Figure 1. A: Schematic illustration of the formation of Janus hydrogel by gradient polyelectrolyte complexation via dipping one-side of carboxyl-containing self-adhesive hydrogel in polycation solution, as well as its application for underwater adhesion; B: the adhesion property of bottom surface of the Janus hydrogel to stomach; C: the adhesion property of top surface of the Janus hydrogel to stomach. (Scale bar: 1.5 cm)
含羧基的凝胶与寡聚糖直接接触的一面,因羧基几乎全部被复合而失去黏附性,而远离寡聚糖溶液的一面,则因在最外表面保留了自由羧基而具有黏附性,并且由于羧基和氨基的静电复合导致的相分离还赋予了该面疏水和排水的能力,因此,这一侧表面对生物软组织均显示出了优异的湿态黏附效果(图2)。
Figure 2. Underwater instant adhesion of the Janus hydrogel to PAAm hydrogel, pig skin, stomach and intestine; all the adhered substrates can lift a weight of 100 g.
将该“两面神”黏附水凝胶用于动物体内胃穿孔的修复,黏附面可以牢固地黏接在胃穿孔部位,促进了穿孔部位的组织修复,而不粘面则起到了防止组织间黏连的作用,并且该凝胶在体内14天内完全降解。而使用手术缝合线对胃穿孔部位进行修复后,则表现出了明显的组织黏连(图3)。
Figure 3. Janus hydrogel for gastric perforation repair. A rabbit stomach perforation model was created by piercing the stomach with scissors (stomach perforation diameter is about 0.5cm) and rabbit’s gastric perforation was repaired with the Janus hydrogel (A) (the bottom surface of the Janus hydrogel was adhered to the perforation site of the rabbit stomach, and the top surface of the Janus hydrogel was gently pressed for 30 s) and surgical suture (B) with a comparison of the healing effect at day 7, 10 and 14 after surgery (the blue and green circles are the gastric perforation sites of the rabbit’s stomach).
目前上述工作已发表在《Advanced Functional Materials》上,论文第一作者为天津大学材料学院博士生崔春燕,通讯作者为天津大学材料学院刘文广教授。论文连接:https://onlinelibrary.wiley.com/doi/10.1002/adfm.202005689
文章来源:天津大学
刘文广教授于天津大学获学士、硕士和博士学位,毕业后在天津大学材料学院高分子系工作,2005.3-2006.12加拿大渥太华大学医学院博士后研究员,2004.3-2004.11香港理工大学Research Associate,2003.7-2004.1香港大学医学院骨科系访问学者。主要从事水凝胶和纳米药物/基因载体等生物医用高分子材料研究。在Progress in Polymer Science, Advanced Materials, Advanced Functional Materials, Chemical Science,Biomaterials等国际著名材料类期刊发表150余篇论文,申请中国发明专利25项,授权15项。获天津市自然科学一等奖一项,2013年获国家杰出青年科学基金,2014年获得天津大学教书育人标兵称号,2014年获得天津市五一劳动奖章称号,2016年获国务院政府特殊津贴专家称号。