东华大学化学化工与生物工程学院沈明武

maichun

沈明武，1971年8月生，化学化工与生物工程学院生物工程系研究员。2001年毕业于清华大学，获工学博士。2008年回国前，在美国密歇根大学历任访问学者和副研究员。多年来主要从事纳米医学与生物材料技术等领域的应用基础研究，内容主要涉及了杂化纳米材料的肿瘤单模态CT、MR成像，或双模态CT/MR、SPECT/CT和SPECT/MR成像、以及作为化疗药物、基因和光热转换剂的载体用于肿瘤化疗、基因、光热以及联合治疗。共发表SCI学术期刊论文150多篇和5篇书的章节，获授权专利20余项。论文主要发表在Chem. Soc. Rev.、Small、Biomaterials、ACS Appl. Mater. Interfaces、Nanoscale、J. Mater. Chem. B等国际主流专业期刊上。

研究方向：

1、  基于超支化大分子的纳米医学：

a. 有机/无机纳米复合材料的合成及其在肿瘤分子影像诊断中的应用；

b. 纳米药物输送体系的制备与抗肿瘤效果评价；

c. 有机/无机杂化纳米颗粒用于基因传递的研究；

2、静电纺纳米纤维材料在生物医学与环境科学中的应用。

荣誉及获奖情况：

1、  2000年：中国高校科学技术奖一等奖。

2、  2001年：国家自然科学奖二等奖。

3、  2010年：高校科学研究优秀成果奖自然科学奖一等奖。

4、  2016年：中国医疗保健国际交流促进会华夏医学科技奖二等奖。

5、  2017年：中华医学科技奖三等奖。

6、  2017年：上海市科技进步奖一等奖。

近年来承担的主要科研项目：

1、  多功能磁性氧化铁/金核壳纳米颗粒的构建及其CT/MRI双重模式肿瘤成像诊断研究, 国家自然科学基金青年基金（81101150），2012.1-2014.12，项目主持人。

2、  基于树状大分子的多功能复合纳米颗粒分子影像探针的构建及其双模态肿瘤靶向成像诊断（12520705500），上海市科委国际合作项目，2012.10-2014.9，项目主持人。

3、  基于超支化聚乙烯亚胺的多功能纳米平台的构建及其肿瘤诊断与治疗应用（81341050），国家自然科学基金主任基金，2014.1-2014.12，项目主持人。

4、  利用超支化聚合物构建纳米凝胶平台及其肿瘤CT/MRI双模态成像诊断研究，中央高校，2015.1-2017.12

5、  利用支化聚乙烯亚胺构建多功能双模态SPECT/CT 纳米探针及其肿瘤影像诊断应用, 上海市科委政府间国际合作项目(15520711400)，2015.10-2018.9，项目主持人。

近年来发表的代表性论著、专利：

论文（近五年）

1.   Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, Xiangyang Shi *,Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy, Chem. Soc. Rev., 2018, 47, 1874-1900

2.   Benqing Zhou, Ruizhi Wang, Lingzhou Zhao, Peng Wang, Xin Li, István Bányai*, Qiang Ouyang*, Xiangyang Shi, Mingwu Shen*, RGD Peptide-Targeted Polyethylenimine-Entrapped Gold Nanoparticles Radiolabeled with 99mTc for Targeted SPECT/CT Imaging of an Orthotopic Model of Human Hepatic Carcinoma, ACS Appl. Mater. Interfaces, 2018, 10(7), 6146-6154

3.   Xin Li#, Lingxi Xing#, Kailiang Zheng, Ping Wei, Lingzhou Zhao, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. Formation of Gold Nanostar-Coated Hollow Mesoporous Silica for Tumor Multi-Modality Imaging and Photothermal Therapy. ACS Appl. Mater. Interfaces 2017, 9, 5817−5827.

4.   Jingchao Li, Shige Wang, Xiangyang Shi,* Mingwu Shen*. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci. 2017, 249, 374–385.

5.   Benqing Zhou, Zuogang Xiong, Peng Wang, Chen Peng*, Mingwu Shen*, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*.Targeted tumor dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold nanoparticles loaded with gadolinium. Drug Delivery 2018, 25, 178-186

6.   Xin Li, Lingxi Xing, Yong Hu, Zhijuan Xiong, Ruizhi Wang, Xiaoying Xu, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. An RGD-modified hollow silica@Au core/shell nanoplatform for tumor combinational therapy. Acta Biomater. 2017, 62, 2017, 273-283.

7.   Du Li, Jia Yang, Shihui Wen, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles. J. Mater. Chem. B 2017, 5, 2395- 2401.

8.   Feng Chen, Lingdan Kong, Le Wang, Yu Fan, Mingwu Shen*, Xiangyang Shi*. Construction of Core-shell Tecto Dendrimers Based on Supramolecular Host-Guest Assembly for Enhanced Gene Delivery. J. Mater. Chem. B 2017, 5, 8459--8466.

9.   Xiaoying Xu, Lingzhou Zhao, Xin Li, Peng Wang, Jinhua Zhao,* Xiangyang Shi*, Mingwu Shen*. Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles. Biomater. Sci. 2017, 5, 2393–2397.

10.  Yong Hu#, Ruizhi Wang#, Jingchao Li, Ling Ding, Xiaolin Wang,* Xiangyang Shi,* Mingwu Shen*. Facile Synthesis of Lactobionic Acid-Targeted Iron Oxide Nanoparticles with Ultrahigh Relaxivity for Targeted MR Imaging of an Orthotopic Model of Human Hepatocellular Carcinoma. Part. Part. Syst. Charact. 2017, 34, 1600113.

11.  Xin Li, Zuogang Xiong, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and Xiangyang Shi*. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors. ACS Appl. Mater. Interfaces 2016, 8, 19883-19891.

12.  Ping Wei, Jingwen Chen, Yong Hu, Xin Li, Han Wang*, Mingwu Shen*, Xiangyang Shi*. Dendrimer-Stabilized Gold Nanostars as a Multifunctional Theranostic Nanoplatform for CT Imaging, Photothermal Therapy, and Gene Silencing of Tumors. Adv. Healthcare Mater. 2016, 5 (24), 3203-3213.

13.  Wenjie Sun, Serge Mignani, Mingwu Shen*, Xiangyang Shi*. Dendrimer-based magnetic iron oxide nanoparticles: synthesis and biomedical applications. Drug Discovery Today 2016, 21 (12), 1873-1885.

14.  Yu Luo, Lingzhou Zhao, Xin Li, Jia Yang, Lilei Guo, Guixiang Zhang, Mingwu Shen*, Jinhua Zhao*, Xiangyang Shi*. The design of a multifunctional dendrimer-based nanoplatform for targeted dual mode SPECT/MR imaging of tumors. J. Mater. Chem. B 2016, 4, 7220-7225

15.  Wenjie Sun, Jia Yang, Jianzhi Zhu, Yiwei Zhou, Jingchao Li, Xiaoyue Zhu, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Immobilization of Iron Oxide Nanoparticles within Alginate Nanogels for Enhanced MR Imaging Applications. Biomater. Sci. 2016, 4, 1422-1430

16.  Benqing Zhou, Mingwu Shen*, István Bányai,* Xiangyang Shi*. Structural characterization of PEGylated polyethylenimine-entrapped gold nanoparticles: An NMR study. Analyst 2016, 141, 5390 - 5397.

17.  Hongdong Cai, Kangan Li, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen,* Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors. Small 2015, 11 (35), 4584-4593.

18.  Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials 2015, 38, 10-21.

19.  Jingchao Li, Yong Hu, Jia Yang, Wenjie Sun, Hongdong Cai, Ping Wei, Yaping Sun,* Guixiang Zhang, Xiangyang Shi*, Mingwu Shen*. Facile synthesis of folic acid-functionalized iron oxide nanoparticles with ultrahigh relaxivity for targeted tumor MR imaging. J. Mater. Chem. B 2015, 3, 5720 - 5730.

20.  Qian Chen, Han Wang, Hui Liu, Shihui Wen, Chen Peng, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Multifunctional Dendrimer-Entrapped Gold Nanoparticles Modified with RGD Peptide for Targeted Computed Tomography/Magnetic Resonance Dual-Modal Imaging of Tumors. Anal. Chem. 2015, 87 (7), pp 3949–3956.

21.  Yong Hu, Jia Yang, Ping Wei, Jingchao Li, Ling Ding, Guixiang Zhang,* Xiangyang Shi,* Mingwu Shen*. Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors. J. Mater. Chem. B 2015, 3, 9098-9108.

22.  Hongdong Cai, Xiao An, Shihui Wen, Jingchao Li, Guixiang Zhang*, Xiangyang Shi*, Mingwu Shen*. Facile One-Pot Synthesis of Gd(OH)3-Doped Fe3O4 Nanoparticles for Dual-Mode T1- and T2-Weighted Magnetic Resonance Imaging Applications. Part. Part. Syst. Charact. 2015, 32, 934–943.

23.  Yu Luo, Jia Yang, Yu Yan, Jingchao Li, Mingwu Shen,* Guixiang Zhang,* Serge Mignani, Xiangyang Shi*. RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of glioma. Nanoscale 2015, 7, 14538–14546.

24.  Yong Hu, Jingchao Li, Jia Yang, Ping Wei, Yu Luo, Ling Ding, Wenjie Sun, Guixiang Zhang*, Xiangyang Shi*, Mingwu Shen*. Facile synthesis of RGD peptide-modified iron oxide nanoparticles with ultrahigh relaxivity for targeted MR imaging of tumors. Biomater. Sci. 2015, 3, 721-732

25.  Jingchao Li, Yao He, Wenjie Sun, Hongdong Cai, Yunqi Pan, Mingwu Shen**, Jindong Xia***, Xiangyang Shi*. Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging. Biomaterials 2014, 35, 3666-3677.

26.  Hui Liu+, Han Wang+, Yanhong Xu+, Rui Guo, Shihui Wen, Yunpeng Huang, Weina Liu, Mingwu Shen*, Jinglong Zhao, Guixiang Zhang*, and Xiangyang Shi*. Lactobionic Acid-Modified Dendrimer-Entrapped Gold Nanoparticles for Targeted CT Imaging of Human Hepatocellular Carcinoma. ACS Appl. Mater. Interfaces 2014, 6, 6944−6953.

27.  Benqing Zhou, Linfeng Zheng, Chen Peng, Du Li, Jingchao Li, Shihui Wen, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Synthesis and characterization of PEGylated polyethyleneimine-entrapped gold nanoparticles for blood pool and tumor CT imaging. ACS Appl. Mater. Interfaces 2014, 6, 17190−17199.

28.  Jingchao Li, Xiangyang Shi,* Mingwu Shen*. Hydrothermal Synthesis and Functionalization of Iron Oxide Nanoparticles for MR Imaging Applications. Part. Part. Syst. Charact. 2014, 31, 1223–1237.

29.  Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* and Xiangyang Shi*. Polyethyleneimine-Mediated Synthesis of Folic Acid-Targeted Iron Oxide Nanoparticles for in Vivo Tumor MR Imaging. Biomaterials 2013, 34, 8382-8392.

30.  Fuyin Zheng, Shige Wang, Shihui Wen, Mingwu Shen,** Meifang Zhu, Xiangyang Shi*. Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Biomaterials 2013, 34, 1402-1412.

31.  Hongdong Cai, Xiao An, Jun Cui, Jingchao Li, Shihui Wen, Kangan Li, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang*, Xiangyang Shi*. Facile Hydrothermal Synthesis and Surface Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical Applications. ACS Appl. Mater. Interfaces 2013, 5 (5), 1722–1731.

32.  Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Facile One-Pot Synthesis of Fe3O4@Au Composite Nanoparticles for Dual Mode MR/CT Imaging Applications. ACS Appl. Mater. Interfaces 2013, 5(20), 10357-10366.

33.  Fuyin Zheng, Shige Wang, Mingwu Shen,* Meifang Zhu, Xiangyang Shi*. Antitumor efficacy of doxorubicin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Polym. Chem., 2013, 4(4), 933-941.

34.  Yu Luo, Shige Wang, Mingwu Shen,* Ruiling Qi, Yi Fang, Rui Guo, Hongdong Cai, Xueyan Cao, Helena Tomás, Meifang Zhu, and Xiangyang Shi*. Carbon nanotube-incorporated multilayered cellulose acetate nanofibers for tissue engineering applications. Carbohydr. Polym. 2013, 91, 419- 427.

专利

1.   沈明武，罗宇，史向阳. 具有良好生物相容性CA/CS/CNTs复合纳米纤维的制备方法,　中国发明专利，专利号：ZL 201010538059.8，授权日期：2013/5/15。

2.   沈明武，蔡红东，史向阳。一种APTS修饰的氧化铁磁性纳米颗粒的制备方法。中国发明专利，专利号：ZL 201110104443.1，授权日期：2013/5/8。

3.   沈明武，黄云鹏，胡登脉，史向阳。特异性吸附汞离子PVA/PEI-T纳米纤维膜的制备方法。中国发明专利，专利号: ZL201310013489.1，授权日期：2014/8/13。

4.   沈明武，郑赟，张蒙恩，史向阳。一种聚酰胺-胺树状大分子负载α-Tos的制备方法。中国发明专利，专利号: ZL201310057666.6，授权日期：2014/10/15。

5.   沈明武，李静超，蔡红东，史向阳，张贵祥，郑林丰。一种Fe3O4/Au复合纳米颗粒的制备方法。中国发明专利，专利号: ZL201310072165.5，授权日期：2014/10/15。

6.   沈明武，李静超，蔡红东，史向阳，张贵祥,郑林丰. 基于叶酸修饰的四氧化三铁纳米颗粒的靶向MRI造影剂的制备方法. 中国发明专利，专利号: ZL201310105397.6，授权日期：2014/11/05。

7.   沈明武，李静超，胡勇，孙文杰，史向阳。一种叶酸修饰的超顺磁氧化铁纳米颗粒的制备方法。中国发明专利，专利号: ZL201410182821.1，授权日期：2016/8/24。

8.   沈明武，李静超，胡勇，韦平，史向阳。一种金包覆氧化铁星形核壳结构纳米颗粒的制备及其成像和热疗的应用。中国发明专利，专利号: ZL201410333885.7，授权日期：2016/11/9。

9.   沈明武，胡勇，李静超，韦平，史向阳。一种RGD修饰的超小型超顺磁氧化铁纳米颗粒的制备方法。中国发明专利，专利号：ZL201410604468.1，授权日期：2017/4/12。

10.  沈明武，胡勇，李静超，韦平，史向阳。一种RGD修饰的超小型超顺磁氧化铁纳米颗粒的制备方法。中国发明专利，专利号：ZL201410604468.1，授权日期：2017/4/12。

国际交流与合作：

美国密歇根大学（University of Michigan, Ann Arbor），葡萄牙马德拉大学 (Universidade da Madeira)，匈牙利徳布勒森大学（University of Debrecen），德国亚琛工业大学（RWTH Aachen）。

联系电话: 021-67792750              E-MAIL: mwshen@dhu.edu.cn

yunduan

东华大学沈明武教授、史向阳教授和同济大学彭琛博士合作制备了一种在激光照射下合成可形成纳米团簇(NCs)的超小Fe3O4纳米颗粒，并将其用于动态增强的T1/ T2加权磁共振成像（MRI）。实验通过溶剂热法合成了柠檬酸稳定的超小Fe3O4 NPs，并将其与靶向关节炎的配体叶酸(FA)和光控单元双吖丙啶(DA)相连接形成了超小的Fe3O4-PEG-(DA)-FA NPs，它具有良好的生物相容性和FA介导的对关节炎相关巨噬细胞的特异靶向性。该NPs在被激光照射后可形成NCs，并且通过改变激光的照射时间可调节其r1和r2的相关系数。因此，Fe3O4-PEG(DA)-FA NPs可在没有激光的条件下对关节炎进行T1加权成像；而在有激光的条件下可进行增强的双模T1 / T2加权成像，而这与其在光照下形成的NCs有关。

XinLi, Chen Peng, Mingwu Shen, Xiangyang Shi. et al. Light-AddressableNanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and DynamicMagnetic Resonance Imaging of Arthritis. Advanced Science. 2019DOI:10.1002/advs.201901800https://onlinelibrary.wiley.com/doi/10.1002/advs.201901800