联系方式
Emai: zhlin@cqut.edu.cn; Tel: 023-62563460
研究方向
计算机辅助疫苗设计与免疫信息学
多肽类药物分子设计与结构修饰
基于重要靶点的药物设计
代表性论文、专著和专利
[1]Xingyan Luo, Mao Shu, Yuanqiang Wang, Jin Liu, Wenjuan Yang and Zhihua Lin*.3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking. Molecules, 2012, 17, 2015-2029
[2]Yuanqiang Wang, Yuan Ding, Haixia Wen, Yong Lin,Yong Hu, Ya Zhang, Qingyou Xia and Zhihua Lin*.QSAR Modeling and Design of Cationic Antimicrobial Peptides Based on Structural Properties of Amino Acids. Combinatorial Chemistry & High Throughput Screening, 2012, 15, 347-353.
[3]Yuanqing Wang, Xiaoming Cheng, Yong Lin, Haixia Wen, Li Wang, Qingyou Xia, Zhihua Lin*. Quantitative Prediction of TAP and MHC Class I Binding Peptides using QSAR Modeling based on Amino Acid Structural Information. Current Computer-Aided Drug Design, 2012, 8, 50-54.
[4]Mao Shu, Xiaoming Cheng, Yunru Zhang,Yuanqiang Wang, Yong Lin, Li Wang, Zhihua Lin*.Predicting the activity of ACE inhibitory peptides with a novel mode of pseudo amino acid composition.Protein & Peptide Letters,2011,18(12):1233-1243.
[5]Juan Wang, Xiao-Yu Wang, Mao Shu, Yuan-Qiang Wang, Yong Lin, Li Wang,Xiao-Ming Cheng, Zhi-Hua Lin*.QSAR Study on MHC Class I A alleles based on the novel parameters of amino acids.Protein & Peptide Letters,2011,18:956-963.
[6]Jiankun Liu,Yuzhong Duan, Xiaoming Cheng, Xi Chen, Wei Xie, Haixia Long, Zhihua Lin*, Bo Zhu. IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma. Biochemical and Biophysical Research Communications. 2011,407(2):348-354.
[7]Wang Yuanqiang, Zhang Heng, Lin Yong, Zhao Qi, Liu Hui, Zhang zhan, Lin Zhihua*. 3D-QSAR Studies on Caspase-mediated Apoptosis Activity of Phenolic analogues,Journal of Molecular Modelling, 2011,17:1-8.
[8]Xiaoyu Wang, Juan Wang, Yong Lin , Yuan Ding ,Yuanqiang Wang, Xiaoming Cheng, Zhihua Lin*. QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors. Journal of Molecular Modelling, 2011,17:1599-1606.
[9]Xie Rong-Kai, Long Hai-Xia, Cheng Xiao-Ming, Wang Yuan-Qiang, Lin Yong, Yang Ying, Zhu Bo, Lin Zhi-Hua*. Quantitative sequence-kinetics relationship in antigen-antiboby interaction kinetics based on a set of descriptors. Chemical Biology & Drug Design, 2010,76:345-349.
[10] Zhi-hua Lin*, Hai-xia Long, Zhu Bo, Yuan-qiang Wang, Yu-zhang Wu. New descriptors of amino acids and their application to peptide QSAR study.Peptides,2008,29:1798-1805.