代表性成果:
1. 美国授权专利
Temperature-controlled electrospray ionization source and methods of use thereof, 2014, 专利号: US8766179
2. 译著
王冠博, 马玉国. 《化学演示实验-化学教师手册》, <美> B. Z. Shakhashiri著. 北京大学出版社, 2013 (ISBN: 9787301221464)
3. 代表性期刊论文
Yue Shen, Xiuxiu Zhao, Guanbo Wang*, David D. Y. Chen*, Differential Hydrogen/Deuterium Exchange during Proteoform Separation Enables Characterization of Conformational Differences between Coexisting Protein States, Analytical Chemistry, 2019, doi: 10.1021/acs.analchem.9b00558
Wenjun Tong, Guanbo Wang*, How can native mass spectrometry contribute to characterization of biomacromolecular higher-order structure and interactions? Methods, 2018, 144: 3-13
Xiuxiu Zhao#, Yue Shen#, Wenjun Tong, Guanbo Wang*, David D. Y. Chen*, Deducing Disulfide Patterns of Cysteine-rich Proteins Using Signature Fragments Produced by Top-down Mass Spectrometry, Analyst, 2018, 143(4): 817-823
Guanbo Wang*, Pavel V. Bondarenko, Igor A. Kaltashov, Multi-step Conformational Transitions in Heat-treated Protein Therapeutics can be Monitored in Real Time with Temperature-controlled Electrospray Ionization Mass Spectrometry, Analyst, 2018, 143(3): 670-677
Guanbo Wang, Rinat R. Abzalimov, Cedric E. Bobst, Igor A. Kaltashov*. Conformer-specific characterization of non-native protein states using hydrogen exchange and top-down mass spectrometry. Proceedings of the National Academy of Sciences U.S.A., 2013, 110(50): 20087-20092
Guanbo Wang, Rob N. de Jong, Ewald T. J. van den Bremer, Frank J. Beurskens, Aran F. Labrijn, Deniz Ugurlar, Piet Gros, Janine Schuurman, Paul W. H. I. Parren*, Albert J. R. Heck*. Molecular basis of assembly and activation of complement component C1 in complex with Immunoglobulin G1 and antigen. Molecular Cell, 2016, 63(1): 135-145
Guanbo Wang Rob N. de Jong, Ewald T. J. van den Bremer, Paul W. H. I. Parren, Albert J. R. Heck*. Enhancing accuracy in molecular weight determination of highly heterogeneously glycosylated proteins by native tandem mass spectrometry. Analytical Chemistry, 2017, 89(9): 4793-4797
Guanbo Wang and Igor A. Kaltashov*. Approach to characterization of the higher order structure of disulfide-containing proteins using hydrogen/deuterium exchange and top-down mass spectrometry. Analytical Chemistry, 2014, 86(15): 7293-7298
Guanbo Wang, Alex J. Johnson, Igor A. Kaltashov*. Evaluation of Electrospray Ionization Mass Spectrometry as a Tool for Characterization of Small Soluble Protein Aggregates. Analytical Chemistry, 2012, 84(3): 1718-1724
Guanbo Wang, Rinat R. Abzalimov, Igor A. Kaltashov*. Direct Monitoring of Heat-Stressed Biopolymers with Temperature-Controlled Electrospray Ionization Mass Spectrometry. Analytical Chemistry, 2011, 83(8): 2870-2876 (accelerated article)
Yang Yang#, Guanbo Wang#, Ting Song, Carlito Lebrilla, Albert J. R. Heck*. Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches. mAbs, 2017, 9(4): 638-645