主要研究方向:
1) 纳米材料的合成、修饰和功能化
2) 免疫层析试纸条、微纳电子器件及生物/化学传感器的开发
3) 多功能纳米材料在多模态生物成像和肿瘤治疗中的应用
4) 细胞内和细胞表面蛋白质糖基化分析及其与肿瘤的关系研究
主持科研项目:
1) 国家自然科学基金(面上基金),项目号:21475106,经费:85万元
2) 国家自然科学基金(青年基金),项目号:31200604,经费:23万元
3) 重庆市自然科学基金,项目号:cstc2012jjA10152,经费:5万元
4) 中央高校基本科研业务费(重点项目),项目号:XDJK2015B015,经费:10万元
5) 中央高校基本科研业务费(一般项目),项目号:XDJK2012C083,经费:4万元
6) 西南大学人才引进基金,项目号:SWU111071,经费:30万元
代表论文:
目前共发表 SCI 期刊论文 40余篇; H 指数(H index):18
1. Z. Y. Zhang, J. Xie, J. Yu, Z. S. Lu, Y. S. Liu*: A novel colorimetric immunoassay strategy using iron(III) oxide magnetic nanoparticles as a label for signal generation and amplification. J. Mater. Chem. B, 2017, 5(7), 1454-1460.
2. Y. S. Liu*, Z. Y. Zhang, J. Yu, J. Xie: Concentration-dependent multicolor conversion strategy for ultrasensitive colorimetric immunoassay with naked eyes. Anal. Chim. Acta, 2017, 963, 129-135.
3. Y. S. Liu*, J. Yu: Oriented immobilization of proteins on solid supports for use in biosensors and biochips: a review. Microchim. Acta, 2016, 183(1), 1-19. (Invited review)
4. Y. S. Liu, W. H. Hu, Z. S. Lu, C. M. Li: ZnO Nanomulberry and Its Significant Non-enzymatic Signal-Enhancement for Protein Microarray. ACS Appl. Mater. Inter., 2014, 6, 7728-7734.
5. W. H. Hu, Y. S. Liu, T. Chen, Y. Liu, C. M. Li: Hybrid ZnO Nanorod-Polymer Brush Hierarchically Nanostructured Substrate for Sensitive Antibody Microarrays. Adv. Mater., 2015, 27(1), 181-185.
6. Y. S. Liu*, Y. Y. Zhang, Z. S. Lu, C. M. Li*: 3-D microarray and its microfabrication-free fluidic immunoassay device. Anal. Chim. Acta, 2015, 889, 187-193.
7. Y. S. Liu*, J. Yu, Y. Wang, Z. Y. Liu, Z. S. Lu: An ultrasensitive aptasensor for detection of Ochratoxin A based on shielding effect-induced inhibition of fluorescence resonance energy transfer. Sens. Actuat. B-Chem., 2016, 222, 797-803.
8. Y. S. Liu*, Y. Y. Zhang, Y. N. Zhao, J. Yu: Phenylboronic acid polymer brush-enabled oriented and high density antibody immobilization for sensitive microarray immunoassay. Colloids Surf. B: Biointerfaces, 2014, 121, 21-26.
9. Y. S. Liu*, Y. N. Zhao, Y. Y. Zhang: One-step green synthesized fluorescent carbon nanodots from bamboo leaves for copper (Ⅱ) ion detection. Sens. Actuat. B-Chem, 2014, 196, 647–652.
10. W. H. Hu#, Y. S. Liu#, H. B. Yang, X. Q. Zhou, and C. M. Li: ZnO Nanorods-Enhanced Fluorescence for Sensitive Microarray Detection of Cancers in Serum without Additional Reporter-Amplification. Biosens. Bioelectron., 2011, 26(8), 3683-3687. (Equal first author)
授权和申请专利:
1. 刘英帅,鲁志松,杨旭: DNA-蛋白质交联定量检测试剂盒。专利号:ZL2004 2 0111383.1
2. 刘英帅,张泽英: 纳米金催化铜沉积介导的浓度依赖多色转变比色分析方法和应用。申请号:201510527219.1
3.李长明,刘英帅,张嫄媛:高通量三维微流控芯片免疫测定装置及其制备方法。专利号:ZL201410260221.2
4. 李长明,胡卫华,刘英帅:纳米氧化锌修饰的免疫毛细管及其制备方法和应用。专利号:ZL201210550889.1
5.李长明,胡卫华,刘英帅:基于枝状聚合物的微阵列抗体芯片的制备方法及其产品。专利号:ZL201410310087.2