*, He Tian and Weihong Zhu*, Hexylthiophene Featured D-A-π-A Structural Indoline Chromophores for Coadsorbent-Free and Panchromatic Dye-Sensitized Solar Cells, Advanced Energy Materials, 2012, 2, 149–156.
  16. Weihong Zhu,* Xiaomei Huang, Zhiqian Guo, Xumeng Wu, Huihui Yu and He Tian, A novel NIR fluorescent turn-on sensor for the detection of pyrophosphate anion in complete water system, Chem. Commun., 2012, 48, 1784–1786. (IF 6.169)
  17. Bo Liu, Xiaoyan Li, Miaoyin Liu, Zhijun Ning, Qiong Zhang, Chen Li, Klaus Müllen, and Weihong Zhu*, Photovoltaic Performance of Solid-State DSSCs Sensitized with Organic Isophorone Dyes: Effect of Dye-loaded Amount and Dipole Moment, Dyes and Pigments, 2012, 94, 23–27. (3.126)
  18. Jian Cao, Chunchang Zhao*, Peng Feng, Yulin Zhang, Weihong Zhu*, A colorimetric and ratiometric NIR fluorescent turn-on fluoride chemodosimeter based on BODIPY derivatives: high selectivity via specific Si-O cleavage, RSC Advances, 2012, 2, 418–420.
  19. Yue Wu, Shangjun Chen, Yuheng Yang, Qiong Zhang, Yongshu Xie, He Tian, Weihong Zhu*, A novel gated photochromic reactivity controlled by complexation/dissociation with BF3, Chem. Commun., 2012, 48, 528–530. (IF 6.169)

2011年
  20. Liwen Song, Yuheng Yang, Qiong Zhang, He Tian, Weihong Zhu*, Synthesis and Photochromism of Naphthopyrans Bearing Naphthalimide Chromophore: Predominant Thermal Reversibility in Color-fading and Fluorescence Switch, J. Phys. Chem. B, 2011, 115, 14648–14658. (IF 3.696)
  21. Weihong Zhu*, Yuheng Yang, Rémi Métivier, Qiong Zhang, Régis Guillot, Yongshu Xie, He Tian, and Keitaro Nakatani*, Unprecedented Stability of a Photochromic Bisthienylethene Based on Benzobisthiadiazole as an Ethene Bridge, Angew. Chem. Int. Ed., 2011, 50, 10986–10990. (IF 13.455; Photochromic system with a new ethene bridge: which can be comparable to the Irie’s perfureocyclopentene system)
  22. Yan Cui, Yongzhen Wu, Xuefeng Lu, Xi Zhang, Gang Zhou*, Fohn B. Miapeh, Weihong Zhu*, and Zhong-Sheng Wang*, Incorporating Benzotriazole Moiety to Construct D-A-π-A Organic Sensitizers for Solar Cells: Significant Enhancement of Open-Circuit Photovoltage with Long Alkyl Group, Chem. Mater., 2011, 23, 4394–4401. (IF 7.286)
  23. Xinyu Lu, Zhiqian Guo, Chunyu Sun, He Tian and Weihong Zhu*, Helical Assembly Induced by Hydrogen-Bonding from Chiral Carboxylic Acid Based on Perylene Bisimides, J. Phys. Chem. B, 2011, 115, 10871–10876. (IF 3.696)
  24. Liangjun Shen, Xinyu Lu, He Tian, Weihong Zhu*, A Long Wavelength Fluorescent Hydrophilic Copolymer Based on Naphthalenediimide as pH Sensor with Broad Linear Response Range, Macromolecules, 2011, 44, 5612–5618. (IF 5.167)
  25. Wenqin Li, Yongzhen Wu, Xin Li, Yongshu Xie, Weihong Zhu*, Absorption and photovoltaic properties of organic solar cell sensitizers containing fluorene unit as conjunction bridge, Energy & Environmental Science, 2011, 4, 1830–1837 (IF 9.61).
  26. Yubin Ding, Yongshu Xie,* Xin Li, Jonathan P. Hill,* Weibing Zhang and Weihong Zhu, Selective and sensitive “turn-on” fluorescent Zn2+ sensors based on di- and tripyrrins with readily modulated emission wavelengths, Chem. Commun., 2011, 47, 5431–5433. (IF 6.619)
  27. Cai-Xia Ding, Jia Ni, Chang-Hua He, Fan-Hua Zeng, Wei-Hong Zhu, Yong-Shu Xie*, A zipper-like double chain coordination polymer constructed from a novel pseudo-macrocyclic binuclear Cu(II) complex, Inorg. Chem. Commun., 2011, 14, 370–373 (IF 1.972)
  28. Bo Liu,* Wenjun Wu, Xiaoyan Li, Lei Li, Shaofu Guo, Xiaoru Wei, Weihong Zhu and Qingbin Liu*,  Molecular engineering and theoretical investigation of organic sensitizers based on indoline dyes for quasi-solid state dye-sensitized solar cells, Phys. Chem. Chem. Phys., 2011, 13, 8985–8992. (IF 3.573)
  29. Weihong Zhu, Yongzhen Wu, Shutao Wang, Wenqin Li, Xin Li, Jian Chen, Zhongsheng Wang,* and He Tian,*Organic D-A-π-A solar cell sensitizers with improving stability and spectral response, Adv. Funct. Mater., 2011, 21, 756–763. (IF 10.179; Solar cell sensitizers with benzothiadiazole unit as new additional acceptor: highlighted by Materials view China; selected as highly cited paper and hot paper by Essential Science Indicator)
  30. Xiaomei Huang, Yi Fang*, Xin Li, Yongshu Xie, Weihong Zhu*, Novel dyes based on naphthalimide moiety as electron acceptor for efficient dye-sensitized solar cells, Dyes & Pigments, 2011, 90, 297–303. (IF 3.126)
  31. Liangjun Shen, Ping Zhao, Weihong Zhu*, A ratiometric hydrophilic fluorescent copolymer sensor based on benzimidazole chromophore for microbioreactors, Dyes & Pigments, 2011, 89, 236–240. (IF 3.126)
  32. Ha Na Kim, Zhiqian Guo, Weihong Zhu, Juyoung Yoon*, and He Tian*, Recent progress on polymer-based fluorescent and colorimetric chemosensors, Chem. Soc. Rev., 2011, 40, 79–93. (IF 28.76)

2010年
  33. Zhiqian Guo, Weihong Zhu*, Mingming Zhu, Xumeng Wu and He Tian*, NIR cell-permeable Hg2+-selective ratiometric fluorescent chemodosimeters and fast indicator paper for MeHg+ based on tricarbocyanines, Chem. Eur. J., 2010, 16, 14424–14432. (IF 5.925).
  34. Hu Xu, Xiaomei Huang, Wenjin Zhang, Guanjiao Chen, Weihong Zhu, Xinhua Zhong*, Quantum Dots Acting as Energy Acceptors with Organic Dyes as Donors in Solution, ChemPhysChem, 2010, 11(14), 3167–3171. (IF 3.412)
  35. Quanguo Wang, Seik-Weng Ng, Yongshu Xie*, Weihong Zhu. Hydrothermal Synthesis and Crystal Structure of ZnTPP Axially Coordinated with a Novel Dipyridylamine Ligand, Chinese J. Struct. Chem., 2010, 29, 1197–1200. (IF 0.44)
  36. Xinyu Lu, Weihong Zhu*, Yongshu Xie, Xin Li, Yuan Gao, Fuyou Li, He Tian*, Near-infrared core-substituted naphthalenediimide fluorescent chemosensors for zinc ions: ligand effect on PET and ICT channels, Chem. Eur. J., 2010, 16, 8355–8364. (IF 5.925)
  37. Quanguo Wang, Yongshu Xie*, Fanhua Zeng, Seik-Weng Ng, Weihong Zhu. A triple chain coordination polymer constructed from ZnTPP and a bis(4,4-dipyridylamine) ligand. Inorg. Chem. Commun., 2010, 13, 929–931. (IF 1.974)
  38. Quanguo Wang, Yongshu Xie*, Yubin Ding, Xin Li, Weihong Zhu*. Colorimetric fluoride sensors based on deprotonation of pyrrole-hemiquinone compounds, Chem. Commun., 2010, 46, 3669–3671 (IF 6.619)
  39. Fanhua Zeng, Jia Ni, Quanguo Wang, Yubin Ding, Seik Weng Ng, Weihong Zhu and Yongshu Xie*,  Synthesis, structures, and photoluminescence of Zinc(II), Cadmium(II), and Mercury(II) coordination polymers constructed from two novel tetrapyridyl ligands, Crystal Growth Design, 2010, 10, 1611–1622. (IF 4.72)
  40. Weihong Zhu*, Xianle Meng, Yuheng Yang, Qiong Zhang, Yongshu Xie, and He Tian*, Bisthienylethenes containing benzothiadiazole unit as bridge: photochromic performance dependent upon substitution position, Chem. Eur. J., 2010, 16, 899–906. (IF 5.925)
  41. Zhiqian Guo, Weihong Zhu*, He Tian*, Hydrophilic Copolymer Bearing Dicyanomethylene-4H-pyran moiety as fluorescent film sensor for Cu2+ and pyrophosphate anion, Macromolecules, 2010, 43, 739–744. (IF 5.167)

2009年
  42. Z. Fang, Z. Y. Gu, Weihong Zhu, Xinhua Zhong*, Design and synthesis of high-quality CdS/ZnSe Type-II core/shell nanocrystals, J. Nanosci. & Nanotech., 2009, 9, 5880–5886. (IF 1.563)
  43. Ping Zhao, Hao Tang, Qiong Zhang, Yajuan Pi, Min Xu, Runguang Sun, Weihong Zhu*, Facile synthesis and high efficiency of red electroluminescent dopant DCINB: a promising alternative to DCJTB, Dyes & Pigments, 2009, 82, 316–321. (IF 3.126)
  44. Liangjun Shen, Weihong Zhu*, Xianle Meng, Zhiqian Guo and He Tian, A hydrophilic fluorescent polymer containing naphthalimide moiety as chemosensor for microbioreactor, Science in China Series B: Chem., 2009, 52, 821–826. (IF 1.199)
  45. Zhiqian Guo, Weihong Zhu*, Yuyan Xiong and He Tian*, Multiple logic fluorescent thermometer system based on N-isopropyl methacrylamide copolymer bearing dicyanomethylene-4H-pyran moiety, Macromolecules, 2009, 42, 1448–1453. (IF 5.167)
  46. Bo Liu, Weihong Zhu*, Qiong Zhang, Wenjun Wu, Min Xu, Zhijun Ning, Yongshu Xie and He Tian* , Conveniently synthesized isophorone dyes for high efficiency dye-sensitized solar cells: tuning photovoltaic performance by structural modification of donor group in donor-π-Acceptor system, Chem. Comm., 2009, 46, 1766–1768. (IF 6.619)
  47. Yongshu Xie*, Jia Ni, Fakun Zheng, Yong Cui, Quanguo Wang, Seik Weng Ng, and Weihong Zhu,
  Tetra- and binuclear complexes of hydroxy-rich ligands: supramolecular structures, stabilization of unusual water clusters, and magnetic properties, Cryst. Growth Design, 2009, 9, 118–126. (IF 4.72)

2008年
  48. Xianle Meng, Weihong Zhu*, Qiong Zhang, Yanli Feng, Wenjuan Tan, and He Tian*, Novel bisthienylethenes containing naphthalimide as center ethene bridge: photochromism and solvatochromism for combined NOR and INHIBIT logic gates, J. Phys. Chem. B, 2008, 112, 15636–15645. (IF 3.696)
  49. Xiaomei Huang, Zhiqian Guo, Weihong Zhu*, Yongshu Xie and He Tian*, A colorimetric and fluorescent turn-on sensor for pyrophosphate ions based on dicyanomethylene-4H-chromene framework, Chem. Comm., 2008, (41), 5143–5145. (IF 6.619)
  50. Yajuan Pi, Hao Tang, Guosheng Zhao, Runguang Sun, Weihong Zhu*, Synthesis and electroluminescent properties of red dopant with high color purity, Acta Chimica Sinica, 2008, 66, 1460–1464  (IF 0.533)
  51. Lei Zou, Zhenyu Gu, Nan Zhang, Yuliang Zhang, Zheng Fang, Weihong Zhu, Xinhua Zhong*, Ultrafast synthesis of highly luminescent green-to near infrared-emitting CdTe nanocrystals in aqueous phase, J. Mater. Chem., 2008, 18, 2807–2815. (IF 5.968)
  52. Zhenyu Gu, Weihong Zhu, Xinhua Zhong*, New methods for tuning band gap of colloidal semiconductor nanocrystals, Progress in Chemistry, 2008, 20, 629–636.
  53. Jiaqiang Ren, Weihong Zhu, He Tian*, A Highly Sensitive and Selective Chemosensor Cyanide, Talanta, 2008, 75, 760-764. (IF 3.794)
  54. Zhiqian Guo, Ping Zhao, Weihong Zhu*, Xiaomei Huang, Yongshu Xie and He Tian*, Intramolecular charge-transfer process based on dicyanomethylene-4H-pyran derivative: an integrated operation of half-subtractor and comparator, J. Phys. Chem. C, 2008, 112, 7047–7053. (IF 4.805)
  55. Guohua Ding, Zhaowu Xu, Gaoyu Zhong, Shuping Jing, Fuyou Li, Weihong Zhu*, Synthesis, photophysical and electroluminescent properties of novel naphthalimide derivatives containing an electron-transporting unit, Res. Chem. Intermed., 2008, 34, 299–308. (IF 0.697).
  56. Z. Y. Gu, L. Zou, Z. Fang, Weihong Zhu, Xinhua Zhong*, One-pot synthesis of highly luminescent CdTe/CdS core/shell nanocrystals in aqueous phase, Nanotechnology, 2008, 19, 135604. (IF 3.979)
  57. Bo Liu, Weihong Zhu*, Wenjun Wu, Kwang Mu Ri, and He Tian*, Hybridized ruthenium(II) complexes with high molar extinction coefficient unit: effect of energy band and adsorption on photovoltatic performances, J. Photochem. Photobiol. A: Chem., 2008, 194, 268–274. (IF 2.413).
  58. Weihong Zhu*, Liqiang Fan, Room temperature phosphorescence of palladium (II) complex sensitized by unsymmetric perylene bisimide, Dyes & Pigments, 2008, 76, 663–668. (IF 3.126).

2007年
  59. Xianle Meng, Weihong Zhu*, He Tian*, Dendrimeric electroluminescent materials, Progress in Chemistry, 2007, 19, 1671–1680. (IF 0.556)
  60. Xinyu Lu, Weihong Zhu*, Chinese Journal of Organic Chemistry, 2007, 27(11), 1352–1357. (IF 0.608)
  61. Zhiqian Guo, Weihong Zhu*, Liangjun Shen, He Tian*, A fluorophore capable of crossword puzzles and logic memory, Angew. Chem. Int. Ed., 2007, 46, 5549–5553. (IF 13.455)
  62. Weihong Zhu*, Xiaofang Bi, Bo Liu, Synthesis and luminescence-tuning of naphthalimide-triphenylamine dyad, Acta Chimica Sinica, 2007, 65, 1207–1211 (IF 0.533)
  63. Danli Zeng, Junwu Chen, Zhao Chen, Weihong Zhu, Jun He, Feng Yu, Hao Huang, Huanrong Wu, Chang Liu, Shijie Ren, Junping Du, Jing Sun, Erjian Xu, Amin Cao, Qiang Fang*, Efficient improvement of fluorescence quantum yield of fluoreneethynylene-based polymers by introducing a perfluoroalkylbenzene unit to the polymers, Macromol. Rapid Commun. 2007, 28, 772–779. (IF 4.596)

chao500 · 发表于 2018-3-26 10:47:32

朱为宏领衔的项目“有机功能染料稳定性强化”获得2017年上海自然科学一等奖。

shiziwo · 发表于 2018-7-30 09:27:12

次序响应AND型逻辑门应用于智能药物输送系统

实时监测药物的传递和可控释放是实现肿瘤靶向性精准治疗的关键环节之一。然而，癌症复杂的生理环境和肿瘤异质性使得依托于生物标志物检测进行体内程序化精准诊疗仍存在巨大挑战。近日，华东理工大学精细所朱为宏教授和郭志前教授课题组在近红外荧光前药领域取得了新进展，以“Sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release”为题发表于Chemical Science,2018, 9, 6176-6182。

该工作创新性提出基于布尔逻辑运算的双通道近红外智能药物输送系统，其所构建序列响应的AND型逻辑门可以有效避免前药免非特异性激活，只有通过内源性肿瘤标志物的精准激活才会进行药物释放。特别是双通道近红外荧光信号响应实现了对药物释放过程的实时示踪，能有效减少抗癌药物的副作用和实时监测药物何时、何地、如何发挥其治疗效果，这种序列响应的AND型逻辑门为开发精确可编程的药物输送系统和智能生物传感探针提供了新思路。该文章被Chemical Science评选为“2018 Chemical Science HOT Article Collection”、“2018 ChemSci Pick of the Week Collection”以及Chemical Science内封面文章，并被RSC英国皇家化学会“New & events”版块以《Targeting tumours》为题对该文章进行专题评述。

在复杂生物环境中实现精准的可编程诊断和治疗仍然非常具有挑战，特别是消除来自非特异性激活的“假阳性”信号尤为困难。该工作创新性通过共价键将双通道菁染料（Cy）荧光前药连接于超灵敏pH响应聚合物的疏水嵌段，构建具有序列响应的AND型布尔逻辑门，实现了利用近红外双通道荧光实时示踪药物在活体中次序性响应的“解离-释放”过程。该工作利用序列响应AND型逻辑门的设计策略，通过双通道可视化实时示踪前药过程，有效增加了药物的靶向能力和精准释放，显著提高其对肿瘤的治疗效率。

该工作巧妙设计了序列激活的AND逻辑型双通道近红外纳米前药P(Cy-S-CPT)，实现了对药物释放的实时监测，表现出精确的肿瘤靶向性和优异的生物分布，展现了显著的肿瘤治疗效果，这种具有逻辑判断能力的纳米探针可以作为智能体内生物传感探针的一个概念原型，为精确可编程药物输送系统的开发提供有益的思路。

该工作主要由博士研究生燕宸旭完成，并得到了田禾院士的悉心指导。该研究成果由国家自然科学基金委基础科学中心项目，以及创新研究群体项目和优秀青年基金项目共同资助完成。

原文链接：

http://pubs.rsc.org/en/content/articlelanding/2018/sc/c8sc02079e#!divAbstract

英国国家化学会“New & events”版块以《Targeting tumours》为题的Highlight链接：

http://www.rsc.org/news-events/journals-highlights/2018/jul/targeting-tumours/

英国化学会微信专题报道:https://mp.weixin.qq.com/s/RNaJeQ1C7rt3nMKd4uP23w

cuihuo · 发表于 2019-2-14 15:53:48

华东理工大学朱为宏和郭志前教授课题组等采用理性的“step-by-step”分子设计策略来解决商业染料ThT的固有缺陷，通过引入亲脂性π-共轭噻吩桥扩展到NIR近红外波长范围，并使其满足BBB穿透性所需的亲脂性需求，进一步通过改变亲水性磺酸盐基团的取代位置，保证特定的亲水性使分子在结合Aβ沉积之前处于分散态，以保证AIE探针在未结合Aβ斑块前荧光维持荧光关闭off状态，展示了近红外(NIR)聚集诱导发射(AIE)-Aβ斑块活性探针的合理设计策略。近红外探针QM-FN-SO3已经很好地解决了AIE在较长发射的亲脂性要求和从水到蛋白质原纤维形成的聚集行为之间的问题，从而在体内检测具有显著结合亲和力的Aβ斑块的高保真反馈方面取得了突破，可以作为商业探针ThT或ThS的有效替代品。该研究成果今日以题为“Rational Design of Near-Infrared Aggregation-Induced-EmissionActive Probes: In Situ Mapping of Amyloid‑β Plaques with Ultrasensitivity and High-Fidelity”发表在知名期刊JACS上。

shimian · 发表于 2019-4-9 17:17:29

近日，华东理工大学朱为宏教授课题组和深圳大学余振强副教授课题组合作，利用聚集诱导发光（AIE）喹啉睛染料在不同粘度环境下荧光强度的变化，实现了煎炸油中食品危害物甘油三酯聚合物的实时快速检测，相关成果以“Broadening AIEgen application: rapid and portable sensing of foodstuff hazards in deep-frying oil”为题，发表于国际期刊Chemical Communications。

煎炸科学属于食品研究领域主流学科，西式快餐、方便面、薯片、油条、麻花、兰花豆等均属煎炸食品。煎炸研究主要集中在煎炸油方向，在超过180 ℃的高温下反复煎炸，煎炸油会产生大量酸、醛、酮、酯、以及甘油三酯的二聚、寡聚等食品危害物并在煎炸油中不断积累（图1），这类危害物与消化、心血管疾病息息相关。一般认为甘油三酯聚合物含量达到10-16%时即达到食品安全警戒值，煎炸油应当被废弃。目前煎炸油中聚合物含量检测需将样品送至专业实验室通过液相色谱进行分析，流程繁琐，不利于快餐店等小商家自身的品控管理，存在较大的食品风险，因此迫切需要发展煎炸油甘油三酯聚合物的实时、现场检测方法。

图1 煎炸食品及甘油三酯聚合物产生示意图

作者将新型的AIE喹啉腈荧光团与三苯胺单元连接，得到了AIE活性的荧光探针QM-TPA。三苯胺为大π结构，旋转时对外部粘度环境非常敏感，因而QM-TPA在不同粘度环境下呈现出不同强度荧光。在不同比例甘油（0-90% v/v）-乙醇体系下，粘度由1.2 cP增加至625 cP，与之对应的QM-TPA荧光强度增加了26倍，并且呈较好的直线关系，表明AIE探针QM-TPA能够定量地检测体系粘度的变化。

论文作者吴玥、靳鹏伟博士毕业后曾在国际知名食品公司工作，针对QM-TPA对粘度敏感性质，创新性地将其引入到煎炸油甘油三酯聚合物实时快速检测中。在长时间高温煎炸下，煎炸油发生了大量的氧化与聚合反应，生成甘油三酯二聚或多聚化合物。通过100批薯条反复煎炸，煎炸油内聚合物积聚，液相色谱分析发现甘油三酯聚合物含量由最初的3.5%上升至13.65%，粘度也随之升高。利用QM-TPA进行荧光检测，发现其荧光强度与聚合物含量呈线性关系。基于荧光快速检测甘油三酯聚合物含量，避免需将样品送往专业实验室进行色谱分析的困扰，为煎炸油品质的实时、现场监控提供新的思路。

该工作得到了国家自然科学基金委基础科学中心项目、上海市重大专项、深圳市科创委资助。

文章链接：https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc01172b#!divAbstract

hezuo · 发表于 2020-1-16 22:36:07

朱为宏教授领衔的项目“有机功能染料稳定性强化原理与应用基础研究”荣获国家自然科学奖二等奖。该项目聚焦功能染料稳定性强化及其应用，基于强吸电子受体，系统性地通过分子内电荷分离、轨道能级与芳香离域度调控等策略，创新建立了精细化应用过程中染料的稳定性强化机制及原理：创新引入额外受体提出D-A-π-A新模型，实现了辅助受体强化分子内电荷转移及有效分离，建立了高稳定性敏化染料设计策略；基于强受体烯桥，揭示了芳香离域度和自组装调控光致异构反应能垒的机制，构建了双稳态光致变色染料新体系；基于强受体发展具有自主知识产权的高稳定性喹啉腈染料新母体，显著提升荧光染料稳定性及应用性能，并采用涡流强化实现染料聚集态的宏量、可控制备。项目总体上促进了功能染料在新兴领域高附加值应用。

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